Disease relevance of Vasculitis, Central Nervous System

• This study indicates that cardiac emboli from Libman-Sacks endocarditis and TTP are common pathogenetic factors of CNS disease in systemic lupus erythematosus, whereas CNS vasculitis is rare [1].
• A 20-year-old woman using an oral diet aid preparation containing phenylpropanolamine presented with an intracerebral hemorrhage and angiographic evidence of cerebral vasculitis [2].
• Herein we describe 6 patients with WG-related CNS involvement, 2 of whom had chronic hypertrophic pachymeningitis, 3 with pituitary involvement, and 1 with cerebral vasculitis [3].
• Three major mechanisms have been incriminated as causing CNS disease in WG: contiguous invasion of granuloma from extracranial sites, remote intracranial granuloma, and CNS vasculitis [3].
• Cerebral amyloid angiopathy and granulomatous angiitis: immunohistochemical study using antibodies to the Alzheimer A4 peptide [4].

High impact information on Vasculitis, Central Nervous System

• Cerebral vasculitis associated with cocaine abuse [5].
• Thus, various visual dysfunctions may occur in systemic lupus erythematosus due to cerebral vasculitis [6].
• METHODS: In 11 elderly patients with sporadic CAA, 2 patients with Icelandic familial CAA, and 2 patients with CAA and granulomatous angiitis, the cerebrovascular amyloid proteins and infiltrating inflammatory cells were analyzed immunohistochemically [7].
• This case illustrates potentially misleading early manifestations of isolated cerebral angiitis, diagnostic limitations of angiography, the value of biopsy that includes both brain parenchyma and leptomeninges, and the potential efficacy of steroid and cyclophosphamide therapy in small-vessel disease [8].
• A xenon Xe 133 cerebral blood flow study showed a global reduction in flow, compatible with CNS vasculitis [9].

Chemical compound and disease context of Vasculitis, Central Nervous System

• In a patient with angiographically proven cerebral vasculitis five months after acute posterior multifocal placoid pigment epitheliopathy (APMPPE) neurological symptoms promptly responded to steroid treatment [10].
• Progressive systemic sclerosis with CNS vasculitis and cyclosporin A therapy [11].
• Cerebral angiitis and intracerebral hemorrhage associated with methamphetamine abuse. Case report [12].
• Cerebral vasculitis stabilised by methotrexate [13].
• Focal cerebral vasculitis may be the pathogenesis of the Landau-Kleffner syndrome and calcium channel blockers such as nicardipine may be effective and specific therapy [14].

Anatomical context of Vasculitis, Central Nervous System

• Although CNS vasculitis does occur in some connective tissue diseases, it is rare in many others, including systemic lupus erythematosus [15].
• Cerebrospinal fluid neurofilament and glial fibrillary acidic protein in patients with cerebral vasculitis [16].
• The association of granulomatous angiitis and cerebral amyloid angiopathy constitutes a peculiar variety of central nervous system micro-angiopathy [17].
• Aetiologies were severe carotid artery disease in 14 cases, severe cardiopathy in 6, isolated cerebral angiitis in 1, essential thrombocythemia in 1, protein C deficiency with sickle cell disease in 1, and cholesterol emboli in 1 anatomical case [18].

Gene context of Vasculitis, Central Nervous System

• In the future, analysis of CSF NFL in particular, but also GFAP, may be a useful complement in the difficult clinical task of diagnosing CNS vasculitis [16].
• Cerebral vasculitis in rheumatoid arthritis [19].
• It is important for rheumatologists to consider MMD in the differential diagnosis of suspected CNS vasculitis [20].
• We hypothesized that the CNS vasculitis might be associated with the chronic B19 infection [21].
• Encephalopathy in compensated Hashimoto thyroiditis: a clinical expression of autoimmune cerebral vasculitis [22].

Analytical, diagnostic and therapeutic context of Vasculitis, Central Nervous System

• The purpose of the present retrospective study was to validate the use of the light subunit of neurofilament triplet protein (NFL) and glial fibrillary acidic protein (GFAP) as markers of CNS tissue damage for patients with systemic or isolated CNS vasculitis [16].
• Positron emission tomography in systemic lupus erythematosus: relation of cerebral vasculitis to PET findings [23].

References