Disease relevance of Veratrum

• Muscarinic acetylcholine receptors in neuroblastoma cells: lack of effect of Veratrum alkaloids on receptor number [1].
• Time course and inhibition of stavaroside K, veratramine and cevine-induced hemolysis by other pregnane glycosides and Veratrum alkaloids [2].

High impact information on Veratrum

• Synthetic studies in the veratrum alkaloid series. The total synthesis of C18-functionalized C-nor-D-homo steroid derivatives--valuable intermediates in the total synthesis of veratrum alkaloids [3].
• During use-dependent modification, the veratrum alkaloids reduced the total Na current markedly, while deltamethrin did not [4].
• The voltage-sensitive sodium channel is the major target site for DDT and pyrethroids, the veratrum alkaloids, and N-alkylamides [5].
• Myocardial responses to acetylstrophanthidin during veratrum alkaloid refractoriness [6].
• Inhibition of xanthine and monoamine oxidases by stilbenoids from Veratrum taliense [7].

Associations of Veratrum with chemical compounds

• Several of these reflex effects can also be elicited by other sensory stimulant agents such as phenyldiguanide, 5-hydroxytryptamine, and veratrum alkaloids [8].
• Hepatic microsomal formation of 3,4-dimethoxybenzoic acid and cumic acid from veratrum aldehyde and cuminaldehyde, respectively, was inhibited by CO and SKF 525-A [9].
• Norepinephrine levels were not modified in any brain region at any time after the administration of the veratrum alkaloid [10].
• Using the guinea-pig flank model which has been developed to study this cutaneous phenomenon we have constructed dose-response curves to three structurally related pyrethroids (permethrin, cypermethrin and deltamethrin) and to a mixture of veratrum alkaloids (veratrine) [11].
• The purpose of this study was to determine whether cardiac receptors that are stimulated by veratrum alkaloids exert an inhibitory influence on the secretion of vasopressin (ADH) [12].

References