The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Capillaries


Psychiatry related information on Capillaries


High impact information on Capillaries


Chemical compound and disease context of Capillaries

  • The distribution of red cells in the capillaries, determined in histological sections, did not differ appreciably under hypoxia due to reduced O2 in respiration air (12%) or asphyxia [11].
  • Several interpretations of this result are possible, including the postulate that intermittent blood flow occurs in all 9L tumor capillaries, which results in the majority of the binding of misonidazole occurring during the periods of transient hypoxia [12].
  • Endogenous lipopolysaccharide (LPS) is continually absorbed from the gut into intestinal capillaries, and low-grade portal venous endotoxemia is the status quo [13].
  • Since alloxan-diabetic dogs and galactosemic dogs develop microaneurysms, occluded capillaries, and other retinal lesions characteristic of diabetic retinopathy in human patients, these studies suggest that retinopathy can develop in the absence of extraordinary in vitro platelet aggregation [14].
  • Rectal biopsies from five patients with clindamycin-associated colitis were studied with the intention of identifying fibrin thrombi in capillaries [15].

Biological context of Capillaries

  • Combined sustained elevation of Ang-1 and VEGF(165) was associated with an induction of hematopoiesis and increased marrow cellularity followed by proliferation of capillaries and expansion of sinusoidal space [16].
  • We generated mice in which the Dll4 gene was replaced with a reporter gene, and found that Dll4 expression is initially restricted to large arteries in the embryo, whereas in adult mice and tumor models, Dll4 is specifically expressed in smaller arteries and microvessels, with a striking break in expression just as capillaries merge into venules [17].
  • Under these conditions, basic FGF is a potent inducer of smooth muscle cell proliferation in the vascular wall as well as of new capillaries [18].
  • During fetal life, human liver sinusoids, which differentiate between 4 and 12 weeks of gestation from capillaries of the septum transversum, must support an important hematopoietic function and acquire the structural and functional characteristics of adult sinusoids [19].
  • In the second set of experiments, in which oncotic pressure in the postglomerular capillaries was elevated by hyperoncotic exchange transfusion, administration of ANP did not result in natriuresis, even though GFR increased by the same magnitude as that seen in isooncotic animals given ANP [20].

Anatomical context of Capillaries


Associations of Capillaries with chemical compounds

  • Two distinct bands of dopamine terminals were found in the lateral median eminence: an inner band which overlapped the gonadotropin-releasing hormone terminals and an outer band which appeared juxtaposed to portal capillaries [26].
  • However, histologically, no fibrin thrombi were noted in capillaries and vessels, a characteristic finding in warfarin necrosis [27].
  • Immunofluorescence study revealed binding of antibody fragments and rat C3 along the capillaries of lung, heart, and liver 5 min after injection [28].
  • These results suggest that the carbonic anhydrase of isolated lungs accelerates the conversion of H2CO3 to CO2 and enhances COW elimination as perfusate passes through the pulmonary capillaries, and that the enzyme may be present on the capillary endothelial surface [29].
  • The ability to induce new formation of capillaries in the cornea was tested for ceruloplasmin, the copper carrier of serum, for fragments of the ceruloplasmin molecule with and without copper, for heparin, and for glycyl-L-histidyl-L-lysine, bound or not bound to copper ions [30].

Gene context of Capillaries


Analytical, diagnostic and therapeutic context of Capillaries


  1. Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR. Feinberg, H., Mitchell, D.A., Drickamer, K., Weis, W.I. Science (2001) [Pubmed]
  2. Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis. Coussens, L.M., Raymond, W.W., Bergers, G., Laig-Webster, M., Behrendtsen, O., Werb, Z., Caughey, G.H., Hanahan, D. Genes Dev. (1999) [Pubmed]
  3. Effect of acetazolamide on cerebral blood flow and cerebral metabolic rate for oxygen. Vorstrup, S., Henriksen, L., Paulson, O.B. J. Clin. Invest. (1984) [Pubmed]
  4. Endothelial characteristics of glomerular capillaries in normal, mercuric chloride-induced, and gentamicin-induced acute renal failure in the rat. Bulger, R.E., Eknoyan, G., Purcell, D.J., Dobyan, D.C. J. Clin. Invest. (1983) [Pubmed]
  5. The effect of P-glycoprotein on paclitaxel brain and brain tumor distribution in mice. Gallo, J.M., Li, S., Guo, P., Reed, K., Ma, J. Cancer Res. (2003) [Pubmed]
  6. The relationship of amyloid plaques to cerebral capillaries in Alzheimer's disease. Kawai, M., Kalaria, R.N., Harik, S.I., Perry, G. Am. J. Pathol. (1990) [Pubmed]
  7. Alcohol consumption alters monoamine oxidase activities in brain structures: relation to ethanol craving. Zimatkin, S.M., Tsydik, V.F., Lelevich, V.V. Cas. Lek. Cesk. (1997) [Pubmed]
  8. Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium. Jarasch, E.D., Grund, C., Bruder, G., Heid, H.W., Keenan, T.W., Franke, W.W. Cell (1981) [Pubmed]
  9. Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. Schweigerer, L., Neufeld, G., Friedman, J., Abraham, J.A., Fiddes, J.C., Gospodarowicz, D. Nature (1987) [Pubmed]
  10. Transferrin receptor on endothelium of brain capillaries. Jefferies, W.A., Brandon, M.R., Hunt, S.V., Williams, A.F., Gatter, K.C., Mason, D.Y. Nature (1984) [Pubmed]
  11. Hypoxia-induced acute changes in capillary and fiber density and capillary red cell distribution in the rat heart. Vetterlein, F., Hemeling, H., Sammler, J., Pethö, A., Schmidt, G. Circ. Res. (1989) [Pubmed]
  12. Distribution of misonidazole adducts in 9L gliosarcoma tumors and spheroids: implications for oxygen distribution. Franko, A.J., Koch, C.J., Boisvert, D.P. Cancer Res. (1992) [Pubmed]
  13. Endogenous gut-derived bacterial endotoxin tonically primes pancreatic secretion of insulin in normal rats. Cornell, R.P. Diabetes (1985) [Pubmed]
  14. Platelet aggregation in experimental diabetes and experimental galactosemia. Kern, T.S., Engerman, R.L. Diabetes (1984) [Pubmed]
  15. Fibrin thrombi, a cause of clindamycin-associated colitis? Bogomoletz, W.V. Gut (1976) [Pubmed]
  16. Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. Hattori, K., Dias, S., Heissig, B., Hackett, N.R., Lyden, D., Tateno, M., Hicklin, D.J., Zhu, Z., Witte, L., Crystal, R.G., Moore, M.A., Rafii, S. J. Exp. Med. (2001) [Pubmed]
  17. Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Gale, N.W., Dominguez, M.G., Noguera, I., Pan, L., Hughes, V., Valenzuela, D.M., Murphy, A.J., Adams, N.C., Lin, H.C., Holash, J., Thurston, G., Yancopoulos, G.D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  18. Vascular response to basic fibroblast growth factor when infused onto the normal adventitia or into the injured media of the rat carotid artery. Cuevas, P., Gonzalez, A.M., Carceller, F., Baird, A. Circ. Res. (1991) [Pubmed]
  19. Structural and functional differentiation of sinusoidal endothelial cells during liver organogenesis in humans. Couvelard, A., Scoazec, J.Y., Dauge, M.C., Bringuier, A.F., Potet, F., Feldmann, G. Blood (1996) [Pubmed]
  20. Modulation of the natriuretic response to atrial natriuretic peptide by alterations in peritubular Starling forces in the rat. Mendez, R.E., Dunn, B.R., Troy, J.L., Brenner, B.M. Circ. Res. (1986) [Pubmed]
  21. Viscoelastic properties of erythrocyte membranes in high-frequency electric fields. Engelhardt, H., Gaub, H., Sackmann, E. Nature (1984) [Pubmed]
  22. Brain grafts reverse hypogonadism of gonadotropin releasing hormone deficiency. Krieger, D.T., Perlow, M.J., Gibson, M.J., Davies, T.F., Zimmerman, E.A., Ferin, M., Charlton, H.M. Nature (1982) [Pubmed]
  23. Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. King, G.L., Goodman, A.D., Buzney, S., Moses, A., Kahn, C.R. J. Clin. Invest. (1985) [Pubmed]
  24. Endothelin-1 mRNA is widely expressed in porcine and human tissues. Nunez, D.J., Brown, M.J., Davenport, A.P., Neylon, C.B., Schofield, J.P., Wyse, R.K. J. Clin. Invest. (1990) [Pubmed]
  25. Macrophage infiltration into experimental brain metastases: occurrence through an intact blood-brain barrier. Schackert, G., Simmons, R.D., Buzbee, T.M., Hume, D.A., Fidler, I.J. J. Natl. Cancer Inst. (1988) [Pubmed]
  26. Fluorescence-immunocytochemistry: simultaneous localization of catecholamines and gonadotropin-releasing hormone. McNeill, T.H., Sladek, J.R. Science (1978) [Pubmed]
  27. Cutaneous necrosis caused by systemically administered heparin. Kelly, R.A., Gelfand, J.A., Pincus, S.H. JAMA (1981) [Pubmed]
  28. In vivo effects of monoclonal antibodies that functionally inhibit complement regulatory proteins in rats. Matsuo, S., Ichida, S., Takizawa, H., Okada, N., Baranyi, L., Iguchi, A., Morgan, B.P., Okada, H. J. Exp. Med. (1994) [Pubmed]
  29. Direct evidence of participation of rat lung carbonic anhydrase in CO2 reactions. Crandall, E.D., O'Brasky, J.E. J. Clin. Invest. (1978) [Pubmed]
  30. Ceruloplasmin, copper ions, and angiogenesis. Raju, K.S., Alessandri, G., Ziche, M., Gullino, P.M. J. Natl. Cancer Inst. (1982) [Pubmed]
  31. Amount and distribution of carbonic anhydrases CA I and CA II in the gastrointestinal tract. Lönnerholm, G., Selking, O., Wistrand, P.J. Gastroenterology (1985) [Pubmed]
  32. Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. Hisa, T., Spence, S.E., Rachel, R.A., Fujita, M., Nakamura, T., Ward, J.M., Devor-Henneman, D.E., Saiki, Y., Kutsuna, H., Tessarollo, L., Jenkins, N.A., Copeland, N.G. EMBO J. (2004) [Pubmed]
  33. Vascular endothelial growth factor C induces angiogenesis in vivo. Cao, Y., Linden, P., Farnebo, J., Cao, R., Eriksson, A., Kumar, V., Qi, J.H., Claesson-Welsh, L., Alitalo, K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  34. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. Calhoun, M.E., Burgermeister, P., Phinney, A.L., Stalder, M., Tolnay, M., Wiederhold, K.H., Abramowski, D., Sturchler-Pierrat, C., Sommer, B., Staufenbiel, M., Jucker, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  35. Localization of carbonic anhydrase IV in a specific capillary bed of the human eye. Hageman, G.S., Zhu, X.L., Waheed, A., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  36. Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor. Wolf, G., Ziyadeh, F.N., Thaiss, F., Tomaszewski, J., Caron, R.J., Wenzel, U., Zahner, G., Helmchen, U., Stahl, R.A. J. Clin. Invest. (1997) [Pubmed]
  37. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Rodriguez-Manzaneque, J.C., Lane, T.F., Ortega, M.A., Hynes, R.O., Lawler, J., Iruela-Arispe, M.L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  38. Effect of norepinephrine and fluid administration on pulmonary extravascular water volume in dogs. Ellis, J.H., Murray, J.F. Circ. Res. (1975) [Pubmed]
  39. Positron emission tomographic measurement of blood-to-brain and blood-to-tumor transport of 82Rb: the effect of dexamethasone and whole-brain radiation therapy. Jarden, J.O., Dhawan, V., Poltorak, A., Posner, J.B., Rottenberg, D.A. Ann. Neurol. (1985) [Pubmed]
  40. Absence of recipient CCR5 promotes early and increased allospecific antibody responses to cardiac allografts. Amano, H., Bickerstaff, A., Orosz, C.G., Novick, A.C., Toma, H., Fairchild, R.L. J. Immunol. (2005) [Pubmed]
WikiGenes - Universities