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MeSH Review

Mice, Knockout

 
 
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Disease relevance of Mice, Knockout

 

Psychiatry related information on Mice, Knockout

 

High impact information on Mice, Knockout

  • However, studies conducted with knockout mice, neutralizing antibodies, and novel antagonists demonstrate that IL-13 possesses several unique effector functions that distinguish it from IL-4 [11].
  • Since the description of the first mouse knockout for an IgG Fc receptor seven years ago, considerable progress has been made in defining the in vivo functions of these receptors in diverse biological systems [12].
  • Furthermore, an increase in the number of chemokine/receptor transgenic and knock-out mice has helped to define the functions of chemokines in vivo [13].
  • Studies in transgenic and knockout mice indicate that IL-1Ra is important in host defense against endotoxin-induced injury [14].
  • The Peg10 knockout mice showed early embryonic lethality owing to defects in the placenta [15].
 

Chemical compound and disease context of Mice, Knockout

 

Biological context of Mice, Knockout

 

Anatomical context of Mice, Knockout

 

Associations of Mice, Knockout with chemical compounds

 

Gene context of Mice, Knockout

  • Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2 [35].
  • Both Msh2- and p53-targeted knockout mice are viable and susceptible to cancer [36].
  • Isl2 knockout mice have an increased ipsilateral projection originating from significantly more RGCs limited to the VTC [37].
  • Here, using heterozygous knockout mice because null mutants are not viable, we report that Igf1r(+/-) mice live on average 26% longer than their wild-type littermates (P < 0.02) [38].
  • Overlapping reading frames in the INK4A/ARF gene encode p16INK4a and a distinct tumour-suppressor protein, p19ARF (ref. 3). Here we describe the generation and characterization of a p16Ink4a-specific knockout mouse that retains normal p19Arf function [39].
 

Analytical, diagnostic and therapeutic context of Mice, Knockout

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