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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Endocytosis


Psychiatry related information on Endocytosis

  • Inhibition of endocytosis by cytochalasins B or D did not affect the chloroquine-sensitive breakdown of endogenous proteins, indicating that the proteins degraded by this process were truly endogenous and not taken in from the outside by cellular cannibalism [6].
  • Thus, constitutive endocytosis of anionic liposomes by LRP utilizes only one component, in contrast to the more involved heparan sulfate proteoglycan-LRP pathway implicated in the pathogenesis of Alzheimer's disease [7].
  • Although myosin-VI can be recruited to clathrin-coated pits, we find no requirement for myosin-VI motor activity in endocytosis in NRK cells [8].

High impact information on Endocytosis


Chemical compound and disease context of Endocytosis


Biological context of Endocytosis


Anatomical context of Endocytosis


Associations of Endocytosis with chemical compounds

  • Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis [29].
  • In some cases (Fc receptor, lysosomal glycoprotein Igp120), the determinant appears similar to that required for endocytosis via clathrin-coated pits; for Igp120, elimination of a single cytoplasmic domain tyrosine both blocks internalization and results in apical transport [30].
  • Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans [31].
  • A mutant receptor containing alanine instead of tyrosine residues at positions 24 and 26 was defective in endocytosis, and partially impaired in sorting [29].
  • However, we demonstrate here that some steroid hormones are taken up by receptor-mediated endocytosis of steroid-carrier complexes [32].

Gene context of Endocytosis

  • These observations demonstrate a role for SRC kinase in modification and recruitment of clathrin during ligand-induced EGFR endocytosis and thereby define a novel effector mechanism for regulation of endocytosis by receptor signaling [33].
  • We show that the low density lipoprotein (LDL) receptor-related protein (LRP) is responsible for the endocytosis of secreted APP [34].
  • Diferric Trf interacts with cell-surface Trf receptor (Trfr) to undergo receptor-mediated endocytosis into specialized endosomes [35].
  • Both planar transcytosis initiated by Dynamin-mediated endocytosis and extracellular diffusion have been proposed for Dpp movement across cells [31].
  • Dopamine acted through D2 dopamine receptors to induce endocytosis of VEGF receptor 2, which is critical for promoting angiogenesis, thereby preventing VPF/VEGF binding, receptor phosphorylation and subsequent signaling steps [36].

Analytical, diagnostic and therapeutic context of Endocytosis


  1. Epstein-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates adsorption, capping, and endocytosis. Tanner, J., Weis, J., Fearon, D., Whang, Y., Kieff, E. Cell (1987) [Pubmed]
  2. Myristic acid is coupled to a structural protein of polyoma virus and SV40. Streuli, C.H., Griffin, B.E. Nature (1987) [Pubmed]
  3. Regulation of plasma membrane recycling by CFTR. Bradbury, N.A., Jilling, T., Berta, G., Sorscher, E.J., Bridges, R.J., Kirk, K.L. Science (1992) [Pubmed]
  4. Luminal endocytosis and intracellular targeting by acinar cells during early biliary pancreatitis in the opossum. Lerch, M.M., Saluja, A.K., Rünzi, M., Dawra, R., Steer, M.L. J. Clin. Invest. (1995) [Pubmed]
  5. Calcium- and dynamin-independent endocytosis in dorsal root ganglion neurons. Zhang, C., Xiong, W., Zheng, H., Wang, L., Lu, B., Zhou, Z. Neuron (2004) [Pubmed]
  6. The effects of basic substances and acidic ionophores on the digestion of exogenous and endogenous proteins in mouse peritoneal macrophages. Ohkuma, S., Chudzik, J., Poole, B. J. Cell Biol. (1986) [Pubmed]
  7. Low-density lipoprotein receptor-related protein mediates the endocytosis of anionic liposomes in neurons. Lakkaraju, A., Rahman, Y.E., Dubinsky, J.M. J. Biol. Chem. (2002) [Pubmed]
  8. Regulation of myosin-VI targeting to endocytic compartments. Dance, A.L., Miller, M., Seragaki, S., Aryal, P., White, B., Aschenbrenner, L., Hasson, T. Traffic (2004) [Pubmed]
  9. Transepithelial transport of immunoglobulins. Mostov, K.E. Annu. Rev. Immunol. (1994) [Pubmed]
  10. Transport of cholesterol. Norum, K.R., Berg, T., Helgerud, P., Drevon, C.A. Physiol. Rev. (1983) [Pubmed]
  11. A slowed classical pathway rather than kiss-and-run mediates endocytosis at synapses lacking synaptojanin and endophilin. Dickman, D.K., Horne, J.A., Meinertzhagen, I.A., Schwarz, T.L. Cell (2005) [Pubmed]
  12. TTP specifically regulates the internalization of the transferrin receptor. Tosoni, D., Puri, C., Confalonieri, S., Salcini, A.E., De Camilli, P., Tacchetti, C., Di Fiore, P.P. Cell (2005) [Pubmed]
  13. A modular design for the clathrin- and actin-mediated endocytosis machinery. Kaksonen, M., Toret, C.P., Drubin, D.G. Cell (2005) [Pubmed]
  14. Evidence from lateral mobility studies for dynamic interactions of a mutant influenza hemagglutinin with coated pits. Fire, E., Zwart, D.E., Roth, M.G., Henis, Y.I. J. Cell Biol. (1991) [Pubmed]
  15. Two threshold values of low pH block endocytosis at different stages. Davoust, J., Gruenberg, J., Howell, K.E. EMBO J. (1987) [Pubmed]
  16. A Chinese hamster ovary cell mutant with a heat-sensitive, conditional-lethal defect in vacuolar function. Marnell, M.H., Mathis, L.S., Stookey, M., Shia, S.P., Stone, D.K., Draper, R.K. J. Cell Biol. (1984) [Pubmed]
  17. Amantadine and dansylcadaverine inhibit vesicular stomatitis virus uptake and receptor-mediated endocytosis of alpha 2-macroglobulin. Schlegel, R., Dickson, R.B., Willingham, M.C., Pastan, I.H. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  18. N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: association with NF-kappaB inhibition. Verhasselt, V., Vanden Berghe, W., Vanderheyde, N., Willems, F., Haegeman, G., Goldman, M. J. Immunol. (1999) [Pubmed]
  19. Primary amines inhibit recycling of alpha 2M receptors in fibroblasts. Van Leuven, F., Cassiman, J.J., Van Den Berghe, H. Cell (1980) [Pubmed]
  20. A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion. Courtois-Coutry, N., Roush, D., Rajendran, V., McCarthy, J.B., Geibel, J., Kashgarian, M., Caplan, M.J. Cell (1997) [Pubmed]
  21. A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Cao, T.T., Deacon, H.W., Reczek, D., Bretscher, A., von Zastrow, M. Nature (1999) [Pubmed]
  22. Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals. Robinson, P.J., Sontag, J.M., Liu, J.P., Fykse, E.M., Slaughter, C., McMahon, H., Südhof, T.C. Nature (1993) [Pubmed]
  23. Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis. Wadia, J.S., Stan, R.V., Dowdy, S.F. Nat. Med. (2004) [Pubmed]
  24. Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Ohtsubo, K., Takamatsu, S., Minowa, M.T., Yoshida, A., Takeuchi, M., Marth, J.D. Cell (2005) [Pubmed]
  25. Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts. Larkin, J.M., Brown, M.S., Goldstein, J.L., Anderson, R.G. Cell (1983) [Pubmed]
  26. A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis. Mao, Y., Chen, J., Maynard, J.A., Zhang, B., Quiocho, F.A. Cell (2001) [Pubmed]
  27. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Letourneur, F., Klausner, R.D. Cell (1992) [Pubmed]
  28. Dynamin undergoes a GTP-dependent conformational change causing vesiculation. Sweitzer, S.M., Hinshaw, J.E. Cell (1998) [Pubmed]
  29. Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endocytosis. Lobel, P., Fujimoto, K., Ye, R.D., Griffiths, G., Kornfeld, S. Cell (1989) [Pubmed]
  30. Basolateral sorting in MDCK cells requires a distinct cytoplasmic domain determinant. Hunziker, W., Harter, C., Matter, K., Mellman, I. Cell (1991) [Pubmed]
  31. Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans. Belenkaya, T.Y., Han, C., Yan, D., Opoka, R.J., Khodoun, M., Liu, H., Lin, X. Cell (2004) [Pubmed]
  32. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Nykjaer, A., Dragun, D., Walther, D., Vorum, H., Jacobsen, C., Herz, J., Melsen, F., Christensen, E.I., Willnow, T.E. Cell (1999) [Pubmed]
  33. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Wilde, A., Beattie, E.C., Lem, L., Riethof, D.A., Liu, S.H., Mobley, W.C., Soriano, P., Brodsky, F.M. Cell (1999) [Pubmed]
  34. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Kounnas, M.Z., Moir, R.D., Rebeck, G.W., Bush, A.I., Argraves, W.S., Tanzi, R.E., Hyman, B.T., Strickland, D.K. Cell (1995) [Pubmed]
  35. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Levy, J.E., Jin, O., Fujiwara, Y., Kuo, F., Andrews, N.C. Nat. Genet. (1999) [Pubmed]
  36. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Basu, S., Nagy, J.A., Pal, S., Vasile, E., Eckelhoefer, I.A., Bliss, V.S., Manseau, E.J., Dasgupta, P.S., Dvorak, H.F., Mukhopadhyay, D. Nat. Med. (2001) [Pubmed]
  37. Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies. Glenney, J.R., Chen, W.S., Lazar, C.S., Walton, G.M., Zokas, L.M., Rosenfeld, M.G., Gill, G.N. Cell (1988) [Pubmed]
  38. The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Kozyraki, R., Fyfe, J., Kristiansen, M., Gerdes, C., Jacobsen, C., Cui, S., Christensen, E.I., Aminoff, M., de la Chapelle, A., Krahe, R., Verroust, P.J., Moestrup, S.K. Nat. Med. (1999) [Pubmed]
  39. Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. Ezekowitz, R.A., Sastry, K., Bailly, P., Warner, A. J. Exp. Med. (1990) [Pubmed]
  40. Pancreatic acinar cell dysfunction in CFTR(-/-) mice is associated with impairments in luminal pH and endocytosis. Freedman, S.D., Kern, H.F., Scheele, G.A. Gastroenterology (2001) [Pubmed]
  41. Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction. Guichet, A., Wucherpfennig, T., Dudu, V., Etter, S., Wilsch-Bräuniger, M., Hellwig, A., González-Gaitán, M., Huttner, W.B., Schmidt, A.A. EMBO J. (2002) [Pubmed]
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