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MeSH Review

Polymorphism, Restriction Fragment Length

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Disease relevance of Polymorphism, Restriction Fragment Length


Psychiatry related information on Polymorphism, Restriction Fragment Length


High impact information on Polymorphism, Restriction Fragment Length


Chemical compound and disease context of Polymorphism, Restriction Fragment Length


Biological context of Polymorphism, Restriction Fragment Length


Anatomical context of Polymorphism, Restriction Fragment Length


Associations of Polymorphism, Restriction Fragment Length with chemical compounds

  • A case was defined as tuberculosis in a patient with an isolate resistant to isoniazid, rifampin, ethambutol hydrochloride, and streptomycin (and rifabutin, if sensitivity testing included it), and, if RFLP testing was done, a pattern identical to or closely related to strain W [31].
  • Class II probes (A-alpha in particular) distinguish four restriction fragment length polymorphisms (RFLP), termed 1a, 1b, 2a, and 2b, in the BBN population, only one of which (2a) is found in BB rats [32].
  • In addition, by polymerase chain reaction amplification and sequencing of 740 bp of the 5' part of TNF-beta of individuals typed homozygously for the NcoI RFLP, we could show that amino acid position 26 is conserved as asparagine in the TNFB*1 and as threonine in the TNFB*2 sequence [33].
  • Isolation of a complementary DNA clone for the human complement protein C2 and its use in the identification of a restriction fragment length polymorphism [34].
  • First, we sequentially used the Factor IX probes (sequentially with restriction enzymes Taq I, Xmn I, and Dde I), and the linked probes p45h (Taq I), p45d (Pst I), and 52a (Taq I) for restriction fragment length polymorphism (RFLP) analysis [35].

Gene context of Polymorphism, Restriction Fragment Length


Analytical, diagnostic and therapeutic context of Polymorphism, Restriction Fragment Length


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  16. Relation of a TNF gene polymorphism to severe sepsis in trauma patients. Majetschak, M., Flohé, S., Obertacke, U., Schröder, J., Staubach, K., Nast-Kolb, D., Schade, F.U., Stüber, F. Ann. Surg. (1999) [Pubmed]
  17. High prevalence of KatG Ser315Thr substitution among isoniazid-resistant Mycobacterium tuberculosis clinical isolates from northwestern Russia, 1996 to 2001. Mokrousov, I., Narvskaya, O., Otten, T., Limeschenko, E., Steklova, L., Vyshnevskiy, B. Antimicrob. Agents Chemother. (2002) [Pubmed]
  18. Cytomegalovirus glycoprotein B genotyping in ocular fluids and blood of AIDS patients with cytomegalovirus retinitis. Peek, R., Verbraak, F., Bruinenberg, M., Van der Lelij, A., Van den Horn, G., Kijlstra, A. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  19. Characterization of Mycobacterium paratuberculosis and organisms of the Mycobacterium avium complex by restriction polymorphism of the rRNA gene region. Chiodini, R.J. J. Clin. Microbiol. (1990) [Pubmed]
  20. Loss of heterozygosity and overexpression of the p53 gene in ovarian carcinoma. Frank, T.S., Bartos, R.E., Haefner, H.K., Roberts, J.A., Wilson, M.D., Hubbell, G.P. Mod. Pathol. (1994) [Pubmed]
  21. A polymorphic DNA marker linked to cystic fibrosis is located on chromosome 7. Knowlton, R.G., Cohen-Haguenauer, O., Van Cong, N., Frézal, J., Brown, V.A., Barker, D., Braman, J.C., Schumm, J.W., Tsui, L.C., Buchwald, M. Nature (1985) [Pubmed]
  22. Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA). Zhu, Q., Zhang, M., Rawlings, D.J., Vihinen, M., Hagemann, T., Saffran, D.C., Kwan, S.P., Nilsson, L., Smith, C.I., Witte, O.N., Chen, S.H., Ochs, H.D. J. Exp. Med. (1994) [Pubmed]
  23. A restriction fragment of the C2 gene is a unique marker for C2 deficiency and the uncommon C2 allele C2*B (a marker for type 1 diabetes). Simon, S., Awdeh, Z., Campbell, R.D., Ronco, P., Brink, S.J., Eisenbarth, G.S., Yunis, E.J., Alper, C.A. J. Clin. Invest. (1991) [Pubmed]
  24. Major histocompatibility complex haplotypes and complement C4 alleles in systemic lupus erythematosus. Results of a multicenter study. Hartung, K., Baur, M.P., Coldewey, R., Fricke, M., Kalden, J.R., Lakomek, H.J., Peter, H.H., Schendel, D., Schneider, P.M., Seuchter, S.A. J. Clin. Invest. (1992) [Pubmed]
  25. Cosegregation of the renin allele of the spontaneously hypertensive rat with an increase in blood pressure. Kurtz, T.W., Simonet, L., Kabra, P.M., Wolfe, S., Chan, L., Hjelle, B.L. J. Clin. Invest. (1990) [Pubmed]
  26. Activation of ras oncogenes preceding the onset of neoplasia. Kumar, R., Sukumar, S., Barbacid, M. Science (1990) [Pubmed]
  27. Association between a T cell receptor restriction fragment length polymorphism and systemic lupus erythematosus. Tebib, J.G., Alcocer-Varela, J., Alarcon-Segovia, D., Schur, P.H. J. Clin. Invest. (1990) [Pubmed]
  28. Clonal composition of benign and malignant human thyroid tumors. Namba, H., Matsuo, K., Fagin, J.A. J. Clin. Invest. (1990) [Pubmed]
  29. BglII restriction fragment length polymorphism at the gene locus coding for the leukocyte surface antigen CD37. Virtaneva, K.I., Nevanlinna, H., Schröder, J. Hum. Mol. Genet. (1993) [Pubmed]
  30. An MboI RFLP in the human erythrocyte surface protein band 3-like 1 gene (EPB3L1) on chromosome 7q35-7q36. Showe, M.K., Williams, D., Showe, L.C. Hum. Mol. Genet. (1993) [Pubmed]
  31. A multi-institutional outbreak of highly drug-resistant tuberculosis: epidemiology and clinical outcomes. Frieden, T.R., Sherman, L.F., Maw, K.L., Fujiwara, P.I., Crawford, J.T., Nivin, B., Sharp, V., Hewlett, D., Brudney, K., Alland, D., Kreisworth, B.N. JAMA (1996) [Pubmed]
  32. Major histocompatibility complex restriction fragment length polymorphisms define three diabetogenic haplotypes in BB and BBN rats. Buse, J.B., Rifai-Haddad, R., Lees, S., Taniguchi, H., Chaplin, D., Milford, E.M., Seidman, J.G., Eisenbarth, G.S., Jackson, R.A. J. Exp. Med. (1985) [Pubmed]
  33. Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. Messer, G., Spengler, U., Jung, M.C., Honold, G., Blömer, K., Pape, G.R., Riethmüller, G., Weiss, E.H. J. Exp. Med. (1991) [Pubmed]
  34. Isolation of a complementary DNA clone for the human complement protein C2 and its use in the identification of a restriction fragment length polymorphism. Woods, D.E., Edge, M.D., Colten, H.R. J. Clin. Invest. (1984) [Pubmed]
  35. Hemophilia B (Christmas disease) variants and carrier detection analyzed by DNA probes. Poon, M.C., Chui, D.H., Patterson, M., Starozik, D.M., Dimnik, L.S., Hoar, D.I. J. Clin. Invest. (1987) [Pubmed]
  36. Correlation between a DNA restriction fragment length polymorphism and C4A6 protein. Palsdottir, A., Cross, S.J., Edwards, J.H., Carroll, M.C. Nature (1983) [Pubmed]
  37. Genetic organization of complement receptor-related genes in the mouse. Kingsmore, S.F., Vik, D.P., Kurtz, C.B., Leroy, P., Tack, B.F., Weis, J.H., Seldin, M.F. J. Exp. Med. (1989) [Pubmed]
  38. Dual hereditary jaundice: simultaneous occurrence of mutations causing Gilbert's and Dubin-Johnson syndrome. Cebecauerova, D., Jirasek, T., Budisova, L., Mandys, V., Volf, V., Novotna, Z., Subhanova, I., Hrebicek, M., Elleder, M., Jirsa, M. Gastroenterology (2005) [Pubmed]
  39. Decay-accelerating factor. Genetic polymorphism and linkage to the RCA (regulator of complement activation) gene cluster in humans. Rey-Campos, J., Rubinstein, P., Rodriguez de Cordoba, S. J. Exp. Med. (1987) [Pubmed]
  40. Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans. Evans, W.E., Relling, M.V., Rahman, A., McLeod, H.L., Scott, E.P., Lin, J.S. J. Clin. Invest. (1993) [Pubmed]
  41. Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides. Schumacher, T.N., Kantesaria, D.V., Serreze, D.V., Roopenian, D.C., Ploegh, H.L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  42. Huntington disease-linked restriction fragment length polymorphism localized within band p16.1 of chromosome 4 by in situ hybridization. Magenis, R.E., Gusella, J., Weliky, K., Olson, S., Haight, G., Toth-Fejel, S., Sheehy, R. Am. J. Hum. Genet. (1986) [Pubmed]
  43. Restriction fragment length polymorphism caused by a deletion within the human c-abl gene (ABL). Xu, D.Q., Galibert, F. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
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