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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Haplotypes

 
 
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Disease relevance of Haplotypes

 

Psychiatry related information on Haplotypes

 

High impact information on Haplotypes

  • A search for congenic pairs of mice expressing the responder and nonresponder H2 haplotypes on the same background revealed that these strains responded as a function of their H2 haplotype, not of their inbred background [11].
  • We refined the chromosomal interval using homozygosity mapping and haplotype analyses and identified the MMACHC gene [12].
  • This gene is the strongest candidate among the 42 genes in the Idd5.2 region; a naturally occurring mutation in the protective Idd5.2 haplotype results in loss of function of the Nramp1 protein [13].
  • Combined analysis of the C2 and BF haplotypes and CFH variants shows that variation in the two loci can predict the clinical outcome in 74% of the affected individuals and 56% of the controls [14].
  • We found that natural killer cell-activating receptor Ly49P specifically recognized MCMV-infected cells, dependent on the presence of the H2 (k) haplotype [15].
 

Chemical compound and disease context of Haplotypes

 

Biological context of Haplotypes

 

Anatomical context of Haplotypes

  • The aberrant expression of tctex-1 is solely dependent on the t haplotype genes and occurs only in germ cells [25].
  • The suppression induced by this monoclonal T-cell product is restricted by both H-2 and Igh-1 genes whereas anti-HEL antibodies bearing a predominant idiotype are induced in all mice strains tested, irrespective of their H-2 haplotype or Igh-1 allotype [26].
  • Tumor targets and concanovalin A (ConA) lymphoblasts from a variety of H2 haplotypes were examined for their susceptibility to lysis by Ly-49D+ NK cells [27].
  • Normal individuals with an HLA haplotype containing either DR2, MT1, or B8/DR3 are more likely to have abnormally prolonged Fc receptor-mediated mononuclear phagocyte system (MPS) clearance of IgG-sensitized autologous erythrocytes than their normal counterparts without such haplotypes [28].
  • The analysis of athymic radiation chimeras using adult thymectomized recipients of distinct H-Y/H-2 haplotypes, reconstituted with bone marrow from H-2Db transgenic females, demonstrates that all IEL subsets present in unmanipulated transgenic animals develop in the absence of a thymus [29].
 

Associations of Haplotypes with chemical compounds

  • The haplotype confers a higher risk of glucose intolerance and T2D to obese children and their parents and associates with increased serum levels of soluble ENPP1 protein in children [30].
  • We have now isolated and sequenced A alpha cDNA clones from five other mouse haplotypes: d, b, f, u, and q [23].
  • A significantly increased frequency (P less than 0.03) of the HLA-DR2 haplotype occurred in the eight patients with the most substantial response to methotrexate [31].
  • Comparison of the sequences of the polymorphic amino-terminal domain of the DQ beta chain showed that the three 'susceptibility' haplotypes all had a neutral alanine or valine at position 57 [32].
  • We studied 17 members of this family and found a low C3 level from activation of the alternative pathway in the haplotype A3,B7 carriers [33].
 

Gene context of Haplotypes

 

Analytical, diagnostic and therapeutic context of Haplotypes

  • In a two-stage, case-control study, we analyzed the frequency of MHC class I antigens and class II haplotypes in people with either transient or persistent HBV infection [39].
  • Since most patients have a relative with one haplotype mismatch, advances in this method will increase the availability of hematopoietic-cell transplantation as curative therapy for acute leukemia [40].
  • Gene mapping within the T/t complex of the mouse. II. Anomalous position of the H-2 complex in t haplotypes [41].
  • Blood transfusion in which there is a common HLA haplotype or shared HLA-B and HLA-DR antigens induces tolerance to donor antigens [42].
  • In a meta-analysis of over 900 individuals from Sweden and over 1,000 individuals from Belgium and England, we now report that subjects homozygous with respect to the haplotypes -2,578A/-1,154A/-634G or -2,578A/-1,154G/-634G in the VEGF promoter/leader sequence had a 1.8 times greater risk of ALS (P = 0.00004) [43].

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