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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Azadirachta

 
 
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Disease relevance of Azadirachta

  • Thirty days post-infection the lambs were treated orally with a single dosage of one of the following products: group A with 3 mg/kg body weight (BW) of an aqueous ethanol extract (70%, v/v) of the seeds of Azadirachta indica A [1].
 

High impact information on Azadirachta

  • The purpose of this investigation was to examine the inhibitory effects of aqueous extracts derived from the bark-containing sticks (Neem stick) of Azadirachta indica upon bacterial aggregation, growth, adhesion to hydroxyapatite, and production of insoluble glucan, which may affect in vitro plaque formation [2].
  • This paper presents experimental results on the successful encapsulation of a natural liquid pesticide 'neem (Azadirachta Indica A. Juss.) seed oil' hereafter designated as NSO, using sodium alginate (Na-Alg) as a controlled release (CR) polymer after crosslinking with glutaraldehyde (GA) [3].
  • The antiulcer effect of aqueous extracts of the leaves of the neem tree was investigated in rats exposed to 2-h cold-restraint stress or given ethanol orally for 1 h [4].
  • Three new azadirachtin derivatives, named azadirachtins O-Q (1-3), along with the known azadirachtin B (4), azadirachtin L (5), azadirachtin M (6) 11alpha-azadirachtin H (7), 11beta-azadirachtin H (8), and azadirachtol (9) were isolated from seed kernels of Azadirachta excelsa [5].
  • Direct differentiation of somatic embryos on different regions of intact seedlings of Azadirachta in response to thidiazuron [6].
 

Chemical compound and disease context of Azadirachta

 

Biological context of Azadirachta

 

Associations of Azadirachta with chemical compounds

  • Performance of broiler chicks fed on diets containing urea ammoniated neem (Azadirachta indica) kernel cake [11].
  • The main plants used were Azadirachta indica and Curcuma longa [12].
  • Gastroprotective effect of Neem (Azadirachta indica) bark extract: possible involvement of H(+)-K(+)-ATPase inhibition and scavenging of hydroxyl radical [13].
  • Mahmoodin [1], a new limonoid, has been isolated from Azadirachta indica (neem) oil, along with seven known tetranortriterpenoids, azadirone, epoxyazadiradione, nimbin, gedunin, azadiradione, deacetylnimbin, and 17-hydroxyazadiradione [14].
  • Constituents of Azadirachta indica: isolation and structure elucidation of a new antibacterial tetranortriterpenoid, mahmoodin, and a new protolimonoid, naheedin [14].
 

Gene context of Azadirachta

 

Analytical, diagnostic and therapeutic context of Azadirachta

References

  1. The anthelmintic efficacy of five plant products against gastrointestinal trichostrongylids in artificially infected lambs. Hördegen, P., Hertzberg, H., Heilmann, J., Langhans, W., Maurer, V. Vet. Parasitol. (2003) [Pubmed]
  2. The inhibiting effect of aqueous Azadirachta indica (Neem) extract upon bacterial properties influencing in vitro plaque formation. Wolinsky, L.E., Mania, S., Nachnani, S., Ling, S. J. Dent. Res. (1996) [Pubmed]
  3. Glutaraldehyde crosslinked sodium alginate beads containing liquid pesticide for soil application. Kulkarni, A.R., Soppimath, K.S., Aminabhavi, T.M., Dave, A.M., Mehta, M.H. Journal of controlled release : official journal of the Controlled Release Society. (2000) [Pubmed]
  4. The gastric antiulcer effects of the leaves of the neem tree. Garg, G.P., Nigam, S.K., Ogle, C.W. Planta Med. (1993) [Pubmed]
  5. Azadirachtin derivatives from seed kernels of Azadirachta excelsa. Kanokmedhakul, S., Kanokmedhakul, K., Prajuabsuk, T., Panichajakul, S., Panyamee, P., Prabpai, S., Kongsaeree, P. J. Nat. Prod. (2005) [Pubmed]
  6. Direct differentiation of somatic embryos on different regions of intact seedlings of Azadirachta in response to thidiazuron. Gairi, A., Rashid, A. J. Plant Physiol. (2004) [Pubmed]
  7. Ultrastructural changes in Leydig cells and cauda epididymal spermatozoa induced by Azadirachta indica leaves in albino rats. Aladakatti, R.H., Ahamed, R.N. Phytotherapy research : PTR. (2005) [Pubmed]
  8. Studies on the contraceptive efficacy of Praneem polyherbal cream. Garg, S., Taluja, V., Upadhyay, S.N., Talwar, G.P. Contraception. (1993) [Pubmed]
  9. Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats. Gupta, S., Kataria, M., Gupta, P.K., Murganandan, S., Yashroy, R.C. Journal of ethnopharmacology. (2004) [Pubmed]
  10. Effect of Azadirachta indica on paracetamol-induced hepatic damage in albino rats. Yanpallewar, S.U., Sen, S., Tapas, S., Kumar, M., Raju, S.S., Acharya, S.B. Phytomedicine (2003) [Pubmed]
  11. Performance of broiler chicks fed on diets containing urea ammoniated neem (Azadirachta indica) kernel cake. Nagalakshmi, D., Sastry, V.R., Katiyar, R.C., Agrawal, D.K., Verma, S.V. Br. Poult. Sci. (1999) [Pubmed]
  12. Ethnoveterinary medicines used for ruminants in Trinidad and Tobago. Lans, C., Brown, G. Prev. Vet. Med. (1998) [Pubmed]
  13. Gastroprotective effect of Neem (Azadirachta indica) bark extract: possible involvement of H(+)-K(+)-ATPase inhibition and scavenging of hydroxyl radical. Bandyopadhyay, U., Biswas, K., Chatterjee, R., Bandyopadhyay, D., Chattopadhyay, I., Ganguly, C.K., Chakraborty, T., Bhattacharya, K., Banerjee, R.K. Life Sci. (2002) [Pubmed]
  14. Constituents of Azadirachta indica: isolation and structure elucidation of a new antibacterial tetranortriterpenoid, mahmoodin, and a new protolimonoid, naheedin. Siddiqui, S., Faizi, S., Siddiqui, B.S., Ghiasuddin, n.u.l.l. J. Nat. Prod. (1992) [Pubmed]
  15. Isolation of antioxidant principle from Azadirachta seed kernels: determination of its role on plant lipoxygenases. Rao, A.D., Devi, K.N., Thyagaraju, K. J. Enzym. Inhib. (1998) [Pubmed]
  16. Effects of the neem tree compounds azadirachtin, salannin, nimbin, and 6-desacetylnimbin on ecdysone 20-monooxygenase activity. Mitchell, M.J., Smith, S.L., Johnson, S., Morgan, E.D. Arch. Insect Biochem. Physiol. (1997) [Pubmed]
  17. Effects of Vepacide (Azadirachta indica) on aspartate and alanine aminotransferase profiles in a subchronic study with rats. Rahman, M.F., Siddiqui, M.K., Jamil, K. Human & experimental toxicology. (2001) [Pubmed]
  18. Quinone reductase inducers in Azadirachta indica A. Juss flowers, and their mechanisms of action. Sritanaudomchai, H., Kusamran, T., Kuakulkiat, W., Bunyapraphatsara, N., Hiransalee, A., Tepsuwan, A., Kusamran, W.R. Asian Pac. J. Cancer Prev. (2005) [Pubmed]
  19. The effect of Azadirachta indica on distribution of antioxidant elements and glutathione S-transferase activity in the liver of rats during hepatocarcinogenesis. Hanachi, P., Fauziah, O., Peng, L.T., Wei, L.C., Nam, L.L., Tian, T.S. Asia Pacific journal of clinical nutrition. (2004) [Pubmed]
 
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