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MeSH Review

Kirsten murine sarcoma virus

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Disease relevance of Kirsten murine sarcoma virus


High impact information on Kirsten murine sarcoma virus


Chemical compound and disease context of Kirsten murine sarcoma virus


Biological context of Kirsten murine sarcoma virus


Anatomical context of Kirsten murine sarcoma virus

  • MEP proteins synthesized by normal NIH 3T3 cells or NIH cells transformed with Kirsten sarcoma virus displayed a similar low affinity for the receptor and were found to possess oligosaccharide species with two phosphomonoester moieties [18].
  • Subsequent infection of these cells with Kirsten murine sarcoma virus containing an activated Ki-ras oncogene induces at least a 10-20-fold increase in PTHRP expression and production of both adult and fetal immortalized cell lines in the presence of the same growth factors [19].
  • In this report, we show that when human osteosarcoma derived clonal cells (TE 85 clone F-5) (HOS), which are immortalized and nontumorigenic, undergo transformation following infection by Kirsten murine sarcoma virus (K-HOS) or by a chemical carcinogen [N-methyl-N-nitro-N-nitrosoguanidine (MNNG-HOS)], the smooth muscle MLC-2 mRNA is repressed [20].

Gene context of Kirsten murine sarcoma virus


  1. Kirsten murine sarcoma virus abolishes interferon gamma-induced class II but not class I major histocompatibility antigen expression in a murine fibroblast line. Maudsley, D.J., Morris, A.G. J. Exp. Med. (1988) [Pubmed]
  2. A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Guerrero, I., Calzada, P., Mayer, A., Pellicer, A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  3. Accelerated malignant conversion of human HBL-100 cells by the v-Ki-ras oncogene. Saint-Ruf, C., Nardeux, P., Estrade, S., Brouty-Boye, D., Lavialle, C., Rhim, J.S., Cassingena, R. Exp. Cell Res. (1988) [Pubmed]
  4. Characterization of human cells transformed in vitro by N-methyl-N'-nitro-N-nitrosoguanidine. Rhim, J.S., Putman, D.L., Arnstein, P., Huebner, R.J., McAllister, R.M. Int. J. Cancer (1977) [Pubmed]
  5. Loss of epidermal growth factor receptor on the renal neoplasm induced in vivo with Xenotropic pseudotype Kirsten murine sarcoma virus. Usui, T., Moriyama, N., Ishibe, T., Nakatsu, H. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  6. Harvey and Kirsten sarcoma viruses promote the growth and differentiation of erythroid precursor cells in vitro. Hankins, W.D., Scolnick, E.M. Cell (1981) [Pubmed]
  7. Tumor promoters and Kirsten sarcoma virus increase synthesis of a secreted glycoprotein by regulating levels of translatable mRNA. Gottesman, M.M., Sobel, M.E. Cell (1980) [Pubmed]
  8. Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses. Rhim, J.S., Jay, G., Arnstein, P., Price, F.M., Sanford, K.K., Aaronson, S.A. Science (1985) [Pubmed]
  9. Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus. Tsuchida, N., Ohtsubo, E., Ryder, T. Science (1982) [Pubmed]
  10. Reversible inhibition of a thyroid-specific trans-acting factor by Ras. Avvedimento, V.E., Musti, A.M., Ueffing, M., Obici, S., Gallo, A., Sanchez, M., DeBrasi, D., Gottesman, M.E. Genes Dev. (1991) [Pubmed]
  11. An unusual oxygen-sensitive lactate dehydrogenase isozyme associated with Kirsten murine sarcoma virus in human serum. Polonis, V.R., Anderson, G.R., Brzykcy, J., Vladutiu, A.O., Manly, K.F. Cancer Res. (1984) [Pubmed]
  12. Enhanced G2 chromatid radiosensitivity, an early stage in the neoplastic transformation of human epidermal keratinocytes in culture. Gantt, R., Sanford, K.K., Parshad, R., Price, F.M., Peterson, W.D., Rhim, J.S. Cancer Res. (1987) [Pubmed]
  13. Thyroid hormone modulation of transformation induced by Kirsten murine sarcoma virus. Borek, C., Ong, A., Rhim, J.S. Cancer Res. (1985) [Pubmed]
  14. Correlation between the rates of aerobic glycolysis and glucose transport, unrelated to neoplastic transformation, in a series of BALB 3T3-derived cell lines. Peterkofsky, B., Prather, W. Cancer Res. (1982) [Pubmed]
  15. Adhesion of Kirsten-ras+ tumor-progressing and Kirsten-ras- revertant 3T3 cells on fibronectin proteolytic fragments. Radinsky, R., Flickinger, K.S., Kosir, M.A., Zardi, L., Culp, L.A. Cancer Res. (1990) [Pubmed]
  16. Characterizatiion of rat genetic sequences of Kirsten sarcoma virus: distinct class of endogenous rat type C viral sequences. Scolnick, E.M., Goldberg, R.J., Williams, D. J. Virol. (1976) [Pubmed]
  17. Activation of the proto-oncogene c-myc and c-fos by c-ras: involvement of polyamines. Tabib, A., Bachrach, U. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  18. Basis for low affinity binding of a lysosomal cysteine protease to the cation-independent mannose 6-phosphate receptor. Dong, J.M., Sahagian, G.G. J. Biol. Chem. (1990) [Pubmed]
  19. ras Activation of human prostate epithelial cells induces overexpression of parathyroid hormone-related peptide. Kremer, R., Goltzman, D., Amizuka, N., Webber, M.M., Rhim, J.S. Clin. Cancer Res. (1997) [Pubmed]
  20. Human smooth muscle myosin light chain-2 gene expression is repressed in ras transformed fibroblast cells. Kumar, C.C., Chang, C. Cell Growth Differ. (1992) [Pubmed]
  21. Isolation and characterization of Kirsten murine sarcoma virus-transformed mouse keratinocytes resistant to transforming growth factor beta. Sipes, N.J., Lyons, R.M., Moses, H.L. Mol. Carcinog. (1990) [Pubmed]
  22. Nonfunctional epidermal growth factor receptor in cells transformed by Kirsten sarcoma virus. Chua, C.C., Geiman, D.E., Schreiber, A.B., Ladda, R.L. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  23. Synthesis and secretion of plasminogen activators and collagenases in human cells transformed by Kirsten murine sarcoma virus and N-methyl-N'-nitro-N-nitrosoguanidine. Sidhu, M.K., Kumar, S. Cancer Lett. (1989) [Pubmed]
  24. The tumor promoter phorbol 12-myristate 13-acetate induces a program of altered gene expression similar to that induced by platelet-derived growth factor and transforming oncogenes. Rabin, M.S., Doherty, P.J., Gottesman, M.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
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