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MeSH Review

HL-60 Cells

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Disease relevance of HL-60 Cells


High impact information on HL-60 Cells


Chemical compound and disease context of HL-60 Cells


Biological context of HL-60 Cells


Anatomical context of HL-60 Cells


Associations of HL-60 Cells with chemical compounds


Gene context of HL-60 Cells


Analytical, diagnostic and therapeutic context of HL-60 Cells


  1. Dynamic redistribution of raft domains as an organizing platform for signaling during cell chemotaxis. Gómez-Moutón, C., Lacalle, R.A., Mira, E., Jiménez-Baranda, S., Barber, D.F., Carrera, A.C., Martínez-A, C., Mañes, S. J. Cell Biol. (2004) [Pubmed]
  2. A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo. Porkka, K., Laakkonen, P., Hoffman, J.A., Bernasconi, M., Ruoslahti, E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Capsaicin inhibits preferentially the NADH oxidase and growth of transformed cells in culture. Morré, D.J., Chueh, P.J., Morré, D.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  4. CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs. Fang, G., Kim, C.N., Perkins, C.L., Ramadevi, N., Winton, E., Wittmann, S., Bhalla, K.N. Blood (2000) [Pubmed]
  5. Downregulation of Wilms' tumor gene (wt1) during myelomonocytic differentiation in HL60 cells. Sekiya, M., Adachi, M., Hinoda, Y., Imai, K., Yachi, A. Blood (1994) [Pubmed]
  6. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Nguyen, H.Q., Hoffman-Liebermann, B., Liebermann, D.A. Cell (1993) [Pubmed]
  7. Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Loetscher, H., Pan, Y.C., Lahm, H.W., Gentz, R., Brockhaus, M., Tabuchi, H., Lesslauer, W. Cell (1990) [Pubmed]
  8. PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15). Larsen, E., Palabrica, T., Sajer, S., Gilbert, G.E., Wagner, D.D., Furie, B.C., Furie, B. Cell (1990) [Pubmed]
  9. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells. Bories, D., Raynal, M.C., Solomon, D.H., Darzynkiewicz, Z., Cayre, Y.E. Cell (1989) [Pubmed]
  10. c-fos expression is neither sufficient nor obligatory for differentiation of monomyelocytes to macrophages. Mitchell, R.L., Henning-Chubb, C., Huberman, E., Verma, I.M. Cell (1986) [Pubmed]
  11. Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells. Brandt, S.J., Dougherty, R.W., Lapetina, E.G., Niedel, J.E. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  12. Effects of endogenously activated transforming growth factor-beta on growth and differentiation of retinoic acid-treated HL-60 cells. Nunes, I., Kojima, S., Rifkin, D.B. Cancer Res. (1996) [Pubmed]
  13. Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells. Ibrado, A.M., Huang, Y., Fang, G., Liu, L., Bhalla, K. Cancer Res. (1996) [Pubmed]
  14. Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites. Elias, L., Crissman, H.A. Cancer Res. (1988) [Pubmed]
  15. Relationship of acivicin-induced monocytoid differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression. Weinberg, J.B., Mason, S.N. Cancer Res. (1991) [Pubmed]
  16. Molecular cloning and expression of the major protein kinase C substrate of platelets. Tyers, M., Rachubinski, R.A., Stewart, M.I., Varrichio, A.M., Shorr, R.G., Haslam, R.J., Harley, C.B. Nature (1988) [Pubmed]
  17. Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter. Bouchard, C., Dittrich, O., Kiermaier, A., Dohmann, K., Menkel, A., Eilers, M., Lüscher, B. Genes Dev. (2001) [Pubmed]
  18. Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis. Ajmani, A.K., Satoh, M., Reap, E., Cohen, P.L., Reeves, W.H. J. Exp. Med. (1995) [Pubmed]
  19. Characterization of the cell surface receptor for human granulocyte/macrophage colony-stimulating factor. Park, L.S., Friend, D., Gillis, S., Urdal, D.L. J. Exp. Med. (1986) [Pubmed]
  20. Transcriptional and posttranscriptional regulation of macrophage-specific colony stimulating factor gene expression by tumor necrosis factor. Involvement of arachidonic acid metabolites. Sherman, M.L., Weber, B.L., Datta, R., Kufe, D.W. J. Clin. Invest. (1990) [Pubmed]
  21. The chemotactic receptor for human C5a anaphylatoxin. Gerard, N.P., Gerard, C. Nature (1991) [Pubmed]
  22. Appearance of a new nucleosomal protein during differentiation of human leukemia (HL-60) cells. Chou, R.H., Chervenick, P.A., Barch, D.R. Science (1984) [Pubmed]
  23. Phospholipase D: a downstream effector of ARF in granulocytes. Cockcroft, S., Thomas, G.M., Fensome, A., Geny, B., Cunningham, E., Gout, I., Hiles, I., Totty, N.F., Truong, O., Hsuan, J.J. Science (1994) [Pubmed]
  24. A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells. Franzoso, G., Biswas, P., Poli, G., Carlson, L.M., Brown, K.D., Tomita-Yamaguchi, M., Fauci, A.S., Siebenlist, U.K. J. Exp. Med. (1994) [Pubmed]
  25. Stimulation by leukotriene D4 of increases in the cytosolic concentration of calcium in dimethylsulfoxide-differentiated HL-60 cells. Baud, L., Goetzl, E.J., Koo, C.H. J. Clin. Invest. (1987) [Pubmed]
  26. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y., Shimizu, T. Nature (1997) [Pubmed]
  27. Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity. Rosenberg, H.F., Ackerman, S.J., Tenen, D.G. J. Exp. Med. (1989) [Pubmed]
  28. Growth control or terminal differentiation: endogenous production and differential activities of vitamin A metabolites in HL-60 cells. Eppinger, T.M., Buck, J., Hämmerling, U. J. Exp. Med. (1993) [Pubmed]
  29. Role of transferrin, Fe, and transferrin receptors in myeloid leukemia cell growth. Studies with an antitransferrin receptor monoclonal antibody. Taetle, R., Rhyner, K., Castagnola, J., To, D., Mendelsohn, J. J. Clin. Invest. (1985) [Pubmed]
  30. Potentiation by 1-alpha,25-dihydroxyvitamin D3 of cytotoxicity to HL-60 cells produced by cytarabine and hydroxyurea. Studzinski, G.P., Bhandal, A.K., Brelvi, Z.S. J. Natl. Cancer Inst. (1986) [Pubmed]
  31. Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Geng, J.G., Bevilacqua, M.P., Moore, K.L., McIntyre, T.M., Prescott, S.M., Kim, J.M., Bliss, G.A., Zimmerman, G.A., McEver, R.P. Nature (1990) [Pubmed]
  32. Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Xu, D., Popov, N., Hou, M., Wang, Q., Björkholm, M., Gruber, A., Menkel, A.R., Henriksson, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  33. Granule membrane protein 140 (GMP140) binds to carcinomas and carcinoma-derived cell lines. Aruffo, A., Dietsch, M.T., Wan, H., Hellström, K.E., Hellström, I. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  34. Cyclic AMP-independent activation of transcription factor NF-kappa B in HL60 cells by tumor necrosis factors alpha and beta. Hohmann, H.P., Kolbeck, R., Remy, R., van Loon, A.P. Mol. Cell. Biol. (1991) [Pubmed]
  35. Regulation of Ca2+ influx in myeloid cells. Role of plasma membrane potential, inositol phosphates, cytosolic free [Ca2+], and filling state of intracellular Ca2+ stores. Demaurex, N., Schlegel, W., Varnai, P., Mayr, G., Lew, D.P., Krause, K.H. J. Clin. Invest. (1992) [Pubmed]
  36. Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cells. Nervi, C., Grippo, J.F., Sherman, M.I., George, M.D., Jetten, A.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  37. Tumor necrosis factor inhibits MYC expression in HL-60 cells at the level of mRNA transcription. Krönke, M., Schlüter, C., Pfizenmaier, K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  38. Increased expression of p53 protein in human leukemia cells. Koeffler, H.P., Miller, C., Nicolson, M.A., Ranyard, J., Bosselman, R.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
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