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MeSH Review

Circadian Rhythm

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Disease relevance of Circadian Rhythm


Psychiatry related information on Circadian Rhythm


High impact information on Circadian Rhythm

  • RNA from two of these genes, per and tim, is expressed with a circadian rhythm [10].
  • Molecular and genetic characterizations of circadian rhythms in Drosophila indicate that function of an intracellular pacemaker requires the activities of proteins encoded by three genes: period (per), timeless (tim), and doubletime (dbt) [10].
  • Thus, VRI and PDP1, together with dClock itself, comprise a second feedback loop in the Drosophila clock that gives rhythmic expression of dClock, and probably of other genes, to generate accurate circadian rhythms [11].
  • We propose that Clock is uniquely able to induce and organize the core elements of interdependent feedback loops necessary for circadian rhythms [12].
  • We now report that mice carrying a null mutation of the VPAC(2) receptor for VIP and PACAP (Vipr2(-/-)) are incapable of sustaining normal circadian rhythms of rest/activity behavior [13].

Chemical compound and disease context of Circadian Rhythm


Biological context of Circadian Rhythm


Anatomical context of Circadian Rhythm

  • A central pacemaker for the generation of many circadian rhythms in mammals, including the sleep-wake cycle, appears to be located in the suprachiasmatic nucleus, and recent research indicates that both cell bodies and axons containing GABA are present within the bilaterally paired suprachiasmatic nuclei [6].
  • Secretory cells of the chicken pineal gland exhibit light-sensitive circadian rhythms in melatonin release that persist in vitro [24].
  • The circadian rhythms of sleep, melatonin secretion and body core temperature are thought to be generated by the suprachiasmatic nucleus of the hypothalamus, the anatomic locus of the mammalian circadian clock [25].
  • Thus the double amplitude (total extent of variation) of the circadian rhythm in circulating total, T and T helper lymphocytes varied between 0 in March (P greater than 0.30; no rhythm) and up to 46-68% of the 24-h-mean (M) in November, with acrophases (times of maximum, 0) localized in the first half of the night (P less than 0.001) [26].
  • High-level expression of the gene is also seen in particular regions of the forebrain involved in the regulation of circadian rhythms, the endocrine system, and olfactory function, not previously identified in this context [27].

Associations of Circadian Rhythm with chemical compounds


Gene context of Circadian Rhythm


Analytical, diagnostic and therapeutic context of Circadian Rhythm


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