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MeSH Review

Abortion, Missed

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Disease relevance of Abortion, Missed


High impact information on Abortion, Missed

  • Women with missed abortion (n = 56), blighted ovum (n = 36), or tubal pregnancy (n = 7) were selected by means of vaginal ultrasonographic examination from a population seeking early pregnancy termination; 140 women with amenorrhea-matched normal gestation were studied as controls [6].
  • PATIENT(S): Twenty-three women who had conceived by IVF and had a missed abortion before 12 weeks of gestation [7].
  • PATIENT(S): All IVF patients with missed abortions undergoing uterine curettage [8].
  • SETTING: Instituto Valenciano de Infertilidad, Valencia, Spain. PATIENT(S): Sixty-eight women (71 gestational sacs) with missed abortions [9].
  • OBJECTIVE: To estimate the efficacy of vaginal misoprostol for medical management of missed abortion [10].

Chemical compound and disease context of Abortion, Missed


Biological context of Abortion, Missed


Anatomical context of Abortion, Missed


Gene context of Abortion, Missed

  • The basal PRL levels did not differ between the women with normal early pregnancy (N = 15), blighted ovum (N = 13), or with missed abortion (N = 11) [19].
  • Diminished decidual IL-10 staining was noted in 7/10 missed abortion cases compared with none of the elective termination cases (n = 12) (P = 0.007) [20].
  • RESULTS: P, E2, total T, and SHBG in 22 patients with missed abortion were significantly lower than those in normal group, whereas % free T was significantly higher [21].
  • CONCLUSION: Decreased IL-10 production coupled with a sustained IFN-gamma presence noted in missed abortion compared with elective termination cases suggest that these cytokines may be important determinants in pregnancy outcome [20].
  • OBJECTIVE: To describe a patient with congenital cervical atresia who became pregnant through IVF and thawed transmyometrial ET and then experienced a missed abortion [22].

Analytical, diagnostic and therapeutic context of Abortion, Missed


  1. Placental changes in a first trimester missed abortion in maternal systemic lupus erythematosus with antiphospholipid syndrome; a case report and review of the literature. Nayar, R., Lage, J.M. Hum. Pathol. (1996) [Pubmed]
  2. Induction of labor in patients with missed abortion and fetal death in utero with protaglandin E2 suppositories. Lauersen, N.H., Wilson, K.H. Am. J. Obstet. Gynecol. (1977) [Pubmed]
  3. VEGF, its receptors and the tie receptors in recurrent miscarriage. Vuorela, P., Carpén, O., Tulppala, M., Halmesmäki, E. Mol. Hum. Reprod. (2000) [Pubmed]
  4. The use of prostaglandin E2 vaginal suppository in missed abortion, intrauterine death and hydatidiform mole. Takagi, L.R., Gulling, E.A., O'Leary, J.A. Journal of the Medical Association of Georgia. (1978) [Pubmed]
  5. Measurement of intrauterine human decidua-associated protein 200 and diagnosis of ectopic pregnancy. Halperin, R., Hadas, E., Bukovsky, I., Schneider, D. Gynecol. Obstet. Invest. (1998) [Pubmed]
  6. Increased release of cervical nitric oxide in spontaneous abortion before clinical symptoms: a possible mechanism for preabortal cervical ripening. Väisänen-Tommiska, M., Mikkola, T.S., Ylikorkala, O. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  7. Abnormal embryonic development diagnosed embryoscopically in early intrauterine deaths after in vitro fertilization: a preliminary report of 23 cases. Philipp, T., Feichtinger, W., Van Allen, M.I., Separovic, E., Reiner, A., Kalousek, D.K. Fertil. Steril. (2004) [Pubmed]
  8. Rate of aneuploidy in miscarriages following in vitro fertilization and intracytoplasmic sperm injection. Lathi, R.B., Milki, A.A. Fertil. Steril. (2004) [Pubmed]
  9. Improved accuracy of hysteroembryoscopic biopsies for karyotyping early missed abortions. Ferro, J., Martínez, M.C., Lara, C., Pellicer, A., Remohí, J., Serra, V. Fertil. Steril. (2003) [Pubmed]
  10. Medical management of missed abortion: a randomized clinical trial. Wood, S.L., Brain, P.H. Obstetrics and gynecology. (2002) [Pubmed]
  11. Intramuscular (15S)-15-methyl prostaglandin F2alpha for midtrimester and missed abortions. Sharma, S.D., Hale, R.W., Sato, N.E. Obstetrics and gynecology. (1975) [Pubmed]
  12. Management of intrauterine fetal demise and missed abortion using prostaglandin E2 vaginal suppositories. Southern, E.M., Gutknecht, G.D. Obstetrics and gynecology. (1976) [Pubmed]
  13. Unsuccessful treatment of missed abortion with a combination of an antiprogesterone and a prostaglandin E1 analogue. Nielsen, S., Hahlin, M., Platz-Christensen, J.J. British journal of obstetrics and gynaecology. (1997) [Pubmed]
  14. Termination of abnormal intrauterine pregnancies with intramuscular administration of dihomo 15 methyl prostaglandin F 2alpha. Karim, S.M., Ratnam, S.S. British journal of obstetrics and gynaecology. (1976) [Pubmed]
  15. Propranolol for the treatment of hypertension in pregnancy. Eliahou, H.E., Silverberg, D.S., Reisin, E., Romem, I., Mashiach, S., Serr, D.M. British journal of obstetrics and gynaecology. (1978) [Pubmed]
  16. Platelet function, coagulation and fibrinolysis during termination of missed abortion and missed labor by PGF2 alpha and oxytocin. Briel, R.C., Kunz, S., Kidess, E. Acta obstetricia et gynecologica Scandinavica. (1979) [Pubmed]
  17. Continuous monitoring of uterine contractions to control intra-amniotic administration of prostaglandin F2 alpha for therapeutic and missed abortion. Roux, C.J., Odendaal, H.J. S. Afr. Med. J. (1981) [Pubmed]
  18. Intracervical instillation of PGE2-gel in patients with missed abortion or intrauterine fetal death. Ekman, G., Uldbjerg, N., Wingerup, L., Ulmsten, U. Arch. Gynecol. (1983) [Pubmed]
  19. Role of maternal prolactin in early pregnancy failure. Jouppila, P., Ylikorkala, O. Obstetrics and gynecology. (1984) [Pubmed]
  20. Deficiency of decidual IL-10 in first trimester missed abortion: a lack of correlation with the decidual immune cell profile. Plevyak, M., Hanna, N., Mayer, S., Murphy, S., Pinar, H., Fast, L., Ekerfelt, C., Ernerudh, J., Berg, G., Matthiesen, L., Sharma, S. Am. J. Reprod. Immunol. (2002) [Pubmed]
  21. Free testosterone and abortion in early pregnancy. Takeuchi, T., Nishii, O., Okamura, T., Yaginuma, T., Kawana, T. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (1993) [Pubmed]
  22. Management of missed abortion in a patient with congenital cervical atresia. Suganuma, N., Furuhashi, M., Moriwaki, T., Tsukahara, S., Ando, T., Ishihara, Y. Fertil. Steril. (2002) [Pubmed]
  23. Comparative study of extra-amniotic prostaglandin F2 alpha infusion and increasing intravenous oxytocin for termination of second trimester missed abortion. Jaschevatzky, O.E., Rosenberg, R.P., Noy, Y., Dascalu, S., Anderman, S., Ballas, S. J. Am. Coll. Surg. (1994) [Pubmed]
  24. Pregnancy in patients with systemic lupus erythematosus. Varner, M.W., Meehan, R.T., Syrop, C.H., Strottmann, M.P., Goplerud, C.P. Am. J. Obstet. Gynecol. (1983) [Pubmed]
  25. Serum levels of polychlorinated biphenyls and some organochlorine insecticides in women with recent and former missed abortions. Bercovici, B., Wassermann, M., Cucos, S., Ron, M., Wassermann, D., Pines, A. Environmental research. (1983) [Pubmed]
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