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MeSH Review

Goblet Cells

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Disease relevance of Goblet Cells


High impact information on Goblet Cells


Chemical compound and disease context of Goblet Cells


Biological context of Goblet Cells


Anatomical context of Goblet Cells

  • These data show that human colonic mucosa contains discrete subpopulations of goblet cells that produce distinctive combinations of specific mucin glycoprotein species [19].
  • CFTR expression was detected at the luminal surface of reabsorptive sweat ducts and airway submucosal glands, at the apex of ciliated cells in pseudostratified respiratory epithelia and of isolated cells of the villi of duodenum and jejunum, and within intracellular compartments of intestinal goblet cells [20].
  • RESULTS: In the normal small intestine and colon, an antibody recognizing the MUC2 apomucin stained goblet cells [21].
  • Polyclonal antibodies raised against purified human colonic mucin, and also a monoclonal antibody against a protease-sensitive epitope of human colonic mucin, stained secretory granules of all differentiated goblet cells within N2 cell monolayers but did not stain predifferentiated goblet cells lacking large secretory granules [22].
  • This was accompanied by morphological evidence of gland formation and mucin secretion and the appearance of discrete goblet cell and enterocyte populations [23].

Associations of Goblet Cells with chemical compounds


Gene context of Goblet Cells

  • This chronic switch in epithelial behavior exhibits genetic susceptibility and depends on persistent activation of EGFR signaling to PI3K that prevents apoptosis of ciliated cells and on IL-13 signaling that promotes transdifferentiation of ciliated to goblet cells [27].
  • Anti-MUC2 antibody was mainly reactive with intestinal goblet cells and cervical mucous cells [28].
  • The human MUC2 gene maps to chromosome 11p15, where three additional mucin genes have been located, and encodes the most abundant gastrointestinal mucin normally expressed in the intestinal goblet cell lineage [29].
  • MUC5AC is generally recognized to be a major airway mucin because MUC5AC is highly expressed in the goblet cells of human airway epithelium [30].
  • Thus, STAT6 activation mediates a transcriptional enhancement of TFF3 by induction of de novo synthesized protein in goblet cells [31].

Analytical, diagnostic and therapeutic context of Goblet Cells


  1. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. de Heer, H.J., Hammad, H., Soullié, T., Hijdra, D., Vos, N., Willart, M.A., Hoogsteden, H.C., Lambrecht, B.N. J. Exp. Med. (2004) [Pubmed]
  2. Regional distribution and alterations of lectin binding to colorectal mucin in mucosal biopsies from controls and subjects with inflammatory bowel diseases. Jacobs, L.R., Huber, P.W. J. Clin. Invest. (1985) [Pubmed]
  3. Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. Hanby, A.M., Poulsom, R., Singh, S., Elia, G., Jeffery, R.E., Wright, N.A. Gastroenterology (1993) [Pubmed]
  4. Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis. Dohi, T., Fujihashi, K., Kiyono, H., Elson, C.O., McGhee, J.R. Gastroenterology (2000) [Pubmed]
  5. Foxa2 regulates alveolarization and goblet cell hyperplasia. Wan, H., Kaestner, K.H., Ang, S.L., Ikegami, M., Finkelman, F.D., Stahlman, M.T., Fulkerson, P.C., Rothenberg, M.E., Whitsett, J.A. Development (2004) [Pubmed]
  6. Goblet cells in embryonic intestine: accelerated differentiation in culture. Black, B.L., Moog, F. Science (1977) [Pubmed]
  7. Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation. Shroyer, N.F., Wallis, D., Venken, K.J., Bellen, H.J., Zoghbi, H.Y. Genes Dev. (2005) [Pubmed]
  8. Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells. Zecchini, V., Domaschenz, R., Winton, D., Jones, P. Genes Dev. (2005) [Pubmed]
  9. The CF salt controversy: in vivo observations and therapeutic approaches. Tarran, R., Grubb, B.R., Parsons, D., Picher, M., Hirsh, A.J., Davis, C.W., Boucher, R.C. Mol. Cell (2001) [Pubmed]
  10. Mucus in chronic airway diseases: sorting out the sticky details. Cohn, L. J. Clin. Invest. (2006) [Pubmed]
  11. Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720. Sawicka, E., Zuany-Amorim, C., Manlius, C., Trifilieff, A., Brinkmann, V., Kemeny, D.M., Walker, C. J. Immunol. (2003) [Pubmed]
  12. Distribution of sialosyl Tn and Tn antigens within normal and malignant colorectal epithelium. Jass, J.R., Allison, L.J., Edgar, S.G. J. Pathol. (1995) [Pubmed]
  13. Allergen challenge causes inflammation but not goblet cell degranulation in asthmatic subjects. Hays, S.R., Woodruff, P.G., Khashayar, R., Ferrando, R.E., Liu, J., Fung, P., Zhao, C.Q., Wong, H.H., Fahy, J.V. J. Allergy Clin. Immunol. (2001) [Pubmed]
  14. Differential regulation by glucocorticoid of interleukin-13-induced eosinophilia, hyperresponsiveness, and goblet cell hyperplasia in mouse airways. Kibe, A., Inoue, H., Fukuyama, S., Machida, K., Matsumoto, K., Koto, H., Ikegami, T., Aizawa, H., Hara, N. Am. J. Respir. Crit. Care Med. (2003) [Pubmed]
  15. Inhibition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma. Hahn, C., Teufel, M., Herz, U., Renz, H., Erb, K.J., Wohlleben, G., Bröcker, E.B., Duschl, A., Sebald, W., Grunewald, S.M. J. Allergy Clin. Immunol. (2003) [Pubmed]
  16. A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells. Itoh, H., Beck, P.L., Inoue, N., Xavier, R., Podolsky, D.K. J. Clin. Invest. (1999) [Pubmed]
  17. Keratinocyte growth factor promotes goblet cell differentiation through regulation of goblet cell silencer inhibitor. Iwakiri, D., Podolsky, D.K. Gastroenterology (2001) [Pubmed]
  18. Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin. Ireland, H., Kemp, R., Houghton, C., Howard, L., Clarke, A.R., Sansom, O.J., Winton, D.J. Gastroenterology (2004) [Pubmed]
  19. Human colonic goblet cells. Demonstration of distinct subpopulations defined by mucin-specific monoclonal antibodies. Podolsky, D.K., Fournier, D.A., Lynch, K.E. J. Clin. Invest. (1986) [Pubmed]
  20. DeltaF508 CFTR protein expression in tissues from patients with cystic fibrosis. Kälin, N., Claass, A., Sommer, M., Puchelle, E., Tümmler, B. J. Clin. Invest. (1999) [Pubmed]
  21. Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. Chang, S.K., Dohrman, A.F., Basbaum, C.B., Ho, S.B., Tsuda, T., Toribara, N.W., Gum, J.R., Kim, Y.S. Gastroenterology (1994) [Pubmed]
  22. Human intestinal goblet cells in monolayer culture: characterization of a mucus-secreting subclone derived from the HT29 colon adenocarcinoma cell line. Phillips, T.E., Huet, C., Bilbo, P.R., Podolsky, D.K., Louvard, D., Neutra, M.R. Gastroenterology (1988) [Pubmed]
  23. Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation. Taupin, D., Podolsky, D.K. Gastroenterology (1999) [Pubmed]
  24. Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium. Klinger, J.D., Tandler, B., Liedtke, C.M., Boat, T.F. J. Clin. Invest. (1984) [Pubmed]
  25. Guanylin, an endogenous ligand for C-type guanylate cyclase, is produced by goblet cells in the rat intestine. Li, Z., Taylor-Blake, B., Light, A.R., Goy, M.F. Gastroenterology (1995) [Pubmed]
  26. Lectin binding patterns in developing rat colon. Colony, P.C., Steely, J. Gastroenterology (1987) [Pubmed]
  27. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. Tyner, J.W., Kim, E.Y., Ide, K., Pelletier, M.R., Roswit, W.T., Morton, J.D., Battaile, J.T., Patel, A.C., Patterson, G.A., Castro, M., Spoor, M.S., You, Y., Brody, S.L., Holtzman, M.J. J. Clin. Invest. (2006) [Pubmed]
  28. Differential apomucin expression in normal and neoplastic human gastrointestinal tissues. Carrato, C., Balague, C., de Bolos, C., Gonzalez, E., Gambus, G., Planas, J., Perini, J.M., Andreu, D., Real, F.X. Gastroenterology (1994) [Pubmed]
  29. Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus. Velcich, A., Palumbo, L., Selleri, L., Evans, G., Augenlicht, L. J. Biol. Chem. (1997) [Pubmed]
  30. Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. Song, K.S., Lee, W.J., Chung, K.C., Koo, J.S., Yang, E.J., Choi, J.Y., Yoon, J.H. J. Biol. Chem. (2003) [Pubmed]
  31. IL-4 and IL-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis. Blanchard, C., Durual, S., Estienne, M., Bouzakri, K., Heim, M.H., Blin, N., Cuber, J.C. J. Immunol. (2004) [Pubmed]
  32. Radioimmunoassay of human intestinal goblet cell mucin. Investigation of mucus from different organs and species. Qureshi, R., Forstner, G.G., Forstner, J.F. J. Clin. Invest. (1979) [Pubmed]
  33. Secretion of endogenous lectin by chicken intestinal goblet cells. Beyer, E.C., Barondes, S.H. J. Cell Biol. (1982) [Pubmed]
  34. A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats. Castagliuolo, I., Leeman, S.E., Bartolak-Suki, E., Nikulasson, S., Qiu, B., Carraway, R.E., Pothoulakis, C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  35. Development of a monoclonal antibody specifically reactive to gastrointestinal goblet cells. Vecchi, M., Sakamaki, S., Diamond, B., Novikoff, A.B., Novikoff, P.M., Das, K.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
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