Disease relevance of Minor Lymphocyte Stimulatory Loci

• Experimental immunologically mediated aplastic anemia (AA) in H-2k identical, Mls (M) locus different mice [1].

High impact information on Minor Lymphocyte Stimulatory Loci

• Parent yields F1 and F1 yields parent combinations are as effective as syngeneic systems, but mice given allogeneic immune cells survive as long as controlsmdifferences at the M-locus in H-2 compatible mice do not inhibit effector activity [2].
• The allogeneic effect: M-locus differences substitute for differences in the H-2 major histocompatibility complex [3].
• Thus, there seems to be a dichotomy in allogeneic determinants between those of the I region and of the M locus inducing primarily lymphoproliferation, and those of H-2K and H-2D inducing cytotoxic activity and interferon production [4].
• Interferon production in the murine mixed lymphocyte culture. I. Interferon production caused by differences in the H-2 K and H-2 D region but not by differences in the I region or the M locus [4].
• Proliferative responses to M locus (Mls) determinants were investigated in vivo by injecting T cell-containing populations intravenously into irradiated H2-identical, Mls-incompatible mice [5].

Biological context of Minor Lymphocyte Stimulatory Loci

• The result assigns TCP1B to a bovine linkage group previously comprising major histocompatibility complex class I and class II genes and blood group locus M [6].

Anatomical context of Minor Lymphocyte Stimulatory Loci

• Surprisingly the M-locus different spleen cells were almost as efficient in enhancing the anti-sheep red blood cell response in nude cultures as were the cells differing on the complete H-2 complex [3].

Associations of Minor Lymphocyte Stimulatory Loci with chemical compounds

• This is the first evidence that ethylene signals may influence the product of the M locus and thus inhibit stamen development in cucumber [7].
• Positional cloning of M has revealed that it encodes a membrane-anchored cytoplasmic serine/threonine protein kinase, designated M locus protein kinase (MLPK) [8].

Gene context of Minor Lymphocyte Stimulatory Loci

• Disruption of the lysozyme M locus significantly increased bacterial burden and mortality following intratracheal infection with a Gram-negative bacterium [9].
• The role of gene products of non-H-2 loci and M locus in secondary MLC response [10].
• Effect on graft-versus-host response of donor mouse preimmunization with M-locus and DBA/2 (DAG) antigens [proceedings] [11].

References