The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Duodenum


Psychiatry related information on Duodenum


High impact information on Duodenum

  • The adherent mucus gel acts as a physical barrier against luminal pepsin and provides a stable unstirred layer that supports surface neutralization of acid by mucosal HCO3-. Surface neutralization by mucosal HCO3- provides a major mechanism of protection against acid in the proximal duodenum [9].
  • METHODS: In a double-blind study, we randomly assigned 935 patients who required continuous NSAID therapy and who had ulcers or more than 10 erosions in the stomach or duodenum (or both) to receive 20 mg or 40 mg of omeprazole orally in the morning or 200 microg of misoprostol orally four times daily [10].
  • Expression of p45 NF-E2 messenger RNA was detected in erythroid tissues of normal mice and in the duodenum of normal and severely anaemic beta-thalassaemic (Hbbd-th3/Hbbd-th3) mice [11].
  • The motilin receptor is expressed in enteric neurons of the human duodenum and colon [12].
  • It is hypothesized that the rapid arrival and glucose in the duodenum may produce hunger [13].

Chemical compound and disease context of Duodenum


Biological context of Duodenum

  • BACKGROUND & AIMS: Pdx1 plays a pivotal role in pancreas organogenesis and specification of some types of cells in the duodenum and antral stomach [19].
  • The strong predominance of DRA over NHE3 and NHE2 expression in duodenum was paralleled by much higher Cl-/HCO3- than Na+/H+ exchange rates in brush border membrane vesicles and likely explains the high duodenal HCO3- secretory rates [20].
  • Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose [21].
  • The amino acid sequence deduced from the shorter transcript is identical to a precursor form of secretin recently isolated from porcine duodenum [Gafvelin, G., Jornvall, H. & Mutt, V. (1990) Proc. Natl. Acad. Sci. USA 87, 6781-6785] [22].
  • Dietary iron starvation results in a dramatic upregulation of the Nramp2 isoform I in the proximal portion of the duodenum only, whereas expression in the rest of the small intestine and in kidney remains largely unchanged in response to the lack of dietary iron [23].

Anatomical context of Duodenum


Associations of Duodenum with chemical compounds


Gene context of Duodenum


Analytical, diagnostic and therapeutic context of Duodenum


  1. Histochemical patterns in early lesions and infiltrating adenocarcinomas induced in mouse duodenum by n-ethyl-n'-nitro-n-nitrosoguanidine. Matsuyama, M., Ito, M., Yamada, S., Nakamura, T., Nagayo, T. J. Natl. Cancer Inst. (1976) [Pubmed]
  2. Effect of flurbiprofen and 16,16-dimethyl-prostaglandin E2 on gastrointestinal tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. I. Squamous epithelium and mesenchymal tissue. Lehnert, T., Deschner, E.E., Karmali, R.A., DeCosse, J.J. J. Natl. Cancer Inst. (1987) [Pubmed]
  3. Physiological role for cholecystokinin in reducing postprandial hyperglycemia in humans. Liddle, R.A., Rushakoff, R.J., Morita, E.T., Beccaria, L., Carter, J.D., Goldfine, I.D. J. Clin. Invest. (1988) [Pubmed]
  4. Effect of graded amounts of acid instilled into the duodenum on pancreatic bicarbonate secretion and plasma secretin in duodenal ulcer patients and normal subjects. Isenberg, J.I., Cano, R., Bloom, S.R. Gastroenterology (1977) [Pubmed]
  5. Selective intra-arterial methylene blue injection: a novel method of localizing gastrinoma. Ko, T.C., Flisak, M., Prinz, R.A. Gastroenterology (1992) [Pubmed]
  6. Interdigestive gastroduodenal motility and serum motilin levels in patients with idiopathic delay in gastric emptying. Labò, G., Bortolotti, M., Vezzadini, P., Bonora, G., Bersani, G. Gastroenterology (1986) [Pubmed]
  7. Brain and peripheral opioid peptides after changes in ingestive behavior. Majeed, N.H., Lasoń, W., Przewłocka, B., Przewłocki, R. Neuroendocrinology (1986) [Pubmed]
  8. Effect of vagotomy on ornithine decarboxylase activity in rat duodenal mucosa. Tanaka, J., Fujimoto, K., Sakata, T., Fujimoto, T., Tsunada, S., Iwakiri, R., Yamaguchi, M., Okabe, Y., Yoshimatsu, H. Am. J. Physiol. (1993) [Pubmed]
  9. Gastroduodenal mucosal protection. Allen, A., Flemström, G., Garner, A., Kivilaakso, E. Physiol. Rev. (1993) [Pubmed]
  10. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. Hawkey, C.J., Karrasch, J.A., Szczepañski, L., Walker, D.G., Barkun, A., Swannell, A.J., Yeomans, N.D. N. Engl. J. Med. (1998) [Pubmed]
  11. Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Peters, L.L., Andrews, N.C., Eicher, E.M., Davidson, M.B., Orkin, S.H., Lux, S.E. Nature (1993) [Pubmed]
  12. Receptor for motilin identified in the human gastrointestinal system. Feighner, S.D., Tan, C.P., McKee, K.K., Palyha, O.C., Hreniuk, D.L., Pong, S.S., Austin, C.P., Figueroa, D., MacNeil, D., Cascieri, M.A., Nargund, R., Bakshi, R., Abramovitz, M., Stocco, R., Kargman, S., O'Neill, G., Van Der Ploeg, L.H., Evans, J., Patchett, A.A., Smith, R.G., Howard, A.D. Science (1999) [Pubmed]
  13. Sugar infusion can enhance feeding. Geiselman, P.J., Novin, D. Science (1982) [Pubmed]
  14. Production of adenocarcinomas of the small intestines of Wistar rats fed panfuran-S containing 3-di(hydroxymethyl)amino-6-(5-nitro-2-furylethenyl)-1,2,4-triazine. Konishi, Y., Denda, A., Takahashi, S., Inui, S., Aoki, Y. J. Natl. Cancer Inst. (1978) [Pubmed]
  15. Can the singularity of chronic peptic ulcers be described by catastrophe theory and explained by biofeedback? Kirk, R.M. Gastroenterology (1977) [Pubmed]
  16. Effect of sodium oleate on plasma secretin concentration and pancreatic secretion in dog. Faichney, A., Chey, W.Y., Kim, Y.C., Lee, K.Y., Kim, M.S., Chang, T.M. Gastroenterology (1981) [Pubmed]
  17. Canine intestinal transit and digestion of radiolabeled liver particles. Williams, N.S., Meyer, J.H., Jehn, D., Miller, J., Fink, A.S. Gastroenterology (1984) [Pubmed]
  18. "Melanosis" of the duodenum associated with a gastric ulcer and folic acid deficiency. Sharp, J.R., Insalaco, S.J., Johnson, L.F. Gastroenterology (1980) [Pubmed]
  19. Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice. Fukuda, A., Kawaguchi, Y., Furuyama, K., Kodama, S., Kuhara, T., Horiguchi, M., Koizumi, M., Fujimoto, K., Doi, R., Wright, C.V., Chiba, T. Gastroenterology (2006) [Pubmed]
  20. Down-regulated in adenoma mediates apical Cl-/HCO3- exchange in rabbit, rat, and human duodenum. Jacob, P., Rossmann, H., Lamprecht, G., Kretz, A., Neff, C., Lin-Wu, E., Gregor, M., Groneberg, D.A., Kere, J., Seidler, U. Gastroenterology (2002) [Pubmed]
  21. Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose. da Silva Xavier, G., Rutter, J., Rutter, G.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  22. The secretin gene: evolutionary history, alternative splicing, and developmental regulation. Kopin, A.S., Wheeler, M.B., Nishitani, J., McBride, E.W., Chang, T.M., Chey, W.Y., Leiter, A.B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  23. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Canonne-Hergaux, F., Gruenheid, S., Ponka, P., Gros, P. Blood (1999) [Pubmed]
  24. Experimental induction of pancreatic adenocarcinoma in rats. Dissin, J., Mills, L.R., Mains, D.L., Black, O., Webster, P.D. J. Natl. Cancer Inst. (1975) [Pubmed]
  25. Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5'-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes. Matern, S., Matern, H., Farthmann, E.H., Gerok, W. J. Clin. Invest. (1984) [Pubmed]
  26. Peptone stimulates CCK-releasing peptide secretion by activating intestinal submucosal cholinergic neurons. Li, Y., Owyang, C. J. Clin. Invest. (1996) [Pubmed]
  27. Changes in the structure and regeneration mode of the rat small intestinal mucosa following benzalkonium chloride treatment. Holle, G.E. Gastroenterology (1991) [Pubmed]
  28. Comparison of salsalate and aspirin on mucosal injury and gastroduodenal mucosal prostaglandins. Cryer, B., Goldschmiedt, M., Redfern, J.S., Feldman, M. Gastroenterology (1990) [Pubmed]
  29. Inhibitory effects of tetragastrin and histamine on carcinogenesis in the small intestines of W rats by N-methyl-N'-nitro-N-nitrosoguanidine. Tatsuta, M., Iishi, H., Ichii, M., Noguchi, S., Yamamura, H., Taniguchi, H. J. Natl. Cancer Inst. (1986) [Pubmed]
  30. First-pass gastric mucosal metabolism of ethanol is negligible in the rat. Smith, T., DeMaster, E.G., Furne, J.K., Springfield, J., Levitt, M.D. J. Clin. Invest. (1992) [Pubmed]
  31. Regulation of the fasting enterohepatic circulation of bile acids by the migrating myoelectric complex in dogs. Scott, R.B., Strasberg, S.M., El-Sharkawy, T.Y., Diamant, N.E. J. Clin. Invest. (1983) [Pubmed]
  32. Ulcer formation and associated tumor production in multiple sites within the stomach and duodenum of rats treated with N-methyl-N'-nitro-N-nitrosoguanidine. Takahashi, M., Shirai, T., Fukushima, S., Ito, N., Kokubo, T., Furukawa, F., Kurata, Y. J. Natl. Cancer Inst. (1981) [Pubmed]
  33. Effects of a cholecystokinin receptor antagonist on intestinal phase of pancreatic and biliary responses in man. Hildebrand, P., Beglinger, C., Gyr, K., Jansen, J.B., Rovati, L.C., Zuercher, M., Lamers, C.B., Setnikar, I., Stalder, G.A. J. Clin. Invest. (1990) [Pubmed]
  34. MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse. De Lisle, R.C., Petitt, M., Huff, J., Isom, K.S., Agbas, A. Gastroenterology (1997) [Pubmed]
  35. Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract. McDonnell, W.M., Scheiman, J.M., Traber, P.G. Gastroenterology (1992) [Pubmed]
  36. Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum. Pietrangelo, A., Rocchi, E., Casalgrandi, G., Rigo, G., Ferrari, A., Perini, M., Ventura, E., Cairo, G. Gastroenterology (1992) [Pubmed]
  37. Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus. Kaur, B.S., Khamnehei, N., Iravani, M., Namburu, S.S., Lin, O., Triadafilopoulos, G. Gastroenterology (2002) [Pubmed]
  38. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. Tomasetto, C., Masson, R., Linares, J.L., Wendling, C., Lefebvre, O., Chenard, M.P., Rio, M.C. Gastroenterology (2000) [Pubmed]
  39. Ricinoleic acid effect on the electrical activity of the small intestine in rabbits. Mathias, J.R., Martin, J.L., Burns, T.W., Carlson, G.M., Shields, R.P. J. Clin. Invest. (1978) [Pubmed]
  40. Rapid clearance of a structural isomer of bilirubin during phototherapy. Ennever, J.F., Costarino, A.T., Polin, R.A., Speck, W.T. J. Clin. Invest. (1987) [Pubmed]
  41. Duodenal ulcerogens cysteamine and propionitrile induce gastroduodenal motility alterations in the rat. Pihan, G., Kline, T.J., Hollenberg, N.K., Szabo, S. Gastroenterology (1985) [Pubmed]
  42. Effect of aging on gastric and duodenal mucosal prostaglandin concentrations in humans. Cryer, B., Redfern, J.S., Goldschmiedt, M., Lee, E., Feldman, M. Gastroenterology (1992) [Pubmed]
  43. A new model of duodenal ulcers induced in rats by indomethacin plus histamine. Takeuchi, K., Furukawa, O., Tanaka, H., Okabe, S. Gastroenterology (1986) [Pubmed]
WikiGenes - Universities