Disease relevance of Blood Gas Monitoring, Transcutaneous

• In the 76 gold standard children, Pes, tcPCO2, and expired CO2 measurements were in agreement for 1512 of the 1848 apneas and hypopneas that were analyzed [1].
• During the open TcM period, there was significantly less hypoxia (PtcO2 less than 50 torr) (9.0 +/- 3.7% vs 16.3 +/- 4.2%, p less than .025) but no difference in hyperoxia (PtcO2 greater than 100 torr) [2].
• Although the fall in tcPCO2 associated with panic was not substantial and did not indicate clinically significant acute hyperventilation, it appears to be a sensitive index for epinephrine-induced panic [3].
• The effect of a hypo-osmolar aerosol on transcutaneous O2 and CO2 time course (PtcO2, PtcCO2) was investigated in subjects affected by chronic non-atopic rhinitis, without any history of asthmatic symptoms and no airways hyper-responsiveness [4].
• Simultaneous measurements of tissue PCO2 (PtCO2), interstitial H+ concentration ([H+]o), and tissue lactate content were used to examine changes in interstitial HCO3- concentration ([HCO3-]o) during complete ischemia [5].

High impact information on Blood Gas Monitoring, Transcutaneous

• However, direct measures of local cutaneous perfusion, estimated by periwound measurements of transcutaneous O2 tension (TcPo2) and transcutaneous CO2 tension (TcPco2), were significantly associated with the initial rate of tissue repair (P = 0.003 and 0.005, respectively) [6].
• PtcO2 correlated with O2 delivery in only seven severely ill patients mean alveolar-arterial oxygen tension difference [A-aDO2] was 380 mmHg and the pulmonary shunt was 37%) [7].
• Conflicting results exist on the relationship between lactate and PtCO2 [8].
• Maximal flow at functional residual capacity (VmaxFRC) and transcutaneous oxygen tension (Ptco2) were measured at baseline and after methacholine inhalation [9].
• The rapid increase of PtCO2 correlated well with increasing values of lactate (r2 >.9) in the tissue [10].

Chemical compound and disease context of Blood Gas Monitoring, Transcutaneous

• Chronic venous insufficiency of the lower limbs: suitability of transcutaneous blood gas monitoring as an endpoint to evaluate the outcome of pharmacological treatment with calcium dobesilate [11].

Biological context of Blood Gas Monitoring, Transcutaneous

• During bronchoconstriction, induced by a wide range of inhaled methacholine concentrations (0.5-256 g/l), the rise in Rrs6 was reflected by a fall in PtcO2 in all subjects [12].
• The weighted mean correlation coefficients between PtcO2 and O2 delivery as well as between PtcO2 and cardiac output were 0.94 and 0.96, respectively [13].
• Of the 7040 upper airway resistance events, only 2314 events were consonant in all three measures. tcPCO2 identified only 33% of the increased respiratory events identified by Pes; expired CO2 identified only 53% of the same events [1].
• Heart rate (HR), transcutaneous partial pressures of oxygen and carbon dioxide (tcPO2 and tcPCO2), arterial O2 saturation (saO2), and mean arterial blood pressure (MABP) were measured simultaneously [14].
• The influence of lumbar extradural blockade with 0.5% pain bupivacaine on transcutaneous oxygen tension (PtcO2) and skin temperature was studied in 20 patients, 10 scheduled for vascular surgery and 10 for urological surgery [15].

Anatomical context of Blood Gas Monitoring, Transcutaneous

• Normal preterm infants displayed asynchronous chest wall movements only in AS, whereas, in infants with BPD, asynchrony predominated in both sleep states, although O2 saturation and TcPCO2 did not differ between sleep states in either group [16].
• The PtcO2 index (transcutaneous oxygen tension/arterial PO2), measured in the upper extremity, rose (p less than 0.05) after indomethacin infusion, but was almost unchanged in the controls [17].
• Serum ECP was found to be related to blood eosinophils (r = 0.7, p = 0.003); despite the eosinophils, serum ECP proved to be related to a drop in both FEV1 and PtcO2, atr = 0.6 (p = 0.024) and r = 0.7 (p = 0.006), respectively [18].

Associations of Blood Gas Monitoring, Transcutaneous with chemical compounds

• Respiratory resistance (Rrs6), transcutaneous oxygen tension (PtcO2), and oxygen saturation (SaO2) were measured during methacholine challenge in 15 asthmatic children and six normal adults [12].
• We then analyzed the simultaneously measured tcPCO2 and expired CO2 levels to ascertain their ability to identify these same events [1].
• Low PtcO2 values are associated with low values of PlO2, DO2, VO2, and rising lactic acid concentrations in dogs [19].
• The value of continuous transcutaneous oxygen (PtcO2) monitoring in the presence of halothane and nitrous oxide (N2O) was studied in 10 infants [20].
• RESULTS: At 60 min after the administration of acetazolamide, the PtCO2 peaked at more than 60 mmHg, and although it decreased by 90 min, it then remained stable above the baseline value [21].

Gene context of Blood Gas Monitoring, Transcutaneous

• A single carbohydrate-rich meal does not have an immediate impact on PtCO2 in stable COPD [22].
• On the other hand, the patients in group R had significantly lower P50 values, and their PtcO2 values decreased at a greater incline with the lowering of FIO2 than those in group S [23].
• A comparative analysis of transcutaneous oximetry (tcPO2) during oxygen inhalation and leg dependency in severe peripheral arterial occlusive disease [24].
• The transcutaneous index (TCI = PtcO2/arterial oxygen tension [PaO2]) is known to depend both on age and on cardiac index but is assumed to be independent of other physiologic variables [25].
• Comparison of the 12-h period in which PtcO2 data were available (open TcM) with the period in which they were withheld showed no difference in the number of ABG determinations (6.3 +/- 0.6 vs 7.4 +/- 1.0/12 h) [2].

Analytical, diagnostic and therapeutic context of Blood Gas Monitoring, Transcutaneous

• It was therefore concluded that the measurement of PtcO2, but not SaO2, during methacholine challenge can be used for the assessment of bronchial responsiveness, and that it could prove particularly useful for children too young to cooperate with lung function tests [12].
• However, during HBO2, tcPO2 was substantially and significantly higher (409.8+/-98.8 mm Hg) after sympathectomy compared with that after isotonic sodium chloride solution injection (171.3+/-38.1 mm Hg). tcPCO2 did not change significantly after sympathectomy or during HBO2 [26].
• The subset of survivors and those with high Glasgow Coma Scale had greater than normal cardiac index responses (4.02 +/- 0.01 (SEM) L/min/m2, p < 0.01 versus normal) and better tissue oxygenation (217 +/- 2 mmHg PtcO2/FiO2) than nonsurvivors (70 +/- 3 mmHg, p < 0.01) and those with low Glasgow Coma Scale (160 +/- 2, p < 0.05) [27].
• PATIENTS AND METHODS: A consecutively monitored series of 60 severely injured patients were prospectively monitored by cardiac output, pulse oximetry (Sapo2), and transcutaneous O2 and co2 (Ptco2 and Ptc(co2)) sensors immediately after emergency admission [28].
• Tissue perfusion and neovascularization were assessed by angiography, transcutaneous oximetry (TcpO2), tritiated thymidine uptake combined with autoradiography, and histologic capillary density measurements [29].

References