The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lithospermum


High impact information on Lithospermum


Biological context of Lithospermum


Anatomical context of Lithospermum


Associations of Lithospermum with chemical compounds


Gene context of Lithospermum


Analytical, diagnostic and therapeutic context of Lithospermum


  1. Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1. Chen, X., Yang, L., Zhang, N., Turpin, J.A., Buckheit, R.W., Osterling, C., Oppenheim, J.J., Howard, O.M. Antimicrob. Agents Chemother. (2003) [Pubmed]
  2. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. Masuda, Y., Shima, G., Aiuchi, T., Horie, M., Hori, K., Nakajo, S., Kajimoto, S., Shibayama-Imazu, T., Nakaya, K. J. Biol. Chem. (2004) [Pubmed]
  3. Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. Staniforth, V., Wang, S.Y., Shyur, L.F., Yang, N.S. J. Biol. Chem. (2004) [Pubmed]
  4. Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis. Yazaki, K., Kunihisa, M., Fujisaki, T., Sato, F. J. Biol. Chem. (2002) [Pubmed]
  5. Nucleotide sequence of a cDNA from Lithospermum erythrorhizon homologous to PR-1 of parsley. Yazaki, K., Bechthold, A., Tabata, M. Plant Physiol. (1995) [Pubmed]
  6. CYP98A6 from Lithospermum erythrorhizon encodes 4-coumaroyl-4'-hydroxyphenyllactic acid 3-hydroxylase involved in rosmarinic acid biosynthesis. Matsuno, M., Nagatsu, A., Ogihara, Y., Ellis, B.E., Mizukami, H. FEBS Lett. (2002) [Pubmed]
  7. Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene. Sommer, S., Köhle, A., Yazaki, K., Shimomura, K., Bechthold, A., Heide, L. Plant Mol. Biol. (1999) [Pubmed]
  8. Immunomodulatory effect of shikonin derivatives isolated from Lithospermum canescens on cellular and humoral immunity in Balb/c mice. Pietrosiuk, A., Skopińska-Rózewska, E., Furmanowa, M., Wiedenfeld, H., Sommer, E., Sokolnicka, I., Rogala, E., Radomska-Leśniewska, D., Bany, J., Malinowski, M. Die Pharmazie. (2004) [Pubmed]
  9. Shikonin, an ingredient of Lithospermum erythrorhizon induced apoptosis in HL60 human premyelocytic leukemia cell line. Yoon, Y., Kim, Y.O., Lim, N.Y., Jeon, W.K., Sung, H.J. Planta Med. (1999) [Pubmed]
  10. Antihormonal effects of plant extracts. Pharmacodynamic effects of lithospermum officinale on the thyroid gland of rats; comparison with the effects of iodide. Winterhoff, H., Sourgens, H., Kemper, F.H. Horm. Metab. Res. (1983) [Pubmed]
  11. Effects of Chinese herbs on macrophage functions in N-butyl-N-butanolnitrosoamine treated mice. Jin, R., Kurashige, S. Immunopharmacology and immunotoxicology. (1996) [Pubmed]
  12. Inhibition of lipopolysaccharide and interferon-gamma-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by Lithospermi radix in mouse peritoneal macrophages. Chung, H.S., Kang, M., Cho, C., Park, S., Kim, H., Yoon, Y.S., Kang, J., Shin, M.K., Hong, M.C., Bae, H. Journal of ethnopharmacology. (2005) [Pubmed]
  13. 4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon: purification of a plant membrane-bound prenyltransferase. Mühlenweg, A., Melzer, M., Li, S.M., Heide, L. Planta (1998) [Pubmed]
  14. Geranylhydroquinone 3"-hydroxylase, a cytochrome P-450 monooxygenase from Lithospermum erythrorhizon cell suspension cultures. Yamamoto, H., Inoue, K., Li, S.M., Heide, L. Planta (2000) [Pubmed]
  15. Caffeic acid metabolites from Eritrichium sericeum cell cultures. Fedoreyev, S.A., Veselova, M.V., Krivoschekova, O.E., Mischenko, N.P., Denisenko, V.A., Dmitrenok, P.S., Glazunov, V.P., Bulgakov, V.P., Tchernoded, G.K., Zhuravlev, Y.N. Planta Med. (2005) [Pubmed]
  16. Partial purification and properties of geranyl pyrophosphate synthase from Lithospermum erythrorhizon cell cultures. Heide, L., Berger, U. Arch. Biochem. Biophys. (1989) [Pubmed]
  17. Genetic engineering on shikonin biosynthesis: expression of the bacterial ubiA gene in Lithospermum erythrorhizon. Boehm, R., Sommer, S., Li, S.M., Heide, L. Plant Cell Physiol. (2000) [Pubmed]
  18. Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I. Ahn, B.Z., Baik, K.U., Kweon, G.R., Lim, K., Hwang, B.D. J. Med. Chem. (1995) [Pubmed]
  19. Regulatory role of microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase for shikonin biosynthesis in Lithospermum erythrorhizon cell suspension cultures. Lange, B.M., Severin, K., Bechthold, A., Heide, L. Planta (1998) [Pubmed]
  20. 4-Coumaroyl coenzyme A 3-hydroxylase activity from cell cultures of Lithospermum erythrorhizon and its relationship to polyphenol oxidase. Wang, Z.X., Li, S.M., Löscher, R., Heide, L. Arch. Biochem. Biophys. (1997) [Pubmed]
  21. Molecular cloning and characterization of a cDNA encoding a novel apoplastic protein preferentially expressed in a shikonin-producing callus strain of Lithospermum erythrorhizon. Yamamura, Y., Sahin, F.P., Nagatsu, A., Mizukami, H. Plant Cell Physiol. (2003) [Pubmed]
  22. Simultaneous analysis of shikimate-derived secondary metabolites in Lithospermum erythrorhizon cell suspension cultures by high-performance liquid chromatography. Yamamoto, H., Yazaki, K., Inoue, K. J. Chromatogr. B Biomed. Sci. Appl. (2000) [Pubmed]
  23. Enantiomeric ratio of shikonin derivatives as a possible key for the determination of the origin of lithospermi radix. Kang, J.S., Ahn, B.Z., Blaschke, G. Arch. Pharm. Res. (1998) [Pubmed]
WikiGenes - Universities