The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Up-Regulation

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Up-Regulation

 

Psychiatry related information on Up-Regulation

 

High impact information on Up-Regulation

  • However, this upregulation in homeostatic regulatory mechanisms is not sufficient as these are unable to neutralize all the TNF alpha and IL-1 produced [11].
  • However, upregulation of Bcl-2 appears to be the normal mechanism for positive selection of developing lymphocytes, and its continued expression is critical for survival of mature peripheral B and T cells [12].
  • Measurements of leukotriene B4 (LTB4) production suggest that this risk is mediated through upregulation of the leukotriene pathway [13].
  • When neurons are stimulated by membrane depolarization, calcium signaling mediated by CaMKII induces dissociation of KIF4 from PARP-1, resulting in upregulation of PARP-1 activity, which supports neuron survival [14].
  • These studies provide evidence that environmental enrichment leads to reductions in steady-state levels of cerebral Abeta peptides and amyloid deposition and selective upregulation in levels of specific transcripts in brains of transgenic mice [15].
 

Chemical compound and disease context of Up-Regulation

 

Biological context of Up-Regulation

 

Anatomical context of Up-Regulation

 

Associations of Up-Regulation with chemical compounds

 

Gene context of Up-Regulation

  • Here we demonstrate that increased stability of Xist RNA is the primary determinant of developmental up-regulation [35].
  • Since aging increases promoter hypermethylation and epigenetic silencing of HIC1, we speculate that the resultant upregulation of SIRT1 may be a double-edged sword that both promotes survival of aging cells and increases cancer risk in mammals [36].
  • The upregulation of TGF-beta1 and integrin expression during wound healing has implicated these molecules in this process, but their precise regulation and roles remain unclear [37].
  • Here we show that oxidized phospholipids inhibit LPS-induced but not tumour-necrosis factor-alpha-induced or interleukin-1 beta-induced NF kappa B-mediated upregulation of inflammatory genes, by blocking the interaction of LPS with LPS-binding protein and CD14 [38].
  • Our results bring strong support to the hypothesis that muscle wasting in dystrophin-deficient DMD patients could be prevented by upregulation of utrophin [39].
 

Analytical, diagnostic and therapeutic context of Up-Regulation

References

  1. A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers. Tsuge, M., Hamamoto, R., Silva, F.P., Ohnishi, Y., Chayama, K., Kamatani, N., Furukawa, Y., Nakamura, Y. Nat. Genet. (2005) [Pubmed]
  2. Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. Turner, C.A., Mack, D.H., Davis, M.M. Cell (1994) [Pubmed]
  3. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. Coucke, P.J., Willaert, A., Wessels, M.W., Callewaert, B., Zoppi, N., De Backer, J., Fox, J.E., Mancini, G.M., Kambouris, M., Gardella, R., Facchetti, F., Willems, P.J., Forsyth, R., Dietz, H.C., Barlati, S., Colombi, M., Loeys, B., De Paepe, A. Nat. Genet. (2006) [Pubmed]
  4. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Côté, F., Collard, J.F., Julien, J.P. Cell (1993) [Pubmed]
  5. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Westendorp, M.O., Frank, R., Ochsenbauer, C., Stricker, K., Dhein, J., Walczak, H., Debatin, K.M., Krammer, P.H. Nature (1995) [Pubmed]
  6. An ATP-driven efflux pump is a novel pathogenicity factor in rice blast disease. Urban, M., Bhargava, T., Hamer, J.E. EMBO J. (1999) [Pubmed]
  7. Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease. Nishiyama, K., Trapp, B.D., Ikezu, T., Ransohoff, R.M., Tomita, T., Iwatsubo, T., Kanazawa, I., Hsiao, K.K., Lisanti, M.P., Okamoto, T. J. Neurosci. (1999) [Pubmed]
  8. Overexpression of dynamin is induced by chronic stimulation of mu- but not delta-opioid receptors: relationships with mu-related morphine dependence. Noble, F., Szücs, M., Kieffer, B., Roques, B.P. Mol. Pharmacol. (2000) [Pubmed]
  9. Dopamine-receptor autoradiography of human narcoleptic brain. Aldrich, M.S., Hollingsworth, Z., Penney, J.B. Neurology (1992) [Pubmed]
  10. Preferential feline immunodeficiency virus (FIV) infection of CD4+ CD25+ T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors. Joshi, A., Garg, H., Tompkins, M.B., Tompkins, W.A. J. Virol. (2005) [Pubmed]
  11. Role of cytokines in rheumatoid arthritis. Feldmann, M., Brennan, F.M., Maini, R.N. Annu. Rev. Immunol. (1996) [Pubmed]
  12. Regulation of lymphocyte survival by the bcl-2 gene family. Cory, S. Annu. Rev. Immunol. (1995) [Pubmed]
  13. A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Helgadottir, A., Manolescu, A., Helgason, A., Thorleifsson, G., Thorsteinsdottir, U., Gudbjartsson, D.F., Gretarsdottir, S., Magnusson, K.P., Gudmundsson, G., Hicks, A., Jonsson, T., Grant, S.F., Sainz, J., O'Brien, S.J., Sveinbjornsdottir, S., Valdimarsson, E.M., Matthiasson, S.E., Levey, A.I., Abramson, J.L., Reilly, M.P., Vaccarino, V., Wolfe, M.L., Gudnason, V., Quyyumi, A.A., Topol, E.J., Rader, D.J., Thorgeirsson, G., Gulcher, J.R., Hakonarson, H., Kong, A., Stefansson, K. Nat. Genet. (2006) [Pubmed]
  14. KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity. Midorikawa, R., Takei, Y., Hirokawa, N. Cell (2006) [Pubmed]
  15. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Lazarov, O., Robinson, J., Tang, Y.P., Hairston, I.S., Korade-Mirnics, Z., Lee, V.M., Hersh, L.B., Sapolsky, R.M., Mirnics, K., Sisodia, S.S. Cell (2005) [Pubmed]
  16. Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion. Morigi, M., Angioletti, S., Imberti, B., Donadelli, R., Micheletti, G., Figliuzzi, M., Remuzzi, A., Zoja, C., Remuzzi, G. J. Clin. Invest. (1998) [Pubmed]
  17. Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis. Arnon, R., Yoshimura, T., Reiss, A., Budai, K., Lefkowitch, J.H., Javitt, N.B. Gastroenterology (1998) [Pubmed]
  18. Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis. Janes, S.M., Watt, F.M. J. Cell Biol. (2004) [Pubmed]
  19. Angiotensin II-induced hypertension increases heme oxygenase-1 expression in rat aorta. Ishizaka, N., de León, H., Laursen, J.B., Fukui, T., Wilcox, J.N., De Keulenaer, G., Griendling, K.K., Alexander, R.W. Circulation (1997) [Pubmed]
  20. Poxvirus-induced alteration of arachidonate metabolism. Palumbo, G.J., Glasgow, W.C., Buller, R.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  21. Ras1 promotes cellular growth in the Drosophila wing. Prober, D.A., Edgar, B.A. Cell (2000) [Pubmed]
  22. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Blasco, M.A., Rizen, M., Greider, C.W., Hanahan, D. Nat. Genet. (1996) [Pubmed]
  23. Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Rudnicki, M.A., Braun, T., Hinuma, S., Jaenisch, R. Cell (1992) [Pubmed]
  24. Targeted mutagenesis of Tsix leads to nonrandom X inactivation. Lee, J.T., Lu, N. Cell (1999) [Pubmed]
  25. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. Newport, M.J., Huxley, C.M., Huston, S., Hawrylowicz, C.M., Oostra, B.A., Williamson, R., Levin, M. N. Engl. J. Med. (1996) [Pubmed]
  26. Dominant effector genetics in mammalian cells. Xu, X., Leo, C., Jang, Y., Chan, E., Padilla, D., Huang, B.C., Lin, T., Gururaja, T., Hitoshi, Y., Lorens, J.B., Anderson, D.C., Sikic, B., Luo, Y., Payan, D.G., Nolan, G.P. Nat. Genet. (2001) [Pubmed]
  27. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Cheng, T., Liu, D., Griffin, J.H., Fernández, J.A., Castellino, F., Rosen, E.D., Fukudome, K., Zlokovic, B.V. Nat. Med. (2003) [Pubmed]
  28. Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents. St Croix, B., Flørenes, V.A., Rak, J.W., Flanagan, M., Bhattacharya, N., Slingerland, J.M., Kerbel, R.S. Nat. Med. (1996) [Pubmed]
  29. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Youssef, S., Stüve, O., Patarroyo, J.C., Ruiz, P.J., Radosevich, J.L., Hur, E.M., Bravo, M., Mitchell, D.J., Sobel, R.A., Steinman, L., Zamvil, S.S. Nature (2002) [Pubmed]
  30. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Koyama, H., Raines, E.W., Bornfeldt, K.E., Roberts, J.M., Ross, R. Cell (1996) [Pubmed]
  31. Sir2 blocks extreme life-span extension. Fabrizio, P., Gattazzo, C., Battistella, L., Wei, M., Cheng, C., McGrew, K., Longo, V.D. Cell (2005) [Pubmed]
  32. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Burke, R., Nellen, D., Bellotto, M., Hafen, E., Senti, K.A., Dickson, B.J., Basler, K. Cell (1999) [Pubmed]
  33. Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. Lotan, R., Xu, X.C., Lippman, S.M., Ro, J.Y., Lee, J.S., Lee, J.J., Hong, W.K. N. Engl. J. Med. (1995) [Pubmed]
  34. Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli. Springall, T., Sheerin, N.S., Abe, K., Holers, V.M., Wan, H., Sacks, S.H. Nat. Med. (2001) [Pubmed]
  35. Stabilization of Xist RNA mediates initiation of X chromosome inactivation. Sheardown, S.A., Duthie, S.M., Johnston, C.M., Newall, A.E., Formstone, E.J., Arkell, R.M., Nesterova, T.B., Alghisi, G.C., Rastan, S., Brockdorff, N. Cell (1997) [Pubmed]
  36. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Chen, W.Y., Wang, D.H., Yen, R.C., Luo, J., Gu, W., Baylin, S.B. Cell (2005) [Pubmed]
  37. Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Reynolds, L.E., Conti, F.J., Lucas, M., Grose, R., Robinson, S., Stone, M., Saunders, G., Dickson, C., Hynes, R.O., Lacy-Hulbert, A., Hodivala-Dilke, K. Nat. Med. (2005) [Pubmed]
  38. Protective role of phospholipid oxidation products in endotoxin-induced tissue damage. Bochkov, V.N., Kadl, A., Huber, J., Gruber, F., Binder, B.R., Leitinger, N. Nature (2002) [Pubmed]
  39. Expression of truncated utrophin leads to major functional improvements in dystrophin-deficient muscles of mice. Deconinck, N., Tinsley, J., De Backer, F., Fisher, R., Kahn, D., Phelps, S., Davies, K., Gillis, J.M. Nat. Med. (1997) [Pubmed]
  40. Association between kinin B(1) receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules. McLean, P.G., Ahluwalia, A., Perretti, M. J. Exp. Med. (2000) [Pubmed]
  41. Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway. van der Voort, R., Taher, T.E., Keehnen, R.M., Smit, L., Groenink, M., Pals, S.T. J. Exp. Med. (1997) [Pubmed]
  42. Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype. Jabbari, A., Harty, J.T. J. Exp. Med. (2006) [Pubmed]
  43. Dihydropyridine receptor gene expression is regulated by inhibitors of myogenesis and is relatively insensitive to denervation. Shih, H.T., Wathen, M.S., Marshall, H.B., Caffrey, J.M., Schneider, M.D. J. Clin. Invest. (1990) [Pubmed]
  44. Human/severe combined immunodeficient mouse chimeras. An experimental in vivo model system to study the regulation of human endothelial cell-leukocyte adhesion molecules. Yan, H.C., Juhasz, I., Pilewski, J., Murphy, G.F., Herlyn, M., Albelda, S.M. J. Clin. Invest. (1993) [Pubmed]
 
WikiGenes - Universities