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MeSH Review


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Disease relevance of Thermogenesis


Psychiatry related information on Thermogenesis


High impact information on Thermogenesis

  • Facultative thermogenesis is activated by the SNS but is modulated by TH [11].
  • Both the acute activity of the tissue, i.e., the heat production, and the recruitment process in the tissue (that results in a higher thermogenic capacity) are under the control of norepinephrine released from sympathetic nerves [12].
  • The thermogenic activity of brown adipose tissue (BAT), important for adaptive thermogenesis and energy expenditure, is mediated by the mitochondrial uncoupling protein1 (Ucp1) that uncouples ATP generation and dissipates the energy as heat [1].
  • TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to reduced energy expenditure [13].
  • These results indicate that PGC-1 plays a key role in linking nuclear receptors to the transcriptional program of adaptive thermogenesis [14].

Chemical compound and disease context of Thermogenesis


Biological context of Thermogenesis


Anatomical context of Thermogenesis


Associations of Thermogenesis with chemical compounds


Gene context of Thermogenesis


Analytical, diagnostic and therapeutic context of Thermogenesis


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  2. Adiponectin acts in the brain to decrease body weight. Qi, Y., Takahashi, N., Hileman, S.M., Patel, H.R., Berg, A.H., Pajvani, U.B., Scherer, P.E., Ahima, R.S. Nat. Med. (2004) [Pubmed]
  3. Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis. Christoffolete, M.A., Linardi, C.C., de Jesus, L., Ebina, K.N., Carvalho, S.D., Ribeiro, M.O., Rabelo, R., Curcio, C., Martins, L., Kimura, E.T., Bianco, A.C. Diabetes (2004) [Pubmed]
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  15. Effects of sucrose vs starch diets on in vivo insulin action, thermogenesis, and obesity in rats. Storlien, L.H., Kraegen, E.W., Jenkins, A.B., Chisholm, D.J. Am. J. Clin. Nutr. (1988) [Pubmed]
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  17. Cooperation of a "reactive oxygen cycle" with the Q cycle and the proton cycle in the respiratory chain--superoxide generating and cycling mechanisms in mitochondria. Liu, S.S. J. Bioenerg. Biomembr. (1999) [Pubmed]
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  21. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Thomas, S.A., Palmiter, R.D. Nature (1997) [Pubmed]
  22. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Tsukiyama-Kohara, K., Poulin, F., Kohara, M., DeMaria, C.T., Cheng, A., Wu, Z., Gingras, A.C., Katsume, A., Elchebly, M., Spiegelman, B.M., Harper, M.E., Tremblay, M.L., Sonenberg, N. Nat. Med. (2001) [Pubmed]
  23. Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors. Golozoubova, V., Gullberg, H., Matthias, A., Cannon, B., Vennström, B., Nedergaard, J. Mol. Endocrinol. (2004) [Pubmed]
  24. Adrenergic activation of triiodothyronine production in brown adipose tissue. Silva, J.E., Larsen, P.R. Nature (1983) [Pubmed]
  25. Superoxide activates mitochondrial uncoupling proteins. Echtay, K.S., Roussel, D., St-Pierre, J., Jekabsons, M.B., Cadenas, S., Stuart, J.A., Harper, J.A., Roebuck, S.J., Morrison, A., Pickering, S., Clapham, J.C., Brand, M.D. Nature (2002) [Pubmed]
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  30. Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Zhang, Y., Castellani, L.W., Sinal, C.J., Gonzalez, F.J., Edwards, P.A. Genes Dev. (2004) [Pubmed]
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  34. Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. Millet, L., Vidal, H., Andreelli, F., Larrouy, D., Riou, J.P., Ricquier, D., Laville, M., Langin, D. J. Clin. Invest. (1997) [Pubmed]
  35. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. Argyropoulos, G., Brown, A.M., Willi, S.M., Zhu, J., He, Y., Reitman, M., Gevao, S.M., Spruill, I., Garvey, W.T. J. Clin. Invest. (1998) [Pubmed]
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  40. Overall myocardial energetics in physiological conditions and in acute volume overloading. Bui-Mong-Hung, n.u.l.l., Jarry, G., Maarek, J.M., Laurent, D. Eur. Heart J. (1984) [Pubmed]
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  42. Ascorbate distribution during hibernation is independent of ascorbate redox state. Ma, Y.L., Rice, M.E., Chao, M.L., Rivera, P.M., Zhao, H.W., Ross, A.P., Zhu, X., Smith, M.A., Drew, K.L. Free Radic. Biol. Med. (2004) [Pubmed]
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