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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Models, Animal

 
 
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Disease relevance of Models, Animal

 

Psychiatry related information on Models, Animal

 

High impact information on Models, Animal

 

Chemical compound and disease context of Models, Animal

 

Biological context of Models, Animal

 

Anatomical context of Models, Animal

 

Associations of Models, Animal with chemical compounds

  • In beta-cells, Glut-2 has been proposed to be active in the control of glucose-stimulated insulin secretion (GSIS; ref. 2), and its expression is strongly reduced in glucose-unresponsive islets from different animal models of diabetes [30].
  • These behavioral alterations are similar to those observed in pharmacologically induced animal models of schizophrenia and can be ameliorated by treatment with haloperidol or clozapine, antipsychotic drugs that antagonize dopaminergic and serotonergic receptors [31].
  • Beta carotene has been associated with a decreased risk of human cancer in many studies employing dietary questionnaires or blood measurements, and it has had protective effects in some animal models of carcinogenesis [32].
  • In an effort to produce selective, lateralized changes in brain dopamine metabolism associated with movement, we have now developed an animal model in which normal rats were trained to circle for a sucrose/water reward [33].
  • Muscle hyperexcitability was attributed to defects in sodium channels and/or to a decrease in chloride conductance (in Becker's myotonia and in genetic animal models) [34].
 

Gene context of Models, Animal

  • A naturally occurring animal model, the RPE65-/- dog, suffers from early and severe visual impairment similar to that seen in human LCA [35].
  • The expression pattern and chromosomal location of Sox9 suggest that it may be the gene defective in the mouse skeletal mutant Tail-short, a potential animal model for campomelic dysplasia [36].
  • Similar malformations are characteristic of individuals with Fraser syndrome and animal models of this human genetic disorder, such as mice carrying the blebbed mutation (bl) in the gene encoding the Fras1 ECM protein [13].
  • We found homozygous PHKG2 mutations in three human patients of consanguineous parentage and in the gsd (glycogen storage disease) rat strain, which is thus identified as an animal model for the human disorder [37].
  • We found that soluble versions of PLAD, especially those derived from P60, block the biochemical effects of TNF-alpha in vitro and potently inhibit arthritis in animal models [38].
 

Analytical, diagnostic and therapeutic context of Models, Animal

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