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Disease relevance of Hydrolysis


Psychiatry related information on Hydrolysis


High impact information on Hydrolysis


Chemical compound and disease context of Hydrolysis


Biological context of Hydrolysis


Anatomical context of Hydrolysis

  • The ATP-binding cassette (ABC) transporters are a family of large proteins in membranes and are able to transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis [26].
  • The EC50 for IL-1 was 28 fM, and PC hydrolysis was detectable within 5 sec at 37 degrees C. The murine cell line had typical high-affinity IL-1 receptors (kd = 7 X 10(-11) M) [27].
  • However, after nucleotide hydrolysis is inhibited by vanadate, unidirectional translocation ceases, and microtubules instead undergo irregular back-and-forth motion along their longitudinal axes [28].
  • The question of whether a G protein couples TCR/CD3 to PI hydrolysis and to Ca2+ mobilization is unresolved, although some indirect evidence for the involvement of GTP binding proteins in T cell activation has recently been obtained with cholera toxin [29].
  • The number of elongating form A and B RNA polymerases in chick oviduct nuclei was estimated by measuring incorportaion of 3H-UTP into 3' termini of nascent RNA chains in the presence of heparin to inhibit initiation, and quantitation labeled uridine released from these termini after alkaline hydrolysis [30].

Associations of Hydrolysis with chemical compounds


Gene context of Hydrolysis


Analytical, diagnostic and therapeutic context of Hydrolysis


  1. Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors. Lechleiter, J., Girard, S., Clapham, D., Peralta, E. Nature (1991) [Pubmed]
  2. Biochemistry of the bacterial catabolism of aromatic compounds in anaerobic environments. Evans, W.C. Nature (1977) [Pubmed]
  3. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Guan, K.L., Broyles, S.S., Dixon, J.E. Nature (1991) [Pubmed]
  4. Paraoxonase and coronary heart disease. Mackness, M.I., Mackness, B., Durrington, P.N. Atherosclerosis. Supplements. (2002) [Pubmed]
  5. Escherichia coli hemolysin is a potent inductor of phosphoinositide hydrolysis and related metabolic responses in human neutrophils. Grimminger, F., Sibelius, U., Bhakdi, S., Suttorp, N., Seeger, W. J. Clin. Invest. (1991) [Pubmed]
  6. Actin-dependent mitochondrial motility in mitotic yeast and cell-free systems: identification of a motor activity on the mitochondrial surface. Simon, V.R., Swayne, T.C., Pon, L.A. J. Cell Biol. (1995) [Pubmed]
  7. The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations. Cedazo-Minguez, A., Popescu, B.O., Ankarcrona, M., Nishimura, T., Cowburn, R.F. J. Biol. Chem. (2002) [Pubmed]
  8. Physiological evidence that light-mediated decrease in cyclic GMP is an intermediary process in retinal rod transduction. Miller, W.H. J. Gen. Physiol. (1982) [Pubmed]
  9. The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain. Jope, R.S., Song, L., Li, P.P., Young, L.T., Kish, S.J., Pacheco, M.A., Warsh, J.J. J. Neurochem. (1996) [Pubmed]
  10. Reduced activity of hippocampal group-I metabotropic glutamate receptors in learning-prone rats. Cinque, C., Zuena, A.R., Casolini, P., Ngomba, R.T., Melchiorri, D., Maccari, S., Nicoletti, F., DiGiorgi Gerevini, n.u.l.l., Catalani, A. Neuroscience (2003) [Pubmed]
  11. Genetic and mutational analysis of the T-cell antigen receptor. Ashwell, J.D., Klusner, R.D. Annu. Rev. Immunol. (1990) [Pubmed]
  12. Structural insights into translational fidelity. Ogle, J.M., Ramakrishnan, V. Annu. Rev. Biochem. (2005) [Pubmed]
  13. ATP-binding cassette transporters in bacteria. Davidson, A.L., Chen, J. Annu. Rev. Biochem. (2004) [Pubmed]
  14. Regulation of phosphoinositide-specific phospholipase C. Rhee, S.G. Annu. Rev. Biochem. (2001) [Pubmed]
  15. GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Ross, E.M., Wilkie, T.M. Annu. Rev. Biochem. (2000) [Pubmed]
  16. Concentrations of an activator protein for sphingolipid hydrolysis in liver and brain samples from patients with lysosomal storage diseases. Inui, K., Wenger, D.A. J. Clin. Invest. (1983) [Pubmed]
  17. Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin. Brass, L.F., Shaller, C.C., Belmonte, E.J. J. Clin. Invest. (1987) [Pubmed]
  18. Absorptive and digestive function of the jejunum after jejunoileal bypass for treatment of human obesity. Fogel, M.R., Ravitch, M.M., Adibi, S.A. Gastroenterology (1976) [Pubmed]
  19. Urea metabolism in an azotaemic woman with normal renal function. Richards, P., Brown, C.L. Lancet (1975) [Pubmed]
  20. Enzymic hydrolysis of tampon carboxymethylcellulose and toxic shock syndrome. Tierno, P.M., Hanna, B.A. Lancet (1983) [Pubmed]
  21. The chaperonin ATPase cycle: mechanism of allosteric switching and movements of substrate-binding domains in GroEL. Roseman, A.M., Chen, S., White, H., Braig, K., Saibil, H.R. Cell (1996) [Pubmed]
  22. The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis. Song, H., Mugnier, P., Das, A.K., Webb, H.M., Evans, D.R., Tuite, M.F., Hemmings, B.A., Barford, D. Cell (2000) [Pubmed]
  23. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Raeder, H., Johansson, S., Holm, P.I., Haldorsen, I.S., Mas, E., Sbarra, V., Nermoen, I., Eide, S.A., Grevle, L., Bjørkhaug, L., Sagen, J.V., Aksnes, L., Søvik, O., Lombardo, D., Molven, A., Njølstad, P.R. Nat. Genet. (2006) [Pubmed]
  24. GTPase activity of Rab5 acts as a timer for endocytic membrane fusion. Rybin, V., Ullrich, O., Rubino, M., Alexandrov, K., Simon, I., Seabra, M.C., Goody, R., Zerial, M. Nature (1996) [Pubmed]
  25. Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis. Dove, S.K., Cooke, F.T., Douglas, M.R., Sayers, L.G., Parker, P.J., Michell, R.H. Nature (1997) [Pubmed]
  26. Mammalian ABC transporters in health and disease. Borst, P., Elferink, R.O. Annu. Rev. Biochem. (2002) [Pubmed]
  27. Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism. Rosoff, P.M., Savage, N., Dinarello, C.A. Cell (1988) [Pubmed]
  28. One-dimensional diffusion of microtubules bound to flagellar dynein. Vale, R.D., Soll, D.R., Gibbons, I.R. Cell (1989) [Pubmed]
  29. Calcium and T lymphocyte activation. Gardner, P. Cell (1989) [Pubmed]
  30. Quantitation of elongating form A and B RNA polymerases in chick oviduct nuclei and effects of estradiol. Cox, R.F. Cell (1976) [Pubmed]
  31. Structure and function of hexameric helicases. Patel, S.S., Picha, K.M. Annu. Rev. Biochem. (2000) [Pubmed]
  32. Catalysis by metal-activated hydroxide in zinc and manganese metalloenzymes. Christianson, D.W., Cox, J.D. Annu. Rev. Biochem. (1999) [Pubmed]
  33. Selective recycling of the mannose 6-phosphate/IGF-II receptor to the trans Golgi network in vitro. Goda, Y., Pfeffer, S.R. Cell (1988) [Pubmed]
  34. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254. Kim, H.K., Kim, J.W., Zilberstein, A., Margolis, B., Kim, J.G., Schlessinger, J., Rhee, S.G. Cell (1991) [Pubmed]
  35. Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis. Larrodera, P., Cornet, M.E., Diaz-Meco, M.T., Lopez-Barahona, M., Diaz-Laviada, I., Guddal, P.H., Johansen, T., Moscat, J. Cell (1990) [Pubmed]
  36. ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity. Brown, H.A., Gutowski, S., Moomaw, C.R., Slaughter, C., Sternweis, P.C. Cell (1993) [Pubmed]
  37. An intrinsic adenylate kinase activity regulates gating of the ABC transporter CFTR. Randak, C., Welsh, M.J. Cell (2003) [Pubmed]
  38. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Martinez-Botas, J., Anderson, J.B., Tessier, D., Lapillonne, A., Chang, B.H., Quast, M.J., Gorenstein, D., Chen, K.H., Chan, L. Nat. Genet. (2000) [Pubmed]
  39. Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis. Goldberg, J. Cell (1999) [Pubmed]
  40. LMA1 binds to vacuoles at Sec18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion. Xu, Z., Sato, K., Wickner, W. Cell (1998) [Pubmed]
  41. Deterioration of the seventeenth-century warship Vasa by internal formation of sulphuric acid. Sandström, M., Jalilehvand, F., Persson, I., Gelius, U., Frank, P., Hall-Roth, I. Nature (2002) [Pubmed]
  42. Extent of DNA methylation in human tumor cells. Diala, E.S., Cheah, M.S., Rowitch, D., Hoffman, R.M. J. Natl. Cancer Inst. (1983) [Pubmed]
  43. L-carnitine therapy in isovaleric acidemia. Roe, C.R., Millington, D.S., Maltby, D.A., Kahler, S.G., Bohan, T.P. J. Clin. Invest. (1984) [Pubmed]
  44. Intestinal assimilation of a proline-containing tetrapeptide. Role of a brush border membrane postproline dipeptidyl aminopeptidase IV. Morita, A., Chung, Y.C., Freeman, H.J., Erickson, R.H., Sleisenger, M.H., Kim, Y.S. J. Clin. Invest. (1983) [Pubmed]
  45. Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine. Høyvik, H., Gordon, P.B., Berg, T.O., Strømhaug, P.E., Seglen, P.O. J. Cell Biol. (1991) [Pubmed]
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