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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Line, Tumor

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Disease relevance of Cell Line, Tumor


High impact information on Cell Line, Tumor


Chemical compound and disease context of Cell Line, Tumor


Biological context of Cell Line, Tumor


Anatomical context of Cell Line, Tumor


Associations of Cell Line, Tumor with chemical compounds


Gene context of Cell Line, Tumor

  • Finally, we show that E2F3 is not required for cellular immortalization but is rate limiting for the proliferation of the resulting tumor cell lines [31].
  • Thus, perforin-dependent cytotoxicity is not only a crucial mechanism of both cytotoxic T lymphocyte- and NK-dependent resistance to injected tumor cell lines, but also operates during viral and chemical carcinogenesis in vivo [32].
  • We describe the isolation and characterization of two novel monocyte chemotactic factors from this tumor cell line [33].
  • RESULTS: In the absence of multidrug resistance, human tumor cell lines with activated ras oncogenes were uniformly more sensitive to most topoisomerase II inhibitors than were cell lines containing wild-type ras alleles [34].
  • These findings have prompted investigations into whether human tumor cells may be transduced with the IL2 gene and whether tumor cell lines could be engineered to release IL2 [35].

Analytical, diagnostic and therapeutic context of Cell Line, Tumor


  1. Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells. Kimchi, A., Wang, X.F., Weinberg, R.A., Cheifetz, S., Massagué, J. Science (1988) [Pubmed]
  2. Two new p73 splice variants, gamma and delta, with different transcriptional activity. De Laurenzi, V., Costanzo, A., Barcaroli, D., Terrinoni, A., Falco, M., Annicchiarico-Petruzzelli, M., Levrero, M., Melino, G. J. Exp. Med. (1998) [Pubmed]
  3. New carbon dioxide-independent basal growth medium for culture of diverse tumor and nontumor cells of human and nonhuman origin. Vistica, D.T., Scudiero, D., Skehan, P., Monks, A., Boyd, M.R. J. Natl. Cancer Inst. (1990) [Pubmed]
  4. Expression of collagenase IV (basement membrane collagenase) activity in murine tumor cell hybrids that differ in metastatic potential. Turpeenniemi-Hujanen, T., Thorgeirsson, U.P., Hart, I.R., Grant, S.S., Liotta, L.A. J. Natl. Cancer Inst. (1985) [Pubmed]
  5. Effects of modulation of basic fibroblast growth factor on tumor growth in vivo. Gross, J.L., Herblin, W.F., Dusak, B.A., Czerniak, P., Diamond, M.D., Sun, T., Eidsvoog, K., Dexter, D.L., Yayon, A. J. Natl. Cancer Inst. (1993) [Pubmed]
  6. Chfr is required for tumor suppression and Aurora A regulation. Yu, X., Minter-Dykhouse, K., Malureanu, L., Zhao, W.M., Zhang, D., Merkle, C.J., Ward, I.M., Saya, H., Fang, G., van Deursen, J., Chen, J. Nat. Genet. (2005) [Pubmed]
  7. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Kuramochi, M., Fukuhara, H., Nobukuni, T., Kanbe, T., Maruyama, T., Ghosh, H.P., Pletcher, M., Isomura, M., Onizuka, M., Kitamura, T., Sekiya, T., Reeves, R.H., Murakami, Y. Nat. Genet. (2001) [Pubmed]
  8. Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. Kim, J., Yu, W., Kovalski, K., Ossowski, L. Cell (1998) [Pubmed]
  9. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Miyashita, T., Reed, J.C. Cell (1995) [Pubmed]
  10. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Vleminckx, K., Vakaet, L., Mareel, M., Fiers, W., van Roy, F. Cell (1991) [Pubmed]
  11. Expression of the atrial natriuretic factor gene in small cell lung cancer tumors and tumor cell lines. Bliss, D.P., Battey, J.F., Linnoila, R.I., Birrer, M.J., Gazdar, A.F., Johnson, B.E. J. Natl. Cancer Inst. (1990) [Pubmed]
  12. Tumor cell proteinase visualization and quantification using a fluorescent transition-state analog probe. Kozlowski, K.A., Wezeman, F.H., Schultz, R.M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  13. ret transforming gene encodes a fusion protein homologous to tyrosine kinases. Takahashi, M., Cooper, G.M. Mol. Cell. Biol. (1987) [Pubmed]
  14. High rate of multilocus deletion in a human tumor cell line. Harwood, J., Tachibana, A., Davis, R., Bhattacharyya, N.P., Meuth, M. Hum. Mol. Genet. (1993) [Pubmed]
  15. Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action. Farrell, N., Kelland, L.R., Roberts, J.D., Van Beusichem, M. Cancer Res. (1992) [Pubmed]
  16. Activated N-ras controls the transformed phenotype of HT1080 human fibrosarcoma cells. Paterson, H., Reeves, B., Brown, R., Hall, A., Furth, M., Bos, J., Jones, P., Marshall, C. Cell (1987) [Pubmed]
  17. Beta 1-6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Dennis, J.W., Laferté, S., Waghorne, C., Breitman, M.L., Kerbel, R.S. Science (1987) [Pubmed]
  18. The RNA component of human telomerase. Feng, J., Funk, W.D., Wang, S.S., Weinrich, S.L., Avilion, A.A., Chiu, C.P., Adams, R.R., Chang, E., Allsopp, R.C., Yu, J. Science (1995) [Pubmed]
  19. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Rampino, N., Yamamoto, H., Ionov, Y., Li, Y., Sawai, H., Reed, J.C., Perucho, M. Science (1997) [Pubmed]
  20. Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity. Nakayama, M., Kayagaki, N., Yamaguchi, N., Okumura, K., Yagita, H. J. Exp. Med. (2000) [Pubmed]
  21. Conditional mutator phenotypes in hMSH2-deficient tumor cell lines. Richards, B., Zhang, H., Phear, G., Meuth, M. Science (1997) [Pubmed]
  22. Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Walz, G., Aruffo, A., Kolanus, W., Bevilacqua, M., Seed, B. Science (1990) [Pubmed]
  23. A novel ligand in lymphocyte-mediated cytotoxicity: expression of the beta subunit of H+ transporting ATP synthase on the surface of tumor cell lines. Das, B., Mondragon, M.O., Sadeghian, M., Hatcher, V.B., Norin, A.J. J. Exp. Med. (1994) [Pubmed]
  24. The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes. Martin, U., Bock, D., Arseniev, L., Tornetta, M.A., Ames, R.S., Bautsch, W., Köhl, J., Ganser, A., Klos, A. J. Exp. Med. (1997) [Pubmed]
  25. Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling. Matsui, T., Sano, K., Tsukamoto, T., Ito, M., Takaishi, T., Nakata, H., Nakamura, H., Chihara, K. J. Clin. Invest. (1993) [Pubmed]
  26. Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross. Wellems, T.E., Panton, L.J., Gluzman, I.Y., do Rosario, V.E., Gwadz, R.W., Walker-Jonah, A., Krogstad, D.J. Nature (1990) [Pubmed]
  27. Overexpression of metallothionein confers resistance to anticancer drugs. Kelley, S.L., Basu, A., Teicher, B.A., Hacker, M.P., Hamer, D.H., Lazo, J.S. Science (1988) [Pubmed]
  28. Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. Vilcek, J., Palombella, V.J., Henriksen-DeStefano, D., Swenson, C., Feinman, R., Hirai, M., Tsujimoto, M. J. Exp. Med. (1986) [Pubmed]
  29. Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties. Detheux, M., Ständker, L., Vakili, J., Münch, J., Forssmann, U., Adermann, K., Pöhlmann, S., Vassart, G., Kirchhoff, F., Parmentier, M., Forssmann, W.G. J. Exp. Med. (2000) [Pubmed]
  30. Selection of strongly immunogenic "tum-" variants from tumors at high frequency using 5-azacytidine. Frost, P., Liteplo, R.G., Donaghue, T.P., Kerbel, R.S. J. Exp. Med. (1984) [Pubmed]
  31. E2f3 is critical for normal cellular proliferation. Humbert, P.O., Verona, R., Trimarchi, J.M., Rogers, C., Dandapani, S., Lees, J.A. Genes Dev. (2000) [Pubmed]
  32. Decreased tumor surveillance in perforin-deficient mice. van den Broek, M.E., Kägi, D., Ossendorp, F., Toes, R., Vamvakas, S., Lutz, W.K., Melief, C.J., Zinkernagel, R.M., Hengartner, H. J. Exp. Med. (1996) [Pubmed]
  33. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. Van Damme, J., Proost, P., Lenaerts, J.P., Opdenakker, G. J. Exp. Med. (1992) [Pubmed]
  34. The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis. Koo, H.M., Gray-Goodrich, M., Kohlhagen, G., McWilliams, M.J., Jeffers, M., Vaigro-Wolff, A., Alvord, W.G., Monks, A., Paull, K.D., Pommier, Y., Vande Woude, G.F. J. Natl. Cancer Inst. (1999) [Pubmed]
  35. Transduction of the IL2 gene into human acute leukemia cells: induction of tumor rejection without modifying cell proliferation and IL2 receptor expression. Cignetti, A., Guarini, A., Carbone, A., Forni, M., Cronin, K., Forni, G., Gansbacher, B., Foa, R. J. Natl. Cancer Inst. (1994) [Pubmed]
  36. Preferential interaction of a novel tumor surface protein (p38.5) with naive natural killer cells. Das, B., Mondragon, M.O., Tao, S.Z., Norin, A.J. J. Exp. Med. (1997) [Pubmed]
  37. Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis. von Marschall, Z., Scholz, A., Cramer, T., Schäfer, G., Schirner, M., Oberg, K., Wiedenmann, B., Höcker, M., Rosewicz, S. J. Natl. Cancer Inst. (2003) [Pubmed]
  38. Expression of insulinlike growth factor (IGF) and IGF-binding protein genes in human lung tumor cell lines. Reeve, J.G., Brinkman, A., Hughes, S., Mitchell, J., Schwander, J., Bleehen, N.M. J. Natl. Cancer Inst. (1992) [Pubmed]
  39. Effect of exposure to calcium entry blockers on doxorubicin accumulation and cytotoxicity in multidrug-resistant cells. Bruno, N.A., Slate, D.L. J. Natl. Cancer Inst. (1990) [Pubmed]
  40. CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells. Barnhart, B.C., Legembre, P., Pietras, E., Bubici, C., Franzoso, G., Peter, M.E. EMBO J. (2004) [Pubmed]
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