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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Administration, Oral

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Disease relevance of Administration, Oral


Psychiatry related information on Administration, Oral


High impact information on Administration, Oral


Chemical compound and disease context of Administration, Oral


Biological context of Administration, Oral


Anatomical context of Administration, Oral

  • These results indicate that oral administration of a thymic-dependent antigen (SRBC) to LPS-responsive mice induced a Ts cell population in PP, which, after migration to peripheral lymphoid tissue (e.g., spleen), suppressed responses to systemically administered antigen [26].
  • These results suggest that the oral administration of antigens generates antigen specific TGF-beta1 secreting Th3 cells of presumed mucosal origin that represent a distinct lineage of T cells [27].
  • These results indicated that increases in peripheral blood monocyte motility followed oral administration of levamisole [28].
  • The oral administration of 120,000 IU HMW-UK to human subjects for 7 d stimulated the synthesis of a UK-type protein of 53,000 mol wt, probably the zymogen, from either the liver or vascular endothelium, which was released into the circulation, and converted into active UK by circulating plasmin [29].
  • The CFA is destroyed by acid gastric contents but it induced significant antibody titer rises in 8 of 11 (73%) volunteers with preexisting serum anti-CFA IgG levels after oral administration of 1 mg of CFA/I with sodium bicarbonate [30].

Associations of Administration, Oral with chemical compounds

  • In Patient 1, at an ad libitum dietary sodium intake of about 300 mmol per day, oral administration of glutamine led to reproducible and marked anticystinuria and antiornithinuria, whereas the excretion of lysine and arginine was not significantly affected [31].
  • Thus, oral administration of levodopa to patients with severe heart failure produced a sustained improvement in cardiac function [32].
  • We conclude that oral administration of activated charcoal enhances the nonrenal clearance of phenobarbital [33].
  • Alterations of similar magnitude in the apparent plasma clearance of quinidine after oral administration (control 20.0 to 32.0 liters per hour; with anticonvulsant 44.0 to 94.0 liters per hour) suggest that this effect is probably due to an increase in the rate of metabolism of quinidine, although decreased absorption cannot be entirely ruled out [34].
  • Thromboxane B2 formation in serum ex vivo after oral administration of 20 mg of unlabeled aspirin was reduced 39 per cent before aspirin was detected in the systemic circulation [35].

Gene context of Administration, Oral


Analytical, diagnostic and therapeutic context of Administration, Oral


  1. Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Vazquez-Torres, A., Jones-Carson, J., Bäumler, A.J., Falkow, S., Valdivia, R., Brown, W., Le, M., Berggren, R., Parks, W.T., Fang, F.C. Nature (1999) [Pubmed]
  2. Induction of autoimmune diabetes by oral administration of autoantigen. Blanas, E., Carbone, F.R., Allison, J., Miller, J.F., Heath, W.R. Science (1996) [Pubmed]
  3. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. Aktas, O., Waiczies, S., Smorodchenko, A., Dorr, J., Seeger, B., Prozorovski, T., Sallach, S., Endres, M., Brocke, S., Nitsch, R., Zipp, F. J. Exp. Med. (2003) [Pubmed]
  4. N-nitrosodimethylamine blood levels in patients with chronic renal failure: modulation of levels by ethanol and ascorbic acid. Dunn, S.R., Simenhoff, M.L., Lele, P.S., Goyal, S., Pensabene, J.W., Fiddler, W. J. Natl. Cancer Inst. (1990) [Pubmed]
  5. Antineoplastic activity of cannabinoids. Munson, A.E., Harris, L.S., Friedman, M.A., Dewey, W.L., Carchman, R.A. J. Natl. Cancer Inst. (1975) [Pubmed]
  6. Stimulation of prolactin and growth hormone secretion by muscimol, a gamma-aminobutyric acid agonist. Tamminga, C.A., Neophytides, A., Chase, T.N., Frohman, L.A. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  7. Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Conney, A.H., Pantuck, E.J., Hsiao, K.C., Garland, W.A., Anderson, K.E., Alvares, A.P., Kappas, A. Clin. Pharmacol. Ther. (1976) [Pubmed]
  8. Sulpiride, a D2/D3 blocker, reduces cataplexy but not REM sleep in canine narcolepsy. Okura, M., Riehl, J., Mignot, E., Nishino, S. Neuropsychopharmacology (2000) [Pubmed]
  9. The effect on mechanical pain threshold over human muscles by oral administration of granisetron and diclofenac-sodium. Christidis, N., Kopp, S., Ernberg, M. Pain (2005) [Pubmed]
  10. Acute psychostimulant challenge in primary obsessive-compulsive disorder. Joffe, R.T., Swinson, R.P., Levitt, A.J. Journal of clinical psychopharmacology. (1991) [Pubmed]
  11. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Maeda, S., Kamata, H., Luo, J.L., Leffert, H., Karin, M. Cell (2005) [Pubmed]
  12. Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. Widén, E., Lehto, M., Kanninen, T., Walston, J., Shuldiner, A.R., Groop, L.C. N. Engl. J. Med. (1995) [Pubmed]
  13. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. el-Refaey, H., Rajasekar, D., Abdalla, M., Calder, L., Templeton, A. N. Engl. J. Med. (1995) [Pubmed]
  14. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group. DeFronzo, R.A., Goodman, A.M. N. Engl. J. Med. (1995) [Pubmed]
  15. A preliminary evaluation of 566C80 for the treatment of Pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome. Falloon, J., Kovacs, J., Hughes, W., O'Neill, D., Polis, M., Davey, R.T., Rogers, M., LaFon, S., Feuerstein, I., Lancaster, D. N. Engl. J. Med. (1991) [Pubmed]
  16. Interactions of natural effector cells and prostaglandins in the control of metastasis. Fulton, A.M. J. Natl. Cancer Inst. (1987) [Pubmed]
  17. Indomethacin-induced renal dysfunction in patients with well-compensated cirrhosis. Wong, F., Massie, D., Hsu, P., Dudley, F. Gastroenterology (1993) [Pubmed]
  18. Role of clostridial toxin in the pathogenesis of clindamycin colitis in rabbits. LaMont, J.T., Sonnenblick, E.B., Rothman, S. Gastroenterology (1979) [Pubmed]
  19. Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., Campieri, M. Gastroenterology (2000) [Pubmed]
  20. Effective and lasting growth-hormone suppression in active acromegaly with oral administration of somatostatin analogue SMS 201-995. Williams, G., Ball, J.A., Burrin, J.M., Joplin, G.F., Bloom, S.R. Lancet (1986) [Pubmed]
  21. Discovery of a peptide-based renin inhibitor with oral bioavailability and efficacy. Kleinert, H.D., Rosenberg, S.H., Baker, W.R., Stein, H.H., Klinghofer, V., Barlow, J., Spina, K., Polakowski, J., Kovar, P., Cohen, J. Science (1992) [Pubmed]
  22. Abnormal aminopyrine metabolism in patients with hepatic neoplasm. Detection by breath test. Hepner, G.W., Uhlin, S.R., Lipton, A., Harvey, H.A., Rohrer, V. JAMA (1976) [Pubmed]
  23. Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats. Gowen, M., Stroup, G.B., Dodds, R.A., James, I.E., Votta, B.J., Smith, B.R., Bhatnagar, P.K., Lago, A.M., Callahan, J.F., DelMar, E.G., Miller, M.A., Nemeth, E.F., Fox, J. J. Clin. Invest. (2000) [Pubmed]
  24. Sulfation and renal excretion of bile salts in patients with cirrhosis of the liver. Stiehl, A., Earnest, D.L., Admirant, W.H. Gastroenterology (1975) [Pubmed]
  25. Discrepancy between wedged hepatic venous pressure and portal venous pressure after acute propranolol administration in patients with alcoholic cirrhosis. Valla, D., Bercoff, E., Menu, Y., Bataille, C., Lebrec, D. Gastroenterology (1984) [Pubmed]
  26. Lack of oral tolerance in C3H/HeJ mice. Kiyono, H., McGhee, J.R., Wannemuehler, M.J., Michalek, S.M. J. Exp. Med. (1982) [Pubmed]
  27. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. Fukaura, H., Kent, S.C., Pietrusewicz, M.J., Khoury, S.J., Weiner, H.L., Hafler, D.A. J. Clin. Invest. (1996) [Pubmed]
  28. Acute effects of orally administered levamisole on random monocyte motility and chemotaxis in man. Nathanson, S.D., Zamfirescu, P.L., Portaro, J.K., deKernion, J.B., Fahey, J.L. J. Natl. Cancer Inst. (1978) [Pubmed]
  29. Transport of urokinase across the intestinal tract of normal human subjects with stimulation of synthesis and/or release of urokinase-type proteins. Toki, N., Sumi, H., Sasaki, K., Boreisha, I., Robbins, K.C. J. Clin. Invest. (1985) [Pubmed]
  30. Administration of purified colonization factor antigens (CFA/I, CFA/II) of enterotoxigenic Escherichia coli to volunteers. Response to challenge with virulent enterotoxigenic Escherichia coli. Evans, D.G., Graham, D.Y., Evans, D.J. Gastroenterology (1984) [Pubmed]
  31. Anticystinuric effects of glutamine and of dietary sodium restriction. Jaeger, P., Portmann, L., Saunders, A., Rosenberg, L.E., Thier, S.O. N. Engl. J. Med. (1986) [Pubmed]
  32. Beneficial hemodynamic effects of oral levodopa in heart failure. Relation to the generation of dopamine. Rajfer, S.I., Anton, A.H., Rossen, J.D., Goldberg, L.I. N. Engl. J. Med. (1984) [Pubmed]
  33. Acceleration of the body clearance of phenobarbital by oral activated charcoal. Berg, M.J., Berlinger, W.G., Goldberg, M.J., Spector, R., Johnson, G.F. N. Engl. J. Med. (1982) [Pubmed]
  34. Interaction of quinidine with anticonvulsant drugs. Data, J.L., Wilkinson, G.R., Nies, A.S. N. Engl. J. Med. (1976) [Pubmed]
  35. Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. Pedersen, A.K., FitzGerald, G.A. N. Engl. J. Med. (1984) [Pubmed]
  36. Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure. Smit, J.W., Huisman, M.T., van Tellingen, O., Wiltshire, H.R., Schinkel, A.H. J. Clin. Invest. (1999) [Pubmed]
  37. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. Tang, X., Kim, A.L., Feith, D.J., Pegg, A.E., Russo, J., Zhang, H., Aszterbaum, M., Kopelovich, L., Epstein, E.H., Bickers, D.R., Athar, M. J. Clin. Invest. (2004) [Pubmed]
  38. The endogenous cannabinoid system protects against colonic inflammation. Massa, F., Marsicano, G., Hermann, H., Cannich, A., Monory, K., Cravatt, B.F., Ferri, G.L., Sibaev, A., Storr, M., Lutz, B. J. Clin. Invest. (2004) [Pubmed]
  39. The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Leoni, F., Zaliani, A., Bertolini, G., Porro, G., Pagani, P., Pozzi, P., Donà, G., Fossati, G., Sozzani, S., Azam, T., Bufler, P., Fantuzzi, G., Goncharov, I., Kim, S.H., Pomerantz, B.J., Reznikov, L.L., Siegmund, B., Dinarello, C.A., Mascagni, P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  40. Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan). Teerlink, J.R., Löffler, B.M., Hess, P., Maire, J.P., Clozel, M., Clozel, J.P. Circulation (1994) [Pubmed]
  41. Influence of polyunsaturated fatty acids on survival of skin allografts and tumor incidence in mice. Mertin, J., Hunt, R. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  42. Coronary flow regulation in patients with ischemic heart disease: release of purines and prostacyclin and the effect of inhibitors of prostaglandin formation. Edlund, A., Berglund, B., van Dorne, D., Kaijser, L., Nowak, J., Patrono, C., Sollevi, A., Wennmalm, A. Circulation (1985) [Pubmed]
  43. Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Burger, H., van Tol, H., Boersma, A.W., Brok, M., Wiemer, E.A., Stoter, G., Nooter, K. Blood (2004) [Pubmed]
  44. The systemic administration of intravenous melphalan. Sarosy, G., Leyland-Jones, B., Soochan, P., Cheson, B.D. J. Clin. Oncol. (1988) [Pubmed]
  45. Glucose transport activity in insulin-resistant rat muscle. Effects of angiotensin-converting enzyme inhibitors and bradykinin antagonism. Henriksen, E.J., Jacob, S., Augustin, H.J., Dietze, G.J. Diabetes (1996) [Pubmed]
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