Disease relevance of Simplexvirus

• The antiviral effects of humoral antibodies and adenine arabinoside on encephalitis due to Herpesvirus hominis were studied in three-week-old mice [1].
• The reactivity of the bacterial radical greatly contrasts with that of the viral radical, and the iron centre in herpes-simplex-virus R2 is much more labile than that in E. coli R2, as shown from the facile mobilization of iron by chelators such as catechol [2].
• In vitro antiviral activities of two potentially clinically useful antiviral compounds, adenine arabinoside and iododeoxyuridine, were examined in human fetal intestinal and tracheal organ cultures infected with Herpesvirus hominis (types 1 and 2) or vaccinia virus [3].
• In completed and ongoing clinical trials, adenovirus-mediated (Ad.) expression of herpes-simplex-virus thymidine-kinase (HSV-tk) gene transduction followed by ganciclovir (GCV) therapy has produced limited toxicity and evidence of antitumor activity following injection of the prostate [4].
• Prospects for herpes-simplex-virus thymidine-kinase and cytokine gene transduction as immunomodulatory gene therapy for prostate cancer [4].

Psychiatry related information on Simplexvirus

• Cerebrospinal fluids (CSF) from 35 patients with senile or presenile dementia and from 13 patients with schizophrenia and related syndromes were examined in cell cultures with the aim to isolate Herpesvirus hominis 1 (HVH 1) or other viruses [5].

High impact information on Simplexvirus

• Acyclovir prophylaxis of herpes-simplex-virus infections [6].
• Antibody activity to herpesvirus hominis type 2 (HVH-2) in 151 women cured of cervical carcinoma (60 in situ, 91 invasive) and in 106 controls differed significantly, especially between the in situ (73%) and control (17%) groups [7].
• Effect of adenine arabinoside on severe Herpesvirus hominis infections in man. 1973 [8].
• Commentary: Ch'ien LT, Cannon NJ, Charamella LJ, et al. effect of adenine arabinoside on severe herpesvirus hominis infections in man: preliminary report. J Infect Dis 1973; 128:658-63 [9].
• Effect of treatment with exogenous interferon, polyriboinosinic-polyribocytidylic acid, or polyriboinosinic-polyribocytidylic acid-poly-L-lysine complex on Herpesvirus hominis infections in mice [10].

Chemical compound and disease context of Simplexvirus

• Alteration of mortality and pathogenesis of three experimental Herpesvirus hominis infections of mice with adenine arabinoside 5'-monophosphate, adenine arabinoside, and phosphonoacetic acid [11].
• Herpesvirus hominis infection in newborn mice: treatment with interferon inducer polyinosinic-polycytidylic acid [12].
• One of the thiols, S,2-aminoethylisothiourea, given intraperitoneally, protected mice against two unrelated viruses--Semliki forest virus and Herpesvirus hominis type 1 [13].
• In vitro activity of silver sulfadiazine against Herpesvirus hominis [14].
• Herpesvirus hominis infection in newborn mice: comparison of the therapeutic efficacy of 1-beta-D-arabinofuranosylcytosine and 9-beta-D-arabinofuranosyladenine [15].

Anatomical context of Simplexvirus

• Thymidine kinase activity in cerebrospinal fluid of rabbits with Herpesvirus hominis encephalitis [16].

Gene context of Simplexvirus

• Murine fibroblast-derived VPC expressing herpes-simplex-virus type I thymidine kinase (HSV-tk) were genetically modified to co-express a human Fas ligand (CD95L) deletion mutant (DeltaFasL) resistant to enzymatic cleavage and shedding [17].
• Herpesvirus papio 2 encodes a virion host shutoff function [18].
• Sera were obtained from 985 patients for detection of Type I and II herpesvirus hominis antibodies [19].
• Conversely, D.S.500 increased the resistance of mice to another group of herpes simplex-viruses (strains D-316, Thea, DD), if given 3 to 8 hours before infection [20].
• We have sequenced the thymidine kinase gene of a canine herpesvirus, and with a multiple alignment have identified amino acids preferentially conserved in either of two taxons, the genera Varicellovirus and Simplexvirus, of the subfamily Alphaherpesvirinae [21].

Analytical, diagnostic and therapeutic context of Simplexvirus

• Intradermal tests with a mixture of Herpesvirus hominis 1 (HVH 1) antigens containing quantitated neutralization antigen were done in 39 schizophrenics (SCH), 42 senile demented (DS) persons, 28 alcoholics, neurotics and psychopaths (ANP) and 33 control persons [22].
• An enzyme immunoassay (EIA) was used for the detection of antibodies to Herpesvirus hominis type 1 and 2 (HVH-1 and HVH-2), SA8 and Herpesvirus simiae (HVB) in human and nonhuman primate sera [23].

References