Disease relevance of Blood Preservation

• The question of whether the metabolic product of adenine, 2,8-dioxyadenine was toxic to humans has apparently been resolved by extensive animal and human studies in favor of there being no potential toxicity in the amounts used in blood preservation [1].

High impact information on Blood Preservation

• The efficacy of whole blood preservation in acid citrate dextrose (ACD-A) and citrate-phosphate dextrose (CPD) anticoagulants containing half-strength trisodium citrate concentrations, was determined by biochemical and cellular assessment during 28 day storage at 4 degrees--6 degrees [2].
• Dihydroxyacetone, pyruvate, and phosphate effects on 2,3 DPG and ATP in citrate-phosphate-dextrose-adenine blood preservation [3].
• Adenine in blood preservation [4].
• Blood preservation 33. Phosphate enhancement of ribose maintenance of 2,3-DPG and ATP [5].
• Blood preservation 42: improvement of ascorbate's ability to maintain 2,3-DPG with inosine [6].

Anatomical context of Blood Preservation

• Blood preservation. XXVIII. Galactose and maltose maintain red blood cell 2,3-DPG and ATP [7].

Associations of Blood Preservation with chemical compounds

• Blood preservation XXVI, CPD-adenine packed cells: benefits of increasing the glucose [8].
• Blood preservation. XXIX. Pyruvate maintains normal red cell 2,3-DPG for six weeks of storage in CPD-adenine [9].
• Blood preservation. XLIII. Studies on the ascorbate mechanisms of maintaining red cell 2,3-DPG [10].
• Blood preservation XXVII. Fructose and mannose maintain ATP and 2,3-DPG [11].
• Blood preservation XLIV. 2,3-DPG maintenance by dehydroascorbate better than D-ascorbic acid [12].

Gene context of Blood Preservation

• Decrease in phosphofructokinase activity during blood preservation and the effect of intracellular ATP [13].
• We find that transport in non-infected cells, which is mediated by the specific saturable T system and the apparently non-saturable L system (Rosenberg, Young and Ellory (1980) Biochim. Biophys. Acta 598, 375-384) is considerably enhanced by blood preservation and culture conditions [14].

References