MeSH Review:
Osteoclasts
- Use of dichloromethylene diphosphonate in metastatic bone disease. Jung, A., Chantraine, A., Donath, A., van Ouwenaller, C., Turnill, D., Mermillod, B., Kitler, M.E. N. Engl. J. Med. (1983)
- Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Jimi, E., Aoki, K., Saito, H., D'Acquisto, F., May, M.J., Nakamura, I., Sudo, T., Kojima, T., Okamoto, F., Fukushima, H., Okabe, K., Ohya, K., Ghosh, S. Nat. Med. (2004)
- Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Iotsova, V., Caamaño, J., Loy, J., Yang, Y., Lewin, A., Bravo, R. Nat. Med. (1997)
- Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Honore, P., Luger, N.M., Sabino, M.A., Schwei, M.J., Rogers, S.D., Mach, D.B., O'keefe, P.F., Ramnaraine, M.L., Clohisy, D.R., Mantyh, P.W. Nat. Med. (2000)
- Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M.T., Martin, T.J. Endocr. Rev. (1999)
- Sex steroids and bone. Compston, J.E. Physiol. Rev. (2001)
- TSH is a negative regulator of skeletal remodeling. Abe, E., Marians, R.C., Yu, W., Wu, X.B., Ando, T., Li, Y., Iqbal, J., Eldeiry, L., Rajendren, G., Blair, H.C., Davies, T.F., Zaidi, M. Cell (2003)
- The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J.M., Behringer, R.R., de Crombrugghe, B. Cell (2002)
- Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. Kornak, U., Kasper, D., Bösl, M.R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., Jentsch, T.J. Cell (2001)
- Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation. Matsuo, K., Owens, J.M., Tonko, M., Elliott, C., Chambers, T.J., Wagner, E.F. Nat. Genet. (2000)
- Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. Kameda, T., Mano, H., Yuasa, T., Mori, Y., Miyazawa, K., Shiokawa, M., Nakamaru, Y., Hiroi, E., Hiura, K., Kameda, A., Yang, N.N., Hakeda, Y., Kumegawa, M. J. Exp. Med. (1997)
- An essential role of cytosolic phospholipase A2alpha in prostaglandin E2-mediated bone resorption associated with inflammation. Miyaura, C., Inada, M., Matsumoto, C., Ohshiba, T., Uozumi, N., Shimizu, T., Ito, A. J. Exp. Med. (2003)
- Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure. Sato, M., Grasser, W., Endo, N., Akins, R., Simmons, H., Thompson, D.D., Golub, E., Rodan, G.A. J. Clin. Invest. (1991)
- DNA synthesis is not necessary for osteoclastic responses to parathyroid hormone in cultured fetal rat long bones. Lorenzo, J.A., Raisz, L.G., Hock, J.M. J. Clin. Invest. (1983)
- Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. Hughes, D.E., Dai, A., Tiffee, J.C., Li, H.H., Mundy, G.R., Boyce, B.F. Nat. Med. (1996)
- c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption. Tanaka, S., Amling, M., Neff, L., Peyman, A., Uhlmann, E., Levy, J.B., Baron, R. Nature (1996)
- Vav3 regulates osteoclast function and bone mass. Faccio, R., Teitelbaum, S.L., Fujikawa, K., Chappel, J., Zallone, A., Tybulewicz, V.L., Ross, F.P., Swat, W. Nat. Med. (2005)
- RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Takayanagi, H., Kim, S., Matsuo, K., Suzuki, H., Suzuki, T., Sato, K., Yokochi, T., Oda, H., Nakamura, K., Ida, N., Wagner, E.F., Taniguchi, T. Nature (2002)
- Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Lagasse, E., Weissman, I.L. Cell (1997)
- Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Lacey, D.L., Timms, E., Tan, H.L., Kelley, M.J., Dunstan, C.R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y.X., Kaufman, S., Sarosi, I., Shalhoub, V., Senaldi, G., Guo, J., Delaney, J., Boyle, W.J. Cell (1998)
- Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nutt, S.L., Heavey, B., Rolink, A.G., Busslinger, M. Nature (1999)
- Growth hormone and bone. Ohlsson, C., Bengtsson, B.A., Isaksson, O.G., Andreassen, T.T., Slootweg, M.C. Endocr. Rev. (1998)
- Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. Tondravi, M.M., McKercher, S.R., Anderson, K., Erdmann, J.M., Quiroz, M., Maki, R., Teitelbaum, S.L. Nature (1997)
- Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Gelb, B.D., Shi, G.P., Chapman, H.A., Desnick, R.J. Science (1996)
- TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Lomaga, M.A., Yeh, W.C., Sarosi, I., Duncan, G.S., Furlonger, C., Ho, A., Morony, S., Capparelli, C., Van, G., Kaufman, S., van der Heiden, A., Itie, A., Wakeham, A., Khoo, W., Sasaki, T., Cao, Z., Penninger, J.M., Paige, C.J., Lacey, D.L., Dunstan, C.R., Boyle, W.J., Goeddel, D.V., Mak, T.W. Genes Dev. (1999)
- Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice. Weilbaecher, K.N., Motyckova, G., Huber, W.E., Takemoto, C.M., Hemesath, T.J., Xu, Y., Hershey, C.L., Dowland, N.R., Wells, A.G., Fisher, D.E. Mol. Cell (2001)
- NFAT and Osterix cooperatively regulate bone formation. Koga, T., Matsui, Y., Asagiri, M., Kodama, T., de Crombrugghe, B., Nakashima, K., Takayanagi, H. Nat. Med. (2005)
- Increased osteoclast development after estrogen loss: mediation by interleukin-6. Jilka, R.L., Hangoc, G., Girasole, G., Passeri, G., Williams, D.C., Abrams, J.S., Boyce, B., Broxmeyer, H., Manolagas, S.C. Science (1992)
- Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. Udagawa, N., Takahashi, N., Katagiri, T., Tamura, T., Wada, S., Findlay, D.M., Martin, T.J., Hirota, H., Taga, T., Kishimoto, T., Suda, T. J. Exp. Med. (1995)
- IL-1 receptor-associated kinase M is a central regulator of osteoclast differentiation and activation. Li, H., Cuartas, E., Cui, W., Choi, Y., Crawford, T.D., Ke, H.Z., Kobayashi, K.S., Flavell, R.A., Vignery, A. J. Exp. Med. (2005)
- Echistatin is a potent inhibitor of bone resorption in culture. Sato, M., Sardana, M.K., Grasser, W.A., Garsky, V.M., Murray, J.M., Gould, R.J. J. Cell Biol. (1990)