Disease relevance of Chromoblastomycosis

• Monitoring of extracellular matrix metabolism and cross-linking in tissue, serum and urine of patients with chromoblastomycosis, a chronic skin fibrosis [1].
• Itraconazole is less effective in the treatment of chromomycosis and coccidioidomycosis [2].
• Flucytosine has a narrower spectrum of activity (cryptococcosis, candidosis, cladosporiosis, and chromomycosis) but a preferable route of administration (oral) [3].
• Potassium iodide is used to treat lymphocutaneous sporotrichosis, bronchopulmonary geotrichosis and chromoblastomycosis [4].
• The authors present the use of ketoconazole in 27 cases of paracoccidioidomycosis, eight of mycetoma, seven of chromomycosis, four of systemic candidiasis and one of lobomycosis [5].

High impact information on Chromoblastomycosis

• The structural difference between cerebrosides from mycelial and sclerotic cells was apparently not relevant for their antigenicity, since they were both recognized at similar levels by sera from individuals with chromoblastomycosis and a monoclonal antibody to a conserved cerebroside structure [6].
• Adrenal response to corticotrophin and testosterone during long-term therapy with itraconazole in patients with chromoblastomycosis [7].
• Parenteral vitamin D(3) and oral terbinafine for refractory chromoblastomycosis [8].
• In 2 cases of cutaneous chromomycosis, potassium hydroxide preparations of lesional crust/scale easily revealed characteristic Medlar bodies [9].
• Treatment of chromomycosis with oral high-dose amphotericin B [10].

Chemical compound and disease context of Chromoblastomycosis

• In an open trial, long courses (6-12 months) of terbinafine at a dosage of 500 mg/day were administered orally to 43 patients with a diagnosis of chromomycosis [11].
• Treatment of chromomycosis with ketoconazole and 5-fluorocytosine [12].
• The chromomycosis responded to local excision and ketoconazole therapy [13].
• Treatment of chronic murine chromoblastomycosis with the triazole SCH39304 [14].
• These studies confirm clinical observations that itraconazole is effective in chromoblastomycosis and suggest that SCH39304 should be considered for clinical evaluation [14].

Biological context of Chromoblastomycosis

• Primers having designs based on highly conserved stretches in the deduced amino acid sequences of chitin synthase (CHS) genes were used in PCR reactions to amplify 600 bp and 366 bp products from the genomic DNA of three major causal agents of chromoblastomycosis [15].

Anatomical context of Chromoblastomycosis

• In chromomycosis, HSP 27 is expressed, in accordance with its role as a marker of differentiation and proliferation, in keratinocytes and also in F. pedrosoi [16].

Gene context of Chromoblastomycosis

• The distribution of 12 HLA-A, 14 HLA-B, seven HLA-C, seven HLA-DR and three HLA-DQ antigens was determined in 32 non-consanguineous white Brazilians suffering from chromoblastomycosis and 77 healthy controls, matched for ethnic background, sex and age and living in the same geographical area [17].
• Subcutaneous chromoblastomycosis occurring in a patient with systemic lupus erythematosus [18].

Analytical, diagnostic and therapeutic context of Chromoblastomycosis

• Patients with long-standing chromoblastomycosis may respond poorly to standard treatments such as amphotericin B, oral antifungals, surgical measures or thermotherapy [19].
• METHODS: We tested sera from 25 patients with clinical and histologic diagnosis of chromomycosis for the presence of ANCA by indirect immunofluorescence [20].
• Treatment of chromomycosis by cryosurgery with liquid nitrogen: 15 years' experience [21].
• Detection of antibodies in the sera of patients with chromoblastomycosis by counter immunoelectrophoresis. I. Preliminary results [22].
• The antibodies in sera of patients affected by Chromoblastomycosis are detected using the technique of double immunodiffusion and the mycelial somatic antigens and the culture filtrates antigens of Cladosporium carrionii [23].

References