Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Thyroglossal Cyst

Kreft, A., Ein, S.H., Naghavi, S.E., Knight, P.J., Lim-Dunham, J.E., et al.

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Disease relevance of Thyroglossal Cyst

Midline cystic lesions are most commonly thyroglossal duct cysts, although dermoid tumors are also frequently midline [1].
CONCLUSIONS: Base upon our past and current experience,we recommend that thyroglossal duct cyst with a microscopic focus of papillary carcinoma without cyst wall invasion be managed with Sistrunk procedure along with effective suppressant dose of thyroxine [2].
Failures of descent of the medial anlage of the thyroid and incomplete obliteration of its vertical tract lead to midline or near-midline ectopias such as lingual thyroid and thyroglossal cysts [3].

High impact information on Thyroglossal Cyst

Only recurrence following prior excision and persistent sinus following drainage of a midline cyst were pathognomonic preoperative indicators of a thyroglossal duct cyst; these findings were present in only 6% of the cases [4].
Five in ten cases of thyroglossal duct cysts were positive for TTF-1, but all were negative for TG [5].
There were an estimated 1102 thyroglossal duct cyst excisions, making this the most common HNE procedure and diagnosis [6].
Thyroid transcription factor 1 expression in cystic lesions of the neck: an immunohistochemical investigation of thyroglossal duct cysts, branchial cleft cysts and metastatic papillary thyroid cancer [5].
BACKGROUND AND OBJECTIVE: Well-differentiated thyroid carcinoma (WDTC) is diagnosed in approximately 1.5% of thyroglossal duct cysts (TGDC) [7].

Chemical compound and disease context of Thyroglossal Cyst

Cholesterol-rich thyroglossal cyst: report of a case diagnosed by fine needle aspiration [8].
Preoperative sonographic identification of a normal thyroid gland in patients with thyroglossal duct cyst confirms a source of thyroid hormone separate from the thyroglossal duct cyst and thus excludes ectopic thyroid [9].

Anatomical context of Thyroglossal Cyst

The solution to these recurrent thyroglossal duct cysts and sinuses were deeper excisions to remove residual tracts deep to the previously removed hyoid bone, and/or wider excisions to excise previously missed respiratory epithelial remnants which deviated laterally from the midline [10].

Gene context of Thyroglossal Cyst

F-18 FDG PET demonstration of thyroglossal duct cyst [11].

References

Imaging of cystic lesions. Lev, S., Lev, M.H. Radiol. Clin. North Am. (2000)
Papillary carcinoma of thyroglossal duct cyst. Naghavi, S.E., Jalali, M.M. Med. Sci. Monit. (2003)
Thyroid gland ectopias. Batsakis, J.G., El-Naggar, A.K., Luna, M.A. The Annals of otology, rhinology, and laryngology. (1996)
The diagnosis and treatment of midline neck masses in children. Knight, P.J., Hamoudi, A.B., Vassy, L.E. Surgery (1983)
Thyroid transcription factor 1 expression in cystic lesions of the neck: an immunohistochemical investigation of thyroglossal duct cysts, branchial cleft cysts and metastatic papillary thyroid cancer. Kreft, A., Hansen, T., Kirkpatrick, C.J. Virchows Arch. (2005)
Head and neck endocrine surgery in children: 1997 and 2000. Harsha, W.J., Perkins, J.A., Lewis, C.W., Manning, S.C. Arch. Otolaryngol. Head Neck Surg. (2005)
Management of well-differentiated thyroid carcinoma presenting within a thyroglossal duct cyst. Patel, S.G., Escrig, M., Shaha, A.R., Singh, B., Shah, J.P. Journal of surgical oncology. (2002)
Cholesterol-rich thyroglossal cyst: report of a case diagnosed by fine needle aspiration. Chow, L.T., Lee, J.C., Chow, W.H., Chan, S.K. Acta Cytol. (1996)
Sonographic demonstration of a normal thyroid gland excludes ectopic thyroid in patients with thyroglossal duct cyst. Lim-Dunham, J.E., Feinstein, K.A., Yousefzadeh, D.K., Ben-Ami, T. AJR. American journal of roentgenology. (1995)
The problem of recurrent thyroglossal duct remnants. Ein, S.H., Shandling, B., Stephens, C.A., Mancer, K. J. Pediatr. Surg. (1984)
F-18 FDG PET demonstration of thyroglossal duct cyst. Nguyen, B.D. Clinical nuclear medicine. (2005)