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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Trinucleotide Repeats

 
 
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Disease relevance of Trinucleotide Repeats

 

Psychiatry related information on Trinucleotide Repeats

 

High impact information on Trinucleotide Repeats

 

Chemical compound and disease context of Trinucleotide Repeats

 

Biological context of Trinucleotide Repeats

 

Anatomical context of Trinucleotide Repeats

 

Associations of Trinucleotide Repeats with chemical compounds

  • Our results demonstrate the existence of the expanded CAG repeat gene product and support the possibility that the expanded CAG-encoded polyglutamine stretch may participate in the pathological process of the similar trinucleotide repeat diseases [31].
  • We now show that conclusive information about the chromosomal localization of long trinucleotide repeats can be achieved in a relatively short time using fluorescence in situ hybridization (FISH) with biotin-labelled trinucleotide polymers [32].
  • Ten individuals from different kindreds were found to have an identical polyalanine triplet repeat expansion ([GCG](9)) in the PABP2 gene [33].
  • The expansion of a polymorphic trinucleotide repeat (the sequence CAG that codes for glutamine) to a length that exceeds 40 repeat units in exon 1 of the gene, HD, correlates with the onset and progression of the disease [34].
  • The GCA hairpin loop consists of a single cytidine residue closed by a sheared G.A pair and this structure is discussed in the context of triplet expansions in triplet-repeat diseases [35].
 

Gene context of Trinucleotide Repeats

 

Analytical, diagnostic and therapeutic context of Trinucleotide Repeats

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