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MeSH Review

Immune Tolerance

 
 
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Disease relevance of Immune Tolerance

 

High impact information on Immune Tolerance

  • The protective effect may be explained by higher levels of class III VNTR-associated INS mRNA in thymus such that elevated levels of preproinsulin protein enhance immune tolerance to preproinsulin, a key autoantigen in type 1 diabetes pathogenesis [6].
  • Insulin was detected in all thymus tissues examined and class III VNTR alleles were associated with 2- to 3-fold higher INS mRNA levels than class I. We therefore propose higher levels of thymic INS expression, facilitating immune tolerance induction, as a mechanism for the dominant protective effect of class III alleles [7].
  • A critical role for Stat3 signaling in immune tolerance [8].
  • Regulatory T cells (T(reg) cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant immune tolerance to self [9].
  • If the assumption that immune tolerance determines the range of anti-Gal specificity is correct, then anti-Gal from individuals lacking the B antigen (A and O blood types) would be expected to interact with both Gal alpha 1----3Gal and Gal alpha 1----3(Fuc alpha 1----2)Gal epitopes [10].
 

Chemical compound and disease context of Immune Tolerance

 

Biological context of Immune Tolerance

 

Anatomical context of Immune Tolerance

 

Associations of Immune Tolerance with chemical compounds

 

Gene context of Immune Tolerance

 

Analytical, diagnostic and therapeutic context of Immune Tolerance

References

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  2. The protooncogene MYC can break B cell tolerance. Refaeli, Y., Field, K.A., Turner, B.C., Trumpp, A., Bishop, J.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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  18. Immune tolerance to combined organ and bone marrow transplants after fractionated lymphoid irradiation involves regulatory NK T cells and clonal deletion. Higuchi, M., Zeng, D., Shizuru, J., Gworek, J., Dejbakhsh-Jones, S., Taniguchi, M., Strober, S. J. Immunol. (2002) [Pubmed]
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  24. Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system. Kayisli, U.A., Selam, B., Guzeloglu-Kayisli, O., Demir, R., Arici, A. J. Immunol. (2003) [Pubmed]
  25. Covalent modification as a mechanism for the breakdown of immune tolerance to pyruvate dehydrogenase complex in the mouse. Palmer, J.M., Robe, A.J., Burt, A.D., Kirby, J.A., Jones, D.E. Hepatology (2004) [Pubmed]
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  37. Immune tolerance induced by donor antigen and cyclophosphamide in rat fetal small bowel transplantation. Nakao, M., Taguchi, T., Ogita, K., Nishimoto, Y., Suita, S. Fukuoka Igaku Zasshi (2005) [Pubmed]
  38. Influence of recipient pretreatment with donor spleen cells and 15-deoxyspergualin on rat skin graft survival. Krzymański, M., Oko, A., Waaga, A.M., Pawliczak, E., Wiktorowicz, K. Arch. Immunol. Ther. Exp. (Warsz.) (1997) [Pubmed]
 
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