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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Mesangial Cells

 
 
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Disease relevance of Mesangial Cells

 

High impact information on Mesangial Cells

 

Chemical compound and disease context of Mesangial Cells

 

Biological context of Mesangial Cells

 

Anatomical context of Mesangial Cells

  • We therefore examined the influence of platelet-activating factor (PAF), (a mediator of inflammation released from leukocytes) and of phagocytosis of zymosan on arachidonic acid metabolism and on cell contractility in rat glomerular mesangial cells in culture [20].
  • We show here that, contrary to the situation in T cells, FK506 activates transcription factor NF-kappaB in nonlymphoid cells such as fibroblasts and renal mesangial cells [21].
  • ET-1 (greater than or equal to 1 nM) reduced the cross-sectional area of rat mesangial cells cultured on three-dimensional gels of collagen type I. ET-1 also caused complex rearrangements of F-actin microfilaments consistent with a motile response [22].
  • These findings indicate that FN is an important constituent of the glomerulus, and they are compatible with the assumption that, in the glomerulus, as in cultured cells, FN is involved in cell-to-cell (mesangial-mesangial, mesangial-endothelial) and cell-to-substrate (mesangial cell-mesangial matrix, epithelium-GBM, endothelium-GBM) attachment [23].
  • Activated macrophages trigger mesangial cells to express an array of inflammation-associated genes via activation of NF-kappaB and AP-1 [24].
 

Associations of Mesangial Cells with chemical compounds

 

Gene context of Mesangial Cells

 

Analytical, diagnostic and therapeutic context of Mesangial Cells

References

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  2. Rat glomerular mesangial cells synthesize basic fibroblast growth factor. Release, upregulated synthesis, and mitogenicity in mesangial proliferative glomerulonephritis. Floege, J., Eng, E., Lindner, V., Alpers, C.E., Young, B.A., Reidy, M.A., Johnson, R.J. J. Clin. Invest. (1992) [Pubmed]
  3. Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation. Johnson, R.J., Iida, H., Alpers, C.E., Majesky, M.W., Schwartz, S.M., Pritzi, P., Gordon, K., Gown, A.M. J. Clin. Invest. (1991) [Pubmed]
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  19. Low density lipoprotein enhances the cellular action of arginine vasopressin in rat glomerular mesangial cells in culture. Ishikawa, S., Kawasumi, M., Okada, K., Saito, T. J. Clin. Invest. (1994) [Pubmed]
  20. Effect of platelet-activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells. Schlondorff, D., Satriano, J.A., Hagege, J., Perez, J., Baud, L. J. Clin. Invest. (1984) [Pubmed]
  21. Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy. Muraoka, K., Fujimoto, K., Sun, X., Yoshioka, K., Shimizu, K., Yagi, M., Bose, H., Miyazaki, I., Yamamoto, K. J. Clin. Invest. (1996) [Pubmed]
  22. Endothelin-1 stimulates contraction of rat glomerular mesangial cells and potentiates beta-adrenergic-mediated cyclic adenosine monophosphate accumulation. Simonson, M.S., Dunn, M.J. J. Clin. Invest. (1990) [Pubmed]
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  26. Reactive oxygen production by cultured rat glomerular mesangial cells during phagocytosis is associated with stimulation of lipoxygenase activity. Baud, L., Hagege, J., Sraer, J., Rondeau, E., Perez, J., Ardaillou, R. J. Exp. Med. (1983) [Pubmed]
  27. Endothelin (ET)-3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells. Owada, A., Tomita, K., Terada, Y., Sakamoto, H., Nonoguchi, H., Marumo, F. J. Clin. Invest. (1994) [Pubmed]
  28. Nitric oxide amplifies interleukin 1-induced cyclooxygenase-2 expression in rat mesangial cells. Tetsuka, T., Daphna-Iken, D., Miller, B.W., Guan, Z., Baier, L.D., Morrison, A.R. J. Clin. Invest. (1996) [Pubmed]
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  30. Platelet-derived growth factor synthesis in mesangial cells: induction by multiple peptide mitogens. Silver, B.J., Jaffer, F.E., Abboud, H.E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
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