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MeSH Review


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Disease relevance of Ischemia

  • Oxygen-regulated protein 150 kD (ORP150) is a novel endoplasmic-reticulum-associated chaperone induced by hypoxia/ischemia [1].
  • However, u-PA-/- mice showed impaired scar formation and infarct revascularization, even after treatment with vascular endothelial growth factor, and died of cardiac failure due to depressed contractility, arrhythmias and ischemia [2].
  • The myofilament protein troponin I (TnI) has a key isoform-dependent role in the development of contractile failure during acidosis and ischemia [3].
  • Mice treated with this compound had little evidence of microvascular constriction and obstruction associated with myocarditis-induced ischemia reperfusion injury, much less inflammation and necrosis, only mild fibrosis and myocardial collagen deposition, and normal ventricular function, compared with the infected nontreated group [4].
  • L-Glutamate is a potent neurotoxin, and the inadequate clearance of excitatory amino acids may contribute to the neurodegeneration seen in a variety of conditions, including epilepsy, ischemia, and amyotrophic lateral sclerosis [5].

Psychiatry related information on Ischemia


High impact information on Ischemia


Chemical compound and disease context of Ischemia


Biological context of Ischemia


Anatomical context of Ischemia


Gene context of Ischemia


Analytical, diagnostic and therapeutic context of Ischemia


  1. ORP150 protects against hypoxia/ischemia-induced neuronal death. Tamatani, M., Matsuyama, T., Yamaguchi, A., Mitsuda, N., Tsukamoto, Y., Taniguchi, M., Che, Y.H., Ozawa, K., Hori, O., Nishimura, H., Yamashita, A., Okabe, M., Yanagi, H., Stern, D.M., Ogawa, S., Tohyama, M. Nat. Med. (2001) [Pubmed]
  2. Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Heymans, S., Luttun, A., Nuyens, D., Theilmeier, G., Creemers, E., Moons, L., Dyspersin, G.D., Cleutjens, J.P., Shipley, M., Angellilo, A., Levi, M., Nübe, O., Baker, A., Keshet, E., Lupu, F., Herbert, J.M., Smits, J.F., Shapiro, S.D., Baes, M., Borgers, M., Collen, D., Daemen, M.J., Carmeliet, P. Nat. Med. (1999) [Pubmed]
  3. Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Day, S.M., Westfall, M.V., Fomicheva, E.V., Hoyer, K., Yasuda, S., La Cross, N.C., D'Alecy, L.G., Ingwall, J.S., Metzger, J.M. Nat. Med. (2006) [Pubmed]
  4. A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis. Lee, J.K., Zaidi, S.H., Liu, P., Dawood, F., Cheah, A.Y., Wen, W.H., Saiki, Y., Rabinovitch, M. Nat. Med. (1998) [Pubmed]
  5. Excitatory amino acid transporters: a family in flux. Seal, R.P., Amara, S.G. Annu. Rev. Pharmacol. Toxicol. (1999) [Pubmed]
  6. Positron computed tomography for studies of myocardial and cerebral function. Phelps, M.E., Schelbert, H.R., Mazziotta, J.C. Ann. Intern. Med. (1983) [Pubmed]
  7. Endothelin-1 protects astrocytes from hypoxic/ischemic injury. Ho, M.C., Lo, A.C., Kurihara, H., Yu, A.C., Chung, S.S., Chung, S.K. FASEB J. (2001) [Pubmed]
  8. TGF-beta in the central nervous system: potential roles in ischemic injury and neurodegenerative diseases. Pratt, B.M., McPherson, J.M. Cytokine Growth Factor Rev. (1997) [Pubmed]
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  10. Hippocampal pyramidal cell loss in human status epilepticus. DeGiorgio, C.M., Tomiyasu, U., Gott, P.S., Treiman, D.M. Epilepsia (1992) [Pubmed]
  11. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Xiong, Z.G., Zhu, X.M., Chu, X.P., Minami, M., Hey, J., Wei, W.L., MacDonald, J.F., Wemmie, J.A., Price, M.P., Welsh, M.J., Simon, R.P. Cell (2004) [Pubmed]
  12. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Lambrechts, D., Storkebaum, E., Morimoto, M., Del-Favero, J., Desmet, F., Marklund, S.L., Wyns, S., Thijs, V., Andersson, J., van Marion, I., Al-Chalabi, A., Bornes, S., Musson, R., Hansen, V., Beckman, L., Adolfsson, R., Pall, H.S., Prats, H., Vermeire, S., Rutgeerts, P., Katayama, S., Awata, T., Leigh, N., Lang-Lazdunski, L., Dewerchin, M., Shaw, C., Moons, L., Vlietinck, R., Morrison, K.E., Robberecht, W., Van Broeckhoven, C., Collen, D., Andersen, P.M., Carmeliet, P. Nat. Genet. (2003) [Pubmed]
  13. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. Yusuf, S., Zhao, F., Mehta, S.R., Chrolavicius, S., Tognoni, G., Fox, K.K. N. Engl. J. Med. (2001) [Pubmed]
  14. Abnormal myocardial phosphorus-31 nuclear magnetic resonance spectroscopy in women with chest pain but normal coronary angiograms. Buchthal, S.D., den Hollander, J.A., Merz, C.N., Rogers, W.J., Pepine, C.J., Reichek, N., Sharaf, B.L., Reis, S., Kelsey, S.F., Pohost, G.M. N. Engl. J. Med. (2000) [Pubmed]
  15. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. Multicenter Study of Perioperative Ischemia Research Group. Mangano, D.T., Layug, E.L., Wallace, A., Tateo, I. N. Engl. J. Med. (1996) [Pubmed]
  16. Oxygen-derived free radicals in postischemic tissue injury. McCord, J.M. N. Engl. J. Med. (1985) [Pubmed]
  17. Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction. Borer, J.S., Redwood, D.R., Levitt, B., Cagin, N., Bianchi, C., Vallin, H., Epstein, S.E. N. Engl. J. Med. (1975) [Pubmed]
  18. Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. Robertson, R.M., Robertson, D., Roberts, L.J., Maas, R.L., FitzGerald, G.A., Friesinger, G.C., Oates, J.A. N. Engl. J. Med. (1981) [Pubmed]
  19. Platelet coagulant activities and serum lipids in transient cerebral ischemia. Walsh, P.N., Pareti, F.I., Corbett, J.J. N. Engl. J. Med. (1976) [Pubmed]
  20. Post-dopamine ischemia treated with chlorpromazine. Valdes, M.E. N. Engl. J. Med. (1976) [Pubmed]
  21. Early ischemia in growing piglet skeleton: MR diffusion and perfusion imaging. Menezes, N.M., Connolly, S.A., Shapiro, F., Olear, E.A., Jimenez, R.M., Zurakowski, D., Jaramillo, D. Radiology (2007) [Pubmed]
  22. Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury. Alderliesten, M., de Graauw, M., Oldenampsen, J., Qin, Y., Pont, C., van Buren, L., van de Water, B. Am. J. Pathol. (2007) [Pubmed]
  23. A randomized trial of exercise training in patients with coronary heart disease. Froelicher, V., Jensen, D., Genter, F., Sullivan, M., McKirnan, M.D., Witztum, K., Scharf, J., Strong, M.L., Ashburn, W. JAMA (1984) [Pubmed]
  24. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Wang, J., Liu, S., Fu, Y., Wang, J.H., Lu, Y. Nat. Neurosci. (2003) [Pubmed]
  25. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. Luedde, T., Assmus, U., Wüstefeld, T., Meyer zu Vilsendorf, A., Roskams, T., Schmidt-Supprian, M., Rajewsky, K., Brenner, D.A., Manns, M.P., Pasparakis, M., Trautwein, C. J. Clin. Invest. (2005) [Pubmed]
  26. Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Gao, J., Duan, B., Wang, D.G., Deng, X.H., Zhang, G.Y., Xu, L., Xu, T.L. Neuron (2005) [Pubmed]
  27. Oxygen-dependent lipid peroxidation during lung ischemia. Fisher, A.B., Dodia, C., Tan, Z.T., Ayene, I., Eckenhoff, R.G. J. Clin. Invest. (1991) [Pubmed]
  28. The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders. Pellegrini-Giampietro, D.E., Gorter, J.A., Bennett, M.V., Zukin, R.S. Trends Neurosci. (1997) [Pubmed]
  29. Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement. Weiser, M.R., Williams, J.P., Moore, F.D., Kobzik, L., Ma, M., Hechtman, H.B., Carroll, M.C. J. Exp. Med. (1996) [Pubmed]
  30. Chemokine expression during hepatic ischemia/reperfusion-induced lung injury in the rat. The role of epithelial neutrophil activating protein. Colletti, L.M., Kunkel, S.L., Walz, A., Burdick, M.D., Kunkel, R.G., Wilke, C.A., Strieter, R.M. J. Clin. Invest. (1995) [Pubmed]
  31. Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia. Timmons, J.A., Poucher, S.M., Constantin-Teodosiu, D., Worrall, V., Macdonald, I.A., Greenhaff, P.L. J. Clin. Invest. (1996) [Pubmed]
  32. Influence of methylprednisolone of the sequential redistribution of cathepsin D and other lysosomal enzymes during myocardial ischemia in rabbits. Decher, R.S., Poole, A.R., Dingle, J.T., Wildenthal, K. J. Clin. Invest. (1978) [Pubmed]
  33. Angiopoietin-1 protects the adult vasculature against plasma leakage. Thurston, G., Rudge, J.S., Ioffe, E., Zhou, H., Ross, L., Croll, S.D., Glazer, N., Holash, J., McDonald, D.M., Yancopoulos, G.D. Nat. Med. (2000) [Pubmed]
  34. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. Tsung, A., Sahai, R., Tanaka, H., Nakao, A., Fink, M.P., Lotze, M.T., Yang, H., Li, J., Tracey, K.J., Geller, D.A., Billiar, T.R. J. Exp. Med. (2005) [Pubmed]
  35. Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. Yepes, M., Sandkvist, M., Moore, E.G., Bugge, T.H., Strickland, D.K., Lawrence, D.A. J. Clin. Invest. (2003) [Pubmed]
  36. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. Nagoshi, T., Matsui, T., Aoyama, T., Leri, A., Anversa, P., Li, L., Ogawa, W., del Monte, F., Gwathmey, J.K., Grazette, L., Hemmings, B.A., Hemmings, B., Kass, D.A., Champion, H.C., Rosenzweig, A. J. Clin. Invest. (2005) [Pubmed]
  37. Expression of p21(WAF1/CIP1/SDI1) and p53 in apoptotic cells in the adrenal cortex and induction by ischemia/reperfusion injury. Didenko, V.V., Wang, X., Yang, L., Hornsby, P.J. J. Clin. Invest. (1996) [Pubmed]
  38. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Yan, S.F., Fujita, T., Lu, J., Okada, K., Shan Zou, Y., Mackman, N., Pinsky, D.J., Stern, D.M. Nat. Med. (2000) [Pubmed]
  39. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Heeschen, C., Jang, J.J., Weis, M., Pathak, A., Kaji, S., Hu, R.S., Tsao, P.S., Johnson, F.L., Cooke, J.P. Nat. Med. (2001) [Pubmed]
  40. The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Pola, R., Ling, L.E., Silver, M., Corbley, M.J., Kearney, M., Blake Pepinsky, R., Shapiro, R., Taylor, F.R., Baker, D.P., Asahara, T., Isner, J.M. Nat. Med. (2001) [Pubmed]
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  42. Cardiovascular effects of sildenafil during exercise in men with known or probable coronary artery disease: a randomized crossover trial. Arruda-Olson, A.M., Mahoney, D.W., Nehra, A., Leckel, M., Pellikka, P.A. JAMA (2002) [Pubmed]
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