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MeSH Review

Cell Membrane

 
 
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Disease relevance of Cell Membrane

 

Psychiatry related information on Cell Membrane

 

High impact information on Cell Membrane

  • It is now clear that the plasma membrane does not represent the only platform for Ras/MAPK signaling [11].
  • The pathway by which Golgi-associated Ras becomes activated involves PLCgamma and RasGRP1 and may also require retrograde trafficking of Ras from the plasma membrane to the Golgi as a consequence of depalmitoylation [11].
  • A key organizing element for signaling receptors appears to be cholesterol- and sphingolipid-rich plasma membrane microdomains termed lipid rafts [12].
  • The polarized cell expresses the chemokine receptors at the leading cell edge, to which they are conveyed by rafts, a cholesterol-enriched membrane fraction fundamental to the lateral organization of the plasma membrane [13].
  • Investigations into the structure and function of FAAH, in combination with complementary studies of other AS enzymes, have engendered provocative molecular models to explain how this enzyme integrates into cell membranes and terminates fatty acid amide signaling in vivo [14].
 

Chemical compound and disease context of Cell Membrane

 

Biological context of Cell Membrane

 

Anatomical context of Cell Membrane

 

Associations of Cell Membrane with chemical compounds

 

Gene context of Cell Membrane

  • Most significant has been the identification of the plasma membrane protein TLR4 as the lipid A signaling receptor of animal cells [33].
  • AQP3 and AQP4 are both present in the basolateral plasma membrane of collecting duct principal cells and represent exit pathways for water reabsorbed apically via AQP2 [2].
  • The human MDR1 P-glycoprotein (Pgp) extrudes a variety of drugs across the plasma membrane [34].
  • In these mice, Dp71 was localized to the plasma membrane and restored normal levels of dystrophin associated proteins (DAPs), indicating that Dp71 is capable of interacting with the DAPs in a similar manner to dystrophin [35].
  • The Rh antigen is a multi-subunit complex composed of Rh polypeptides and associated glycoproteins (Rh50, CD47, LW and glycophorin B); these interact in the red cell membrane and are lacking or severely reduced in Rhnull cells [36].
 

Analytical, diagnostic and therapeutic context of Cell Membrane

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