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MeSH Review

Blastocyst

 
 
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Disease relevance of Blastocyst

 

Psychiatry related information on Blastocyst

 

High impact information on Blastocyst

  • In preimplantation embryos, Cdx2 is initially coexpressed with Oct3/4 and they form a complex for the reciprocal repression of their target genes in ES cells [9].
  • Nanog, a homeobox transcription factor, plays a crucial role in the second embryonic cell fate specification following formation of the blastocyst [10].
  • Here we show that null mutation of Trrap in mice results in peri-implantation lethality due to a blocked proliferation of blastocysts [11].
  • We disrupted the coding sequence of one allele of either Prm1 or Prm2 in embryonic stem (ES) cells derived from 129-strain mice, and injected them into blastocysts from C57BL/6-strain mice [12].
  • Oct4-deficient embryos develop to the blastocyst stage, but the inner cell mass cells are not pluripotent [13].
 

Chemical compound and disease context of Blastocyst

 

Biological context of Blastocyst

 

Anatomical context of Blastocyst

 

Associations of Blastocyst with chemical compounds

 

Gene context of Blastocyst

  • The earliest Xist expression in morulae and blastocysts is imprinted, resulting in specific expression of the paternal Xist allele [34].
  • In preimplantation embryos, Nanog is restricted to founder cells from which ES cells can be derived [35].
  • These results indicate a role for AbdB Hox genes in male and female fertility and suggest that maternal Hoxa10 is required to regulate the expression of a factor that affects the viability of preimplantation embryos [36].
  • Lymphocyte development and function was studied with the use of the RAG2-deficient blastocyst complementation system [37].
  • The closely linked H19 and Igf2 genes were activated after the blastocyst stage and often exhibited biallelic and monoallelic expression respectively in tissues of pregastrulation postimplantation-stage embryos, rather than reciprocal monoallelic modes as observed at later stages [38].
 

Analytical, diagnostic and therapeutic context of Blastocyst

References

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  23. Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos. Rappolee, D.A., Sturm, K.S., Behrendtsen, O., Schultz, G.A., Pedersen, R.A., Werb, Z. Genes Dev. (1992) [Pubmed]
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