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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Morphogenesis

 
 
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Disease relevance of Morphogenesis

  • Rhizobium lipo-chitooligosaccharide nodulation factors: signaling molecules mediating recognition and morphogenesis [1].
  • The finding that ey of Drosophila, Small eye of the mouse, and human Aniridia are encoded by homologous genes suggests that eye morphogenesis is under similar genetic control in both vertebrates and insects, in spite of the large differences in eye morphology and mode of development [2].
  • Cell migration is essential for development, morphogenesis, tissue repair and tumor metastasis. p27(Kip1) and stathmin are two cell-cycle-regulatory proteins that were recently shown to play important roles in the regulation of cell migration [3].
  • Since homozygous Rae28-deficient (Rae28(-/-)) mice displayed cardiac anomalies similar to congenital heart diseases in humans, we examined the role of Rae28 in cardiac morphogenesis at the molecular level [4].
  • Finally, we show that the C. elegans INA-1 alpha integrin subunit associates with the PAT-3beta subunit in vivo, suggesting that these proteins function together in cell migration, axon fasciculation, and morphogenesis [5].
 

Psychiatry related information on Morphogenesis

 

High impact information on Morphogenesis

  • The identification of a glucose transporter gene responsible for altered arterial morphogenesis is notable in light of the previously suggested link between GLUT10 and type 2 diabetes [11].
  • Condensin/Cdc5-dependent removal of cohesin underscores the potential importance of crosstalk between chromosome structural components in chromosome morphogenesis and provides a mechanism to couple chromosome morphogenesis with other meiotic events [12].
  • Cell adhesion to extracellular matrix (ECM) proteins is crucial for the structural integrity of tissues and epithelial-mesenchymal interactions mediating organ morphogenesis [13].
  • A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis [14].
  • Loss or dysfunction of PC1 or PC2 may therefore lead to PKD owing to the inability of cells to sense mechanical cues that normally regulate tissue morphogenesis [15].
 

Chemical compound and disease context of Morphogenesis

 

Biological context of Morphogenesis

 

Anatomical context of Morphogenesis

 

Associations of Morphogenesis with chemical compounds

  • Mice with a mutation in the alpha8 gene do not express the integrin alpha8 beta1 and exhibit profound deficits in kidney morphogenesis [31].
  • The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans [32].
  • We propose that the ts-26 mutant has a primary temperature-sensitive defect in membrane glycoprotein synthesis and that this change causes pleiotropic effects on core morphogenesis [33].
  • Mutant strains of D. discoideum are described that can complete morphogenesis and cytodifferentiation but which express vastly reduced levels of the galactose-binding lectins discoidin I and II (less than 1% and 1%-2% respectively) compared to the wild-type control [34].
  • Thus, Shp2 regulates phosphotyrosine-signalling events during the complex ectodermal-mesenchymal interactions that regulate mammalian budding morphogenesis [35].
 

Gene context of Morphogenesis

  • Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis [36].
  • In addition, morphogenesis of Meckel's cartilage was deficient in cultured mandibular processes from Egfr-/- embryos [37].
  • Our data suggest that PKD1 and PKD2 associate physically in vivo and may be partners of a common signalling cascade involved in tubular morphogenesis [38].
  • Therefore, proximal-distal patterning of the ovule involves the regulated expression of the BEL1 gene that controls integument morphogenesis [39].
  • Here we show that Rom1-/- mice form OSs in which peripherin-2 homotetramers are localized to the disk rims, indicating that peripherin-2 alone is sufficient for both disk and OS morphogenesis [40].
 

Analytical, diagnostic and therapeutic context of Morphogenesis

References

  1. Rhizobium lipo-chitooligosaccharide nodulation factors: signaling molecules mediating recognition and morphogenesis. Dénarié, J., Debellé, F., Promé, J.C. Annu. Rev. Biochem. (1996) [Pubmed]
  2. Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans. Quiring, R., Walldorf, U., Kloter, U., Gehring, W.J. Science (1994) [Pubmed]
  3. p27(Kip1) and stathmin share the stage for the first time. Iancu-Rubin, C., Atweh, G.F. Trends Cell Biol. (2005) [Pubmed]
  4. The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis. Shirai, M., Osugi, T., Koga, H., Kaji, Y., Takimoto, E., Komuro, I., Hara, J., Miwa, T., Yamauchi-Takihara, K., Takihara, Y. J. Clin. Invest. (2002) [Pubmed]
  5. Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants. Baum, P.D., Garriga, G. Neuron (1997) [Pubmed]
  6. Altered proteoglycan synthesis by micromelial limbs induced by 6-aminonicotinamide. Appearance of abnormal forms of cartilage-characteristic proteoglycan (PG-H). Honda, A., Kazuno, S., Mori, Y., Kimata, K., Suzuki, S. Biochem. J. (1987) [Pubmed]
  7. Rho GTPases, dendritic structure, and mental retardation. Newey, S.E., Velamoor, V., Govek, E.E., Van Aelst, L. J. Neurobiol. (2005) [Pubmed]
  8. The morphogenesis of stereotyped behavior induced by the dopamine receptor agonist apomorphine in the laboratory rat. Szechtman, H., Ornstein, K., Teitelbaum, P., Golani, I. Neuroscience (1985) [Pubmed]
  9. The molecular basis of lung morphogenesis. Warburton, D., Schwarz, M., Tefft, D., Flores-Delgado, G., Anderson, K.D., Cardoso, W.V. Mech. Dev. (2000) [Pubmed]
  10. Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. Zcharia, E., Metzger, S., Chajek-Shaul, T., Aingorn, H., Elkin, M., Friedmann, Y., Weinstein, T., Li, J.P., Lindahl, U., Vlodavsky, I. FASEB J. (2004) [Pubmed]
  11. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. Coucke, P.J., Willaert, A., Wessels, M.W., Callewaert, B., Zoppi, N., De Backer, J., Fox, J.E., Mancini, G.M., Kambouris, M., Gardella, R., Facchetti, F., Willems, P.J., Forsyth, R., Dietz, H.C., Barlati, S., Colombi, M., Loeys, B., De Paepe, A. Nat. Genet. (2006) [Pubmed]
  12. Chromosome morphogenesis: condensin-dependent cohesin removal during meiosis. Yu, H.G., Koshland, D. Cell (2005) [Pubmed]
  13. A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Takamiya, K., Kostourou, V., Adams, S., Jadeja, S., Chalepakis, G., Scambler, P.J., Huganir, R.L., Adams, R.H. Nat. Genet. (2004) [Pubmed]
  14. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Chang, C.P., Neilson, J.R., Bayle, J.H., Gestwicki, J.E., Kuo, A., Stankunas, K., Graef, I.A., Crabtree, G.R. Cell (2004) [Pubmed]
  15. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nauli, S.M., Alenghat, F.J., Luo, Y., Williams, E., Vassilev, P., Li, X., Elia, A.E., Lu, W., Brown, E.M., Quinn, S.J., Ingber, D.E., Zhou, J. Nat. Genet. (2003) [Pubmed]
  16. Dynamic localization of a cytoplasmic signal transduction response regulator controls morphogenesis during the Caulobacter cell cycle. Jacobs, C., Hung, D., Shapiro, L. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  17. Electron microscopic observations on the morphogenesis of renal cell carcinoma induced in rat kidney by dimethylnitrosamine and N-(3,5-dichlorophenyl)succinimide. Sugihara, R., Sugihara, S. Cancer Res. (1976) [Pubmed]
  18. Pulmonary lesions induced by 3-methylindole in mice. Durham, S.K., Castleman, W.L. Am. J. Pathol. (1985) [Pubmed]
  19. Pulmonary endothelial and bronchiolar epithelial lesions induced by 4-ipomeanol in mice. Durham, S.K., Boyd, M.R., Castleman, W.L. Am. J. Pathol. (1985) [Pubmed]
  20. Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis. Onaka, H., Nakagawa, T., Horinouchi, S. Mol. Microbiol. (1998) [Pubmed]
  21. Arabidopsis LEAFY COTYLEDON1 is sufficient to induce embryo development in vegetative cells. Lotan, T., Ohto, M., Yee, K.M., West, M.A., Lo, R., Kwong, R.W., Yamagishi, K., Fischer, R.L., Goldberg, R.B., Harada, J.J. Cell (1998) [Pubmed]
  22. Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Satokata, I., Ma, L., Ohshima, H., Bei, M., Woo, I., Nishizawa, K., Maeda, T., Takano, Y., Uchiyama, M., Heaney, S., Peters, H., Tang, Z., Maxson, R., Maas, R. Nat. Genet. (2000) [Pubmed]
  23. Don't mess with the matrix. Vu, T.H. Nat. Genet. (2001) [Pubmed]
  24. Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila. McGinnis, W., Hart, C.P., Gehring, W.J., Ruddle, F.H. Cell (1984) [Pubmed]
  25. BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin. Yang, X.W., Wynder, C., Doughty, M.L., Heintz, N. Nat. Genet. (1999) [Pubmed]
  26. Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Batourina, E., Choi, C., Paragas, N., Bello, N., Hensle, T., Costantini, F.D., Schuchardt, A., Bacallao, R.L., Mendelsohn, C.L. Nat. Genet. (2002) [Pubmed]
  27. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Parviz, F., Matullo, C., Garrison, W.D., Savatski, L., Adamson, J.W., Ning, G., Kaestner, K.H., Rossi, J.M., Zaret, K.S., Duncan, S.A. Nat. Genet. (2003) [Pubmed]
  28. Mutations of the TWIST gene in the Saethre-Chotzen syndrome. el Ghouzzi, V., Le Merrer, M., Perrin-Schmitt, F., Lajeunie, E., Benit, P., Renier, D., Bourgeois, P., Bolcato-Bellemin, A.L., Munnich, A., Bonaventure, J. Nat. Genet. (1997) [Pubmed]
  29. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Montesano, R., Matsumoto, K., Nakamura, T., Orci, L. Cell (1991) [Pubmed]
  30. A common human skin tumour is caused by activating mutations in beta-catenin. Chan, E.F., Gat, U., McNiff, J.M., Fuchs, E. Nat. Genet. (1999) [Pubmed]
  31. Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Müller, U., Wang, D., Denda, S., Meneses, J.J., Pedersen, R.A., Reichardt, L.F. Cell (1997) [Pubmed]
  32. The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. George, S.E., Simokat, K., Hardin, J., Chisholm, A.D. Cell (1998) [Pubmed]
  33. A murine leukemia virus mutant with a temperature-sensitive defect in membrane glycoprotein synthesis. Ruta, M., Murray, M.J., Webb, M.C., Kabat, D. Cell (1979) [Pubmed]
  34. Mutants of Dictyostelium discoideum blocked in expression of all members of the developmentally regulated discoidin multigene family. Alexander, S., Shinnick, T.M., Lerner, R.A. Cell (1983) [Pubmed]
  35. The SH2 tyrosine phosphatase shp2 is required for mammalian limb development. Saxton, T.M., Ciruna, B.G., Holmyard, D., Kulkarni, S., Harpal, K., Rossant, J., Pawson, T. Nat. Genet. (2000) [Pubmed]
  36. Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis. Capovilla, M., Brandt, M., Botas, J. Cell (1994) [Pubmed]
  37. Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure. Miettinen, P.J., Chin, J.R., Shum, L., Slavkin, H.C., Shuler, C.F., Derynck, R., Werb, Z. Nat. Genet. (1999) [Pubmed]
  38. PKD1 interacts with PKD2 through a probable coiled-coil domain. Qian, F., Germino, F.J., Cai, Y., Zhang, X., Somlo, S., Germino, G.G. Nat. Genet. (1997) [Pubmed]
  39. The BELL1 gene encodes a homeodomain protein involved in pattern formation in the Arabidopsis ovule primordium. Reiser, L., Modrusan, Z., Margossian, L., Samach, A., Ohad, N., Haughn, G.W., Fischer, R.L. Cell (1995) [Pubmed]
  40. Rom-1 is required for rod photoreceptor viability and the regulation of disk morphogenesis. Clarke, G., Goldberg, A.F., Vidgen, D., Collins, L., Ploder, L., Schwarz, L., Molday, L.L., Rossant, J., Szél, A., Molday, R.S., Birch, D.G., McInnes, R.R. Nat. Genet. (2000) [Pubmed]
  41. Virus-induced diabetes mellitus: reovirus infection of pancreatic beta cells in mice. Onodera, T., Jenson, A.B., Yoon, J.W., Notkins, A.L. Science (1978) [Pubmed]
  42. An endothelial growth factor involved in rat renal development. Oliver, J.A., Al-Awqati, Q. J. Clin. Invest. (1998) [Pubmed]
  43. Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K.M., Birchmeier, C., Birchmeier, W. J. Cell Biol. (1995) [Pubmed]
  44. Cytoplasmic microtubules and fungal morphogenesis: ultrastructural effects of methyl benzimidazole-2-ylcarbamate determined by freeze-substitution of hyphal tip cells. Howard, R.J., Aist, J.R. J. Cell Biol. (1980) [Pubmed]
  45. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Reddi, A.H. Nat. Biotechnol. (1998) [Pubmed]
 
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