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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Genotype

 
 
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Disease relevance of Genotype

 

Psychiatry related information on Genotype

 

High impact information on Genotype

 

Chemical compound and disease context of Genotype

 

Biological context of Genotype

 

Anatomical context of Genotype

  • To determine whether p63/6.9 is a direct gene product of the T/t complex, testicular cytoplasmic RNA from mice bearing the genotypes +/+, +/t and t/t was translated in a rabbit reticulocyte-derived cell-free system, and translated products were analyzed by two-dimensional gel electrophoresis [25].
  • By means of analysis of alpha-fetoprotein expression in livers of embryo aggregation chimeras derived from mice of different raf genotypes it was possible to conclude that the product of the raf locus is expressed as a hepatocyte autonomous function that acts in trans to regulate the level of alpha-fetoprotein messenger RNA [26].
  • Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype [27].
  • Contrasting genetic effects of KIR/HLA combinations have been observed in infectious and autoimmune diseases, where genotypes associated with NK cell activation seem to be protective or to confer susceptibility, respectively [28].
  • However, mice with an IMPDH II(+/-), HPRT(-/o) genotype demonstrate significantly decreased lymphocyte responsiveness to stimulation with anti-CD3 and anti-CD28 antibodies and show a 30% mean reduction in GTP levels in lymphocytes activated by these antibodies [29].
 

Associations of Genotype with chemical compounds

  • RESULTS: The B1 variant of the CETP gene was associated with both higher plasma CETP concentrations (mean [+/-SD], 2.29+/-0.62 microg per milliliter for the B1B1 genotype vs. 1.76+/-0.51 microg per milliliter for the B2B2 genotype) and lower HDL cholesterol concentrations (34+/-8 vs. 39+/-10 mg per deciliter) [30].
  • We intercrossed mice heterozygous for two null alleles (Irs1+/- and Irs2+/-) and investigated growth and glucose metabolism in mice with viable genotypes [31].
  • Among patients with HCV genotype 1 infection, the best response occurred in those who were treated for 48 weeks with interferon and ribavirin [32].
  • The frequencies of the carbamoyl-phosphate synthetase genotypes in the study population were assessed for Hardy-Weinberg equilibrium [33].
  • Aldosterone and ANP concentrations are not affected by the genotype [34].
 

Gene context of Genotype

  • We have also identified a unique combination of the ACT/AA and APOE 4/4 genotypes as a potential susceptibility marker for AD, as its frequency was 1/17 in the AD group compared to 1/313 in the general population control [35].
  • Although cumulative mortality is similar regardless of the genotype, the percentage of cardiac events that are lethal is significantly higher in families with mutations at the LQT3 locus [36].
  • By correlating the fates of Z1.ppp and Z4.aaa with the lin-12 genotype of nearly every cell in these mosaics, we conclude that lin-12 function is VU cell autonomous [37].
  • The fetus, semiallograft by its genotype, escapes maternal allorecognition by downregulation of HLA-A and HLA-B molecules at this interface [38].
  • The GSTM1 and GSTT1 genotypes were not associated with survival or clinical response [39].
 

Analytical, diagnostic and therapeutic context of Genotype

References

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  15. Association between the T29-->C polymorphism in the transforming growth factor beta1 gene and breast cancer among elderly white women: The Study of Osteoporotic Fractures. Ziv, E., Cauley, J., Morin, P.A., Saiz, R., Browner, W.S. JAMA (2001) [Pubmed]
  16. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. Collins, R.G., Velji, R., Guevara, N.V., Hicks, M.J., Chan, L., Beaudet, A.L. J. Exp. Med. (2000) [Pubmed]
  17. Determinants of mild clinical symptoms in cystic fibrosis patients. Residual chloride secretion measured in rectal biopsies in relation to the genotype. Veeze, H.J., Halley, D.J., Bijman, J., de Jongste, J.C., de Jonge, H.R., Sinaasappel, M. J. Clin. Invest. (1994) [Pubmed]
  18. Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy. Nowell, S., Sweeney, C., Winters, M., Stone, A., Lang, N.P., Hutchins, L.F., Kadlubar, F.F., Ambrosone, C.B. J. Natl. Cancer Inst. (2002) [Pubmed]
  19. Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients. Romero-Gómez, M., Del Mar Viloria, M., Andrade, R.J., Salmerón, J., Diago, M., Fernández-Rodríguez, C.M., Corpas, R., Cruz, M., Grande, L., Vázquez, L., Muñoz-De-Rueda, P., López-Serrano, P., Gila, A., Gutiérrez, M.L., Pérez, C., Ruiz-Extremera, A., Suárez, E., Castillo, J. Gastroenterology (2005) [Pubmed]
  20. Novel inheritance of the murine severe combined anemia and thrombocytopenia (Scat) phenotype. Peters, L.L., Barker, J.E. Cell (1993) [Pubmed]
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  22. A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients. Cucca, F., Goy, J.V., Kawaguchi, Y., Esposito, L., Merriman, M.E., Wilson, A.J., Cordell, H.J., Bain, S.C., Todd, J.A. Nat. Genet. (1998) [Pubmed]
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  26. Raf, a trans-acting locus, regulates the alpha-fetoprotein gene in a cell-autonomous manner. Vogt, T.F., Solter, D., Tilghman, S.M. Science (1987) [Pubmed]
  27. Cytotoxic T-cell responses in mice infected with influenza and vaccinia viruses vary in magnitude with H-2 genotype. Doherty, P.C., Biddison, W.E., Bennink, J.R., Knowles, B.B. J. Exp. Med. (1978) [Pubmed]
  28. Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci. Carrington, M., Wang, S., Martin, M.P., Gao, X., Schiffman, M., Cheng, J., Herrero, R., Rodriguez, A.C., Kurman, R., Mortel, R., Schwartz, P., Glass, A., Hildesheim, A. J. Exp. Med. (2005) [Pubmed]
  29. Inhibition of T lymphocyte activation in mice heterozygous for loss of the IMPDH II gene. Gu, J.J., Stegmann, S., Gathy, K., Murray, R., Laliberte, J., Ayscue, L., Mitchell, B.S. J. Clin. Invest. (2000) [Pubmed]
  30. The role of a common variant of the cholesteryl ester transfer protein gene in the progression of coronary atherosclerosis. The Regression Growth Evaluation Statin Study Group. Kuivenhoven, J.A., Jukema, J.W., Zwinderman, A.H., de Knijff, P., McPherson, R., Bruschke, A.V., Lie, K.I., Kastelein, J.J. N. Engl. J. Med. (1998) [Pubmed]
  31. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Withers, D.J., Burks, D.J., Towery, H.H., Altamuro, S.L., Flint, C.L., White, M.F. Nat. Genet. (1999) [Pubmed]
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  34. Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide. Lopez, M.J., Wong, S.K., Kishimoto, I., Dubois, S., Mach, V., Friesen, J., Garbers, D.L., Beuve, A. Nature (1995) [Pubmed]
  35. APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism. Kamboh, M.I., Sanghera, D.K., Ferrell, R.E., DeKosky, S.T. Nat. Genet. (1995) [Pubmed]
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