Psychiatry related information on Pair Bond

• Although dopamine is necessary for mammalian adult pair-bond formation and maternal behavior, its function in infant social behavior and attachment has been less thoroughly explored [1].

High impact information on Pair Bond

• OT exerts potent antistress effects that may facilitate pair bonds [2].
• Nucleus accumbens dopamine differentially mediates the formation and maintenance of monogamous pair bonds [3].
• Due to steric hindrance, an adenine-thymine-type hydrogen bond pair is formed only at potentials more positive than 0.1 V (vs SCE) where the unprotonated adenine moiety is perpendicularly oriented [4].
• These results suggest possible sites of action for CRF-induced facilitation of pair bond formation in prairie voles, as well as potential sex differences in the CRF modulation of pair bonding [5].
• However, it is unclear which brain circuits are involved in this vasopressin-mediated facilitation of pair bond formation [6].

Chemical compound and disease context of Pair Bond

• Concurrent activation of neuropeptide and dopamine receptors in the reward centers of the brain during mating results in a conditioned partner preference, observed as a pair bond [7].
• These receptors have also been implicated in the behavioral differences relevant to monogamy, as oxytocin and vasopressin influence pair-bond formation in the monogamous species [8].
• Results confirmed that cortisol concentrations were reduced following the establishment of a pair-bond and found that P. campbelli males had elevated cortisol before the birth [9].
• Pair bond formation occurred between September and December and was associated with an increase in levels of plasma LH but no change in plasma estradiol [10].
• However, many investigations indicate that pair bonds in nonsexual contexts are not regulated by testosterone [11].

Biological context of Pair Bond

• For example, OT has been implicated in parturition, lactation, maternal behavior and pair bond formation [12].

Anatomical context of Pair Bond

• The involvement of dopamine within the nucleus accumbens in the formation and maintenance of pair bonds was assessed in a series of experiments using the monogamous prairie vole [3].
• Next, we infused a selective V1aR antagonist into three candidate brain regions that seemed most likely involved in vasopressin-mediated pair bond formation: the ventral pallidum, medial amygdala, and MDthal [6].
• Facilitation of affiliation and pair-bond formation by vasopressin receptor gene transfer into the ventral forebrain of a monogamous vole [13].

Gene context of Pair Bond

• Oxytocin, vasopressin, and the neuroendocrine basis of pair bond formation [14].
• In males, it is AVP (not OT) that appears necessary for pair bond formation [15].
• Arginine vasopressin and its V1a receptor subtype (V1aR) are critical for pair bond formation between adult prairie voles [6].
• Endogenous gonadal, LH and molt rhythms in tropical stonechats: effect of pair bond on period, amplitude, and pattern of circannual cycles [16].
• Structural analysis of the FVIII A domain homology model allowed us to identify residues 664 and 1826 as a potential disulfide bond pair [17].

Analytical, diagnostic and therapeutic context of Pair Bond

• In females, this decline in corticosterone may contribute to pair bonding, since corticosterone injections inhibit, and adrenalectomy is associated with a facilitation of pair bond formation [18].

References