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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Risk Factors

 
 
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Disease relevance of Risk Factors

  • After controlling for age and several coronary risk factors, we observed a lower risk of coronary disease among men with higher intakes of vitamin E (P for trend = 0.003) [1].
  • The effect was also apparently independent of known cardiovascular risk factors, including age, sex, blood pressure, blood cholesterol level, obesity, fasting blood glucose level, and cigarette smoking [2].
  • Breast cancer in men is rare--among the risk factors that have been identified are a family history of breast cancer and evidence of androgen insufficiency [3].
  • In the study population, whose blood pressure before and during treatment was in a narrow range, and after other cardiovascular risk factors had been considered, the renin profile before treatment remained independently associated with the subsequent risk of myocardial infarction [4].
  • METHODS: A total of 9297 high-risk patients (55 years of age or older) who had evidence of vascular disease or diabetes plus one other cardiovascular risk factor and who were not known to have a low ejection fraction or heart failure were randomly assigned to receive ramipril (10 mg once per day orally) or matching placebo for a mean of five years [5].
 

Psychiatry related information on Risk Factors

 

High impact information on Risk Factors

  • Subjecting arterial endothelial cells to classical atherosclerosis risk factors leads to the expression of HSP60 that then may serve as a target for pre-existent cross-reactive antimicrobial HSP60 immunity or bona fide autoimmune reactions induced by biochemically altered autologous HSP60 [11].
  • European Consensus Statement on Lung Cancer: risk factors and prevention. Lung Cancer Panel [12].
  • The primary disease-associated variant (rs2076530; P(TDT) = 3 x 10(-6), P(case-control) = 1.1 x 10(-8); replication P(TDT) = 0.0018, P(case-control) = 1.8 x 10(-6)) represents a risk factor that is independent of variation in HLA-DRB1 [13].
  • These results indicate that variants in the LTA are risk factors for myocardial infraction and implicate LTA in the pathogenesis of the disorder [14].
  • RESULTS: The 50 infants randomly assigned to fluconazole and the 50 control infants were similar in terms of birth weight, gestational age at birth, and base-line risk factors for fungal infection [15].
 

Chemical compound and disease context of Risk Factors

 

Biological context of Risk Factors

 

Anatomical context of Risk Factors

 

Associations of Risk Factors with chemical compounds

 

Gene context of Risk Factors

  • The E*4 allele of APOE is a major risk factor for AD regardless of age of onset or family history [33].
  • Matching [corrected] of HLA-C alleles was a significant risk factor for relapse of leukemia (P=0.035) [34].
  • Mismatching of HLA-A, but not of HLA-C, alleles was an independent risk factor for death (P<0.001) [34].
  • Hypothesizing that receptors for apoE-containing lipoproteins act as a potential risk factor for AD, we performed an association study using a polymorphic triplet (CGG) repeat in the gene for the VLDL receptor (VLDL-R), a receptor for apoE-containing lipoproteins [35].
  • We examined whether family history of breast cancer remains a predictive risk factor for this disease after carrier status for BRCA1 and/or BRCA2 mutations is taken into consideration [36].
 

Analytical, diagnostic and therapeutic context of Risk Factors

References

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  19. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. Selhub, J., Jacques, P.F., Bostom, A.G., D'Agostino, R.B., Wilson, P.W., Belanger, A.J., O'Leary, D.H., Wolf, P.A., Schaefer, E.J., Rosenberg, I.H. N. Engl. J. Med. (1995) [Pubmed]
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  23. Effect of risedronate on the risk of hip fracture in elderly women. Hip Intervention Program Study Group. McClung, M.R., Geusens, P., Miller, P.D., Zippel, H., Bensen, W.G., Roux, C., Adami, S., Fogelman, I., Diamond, T., Eastell, R., Meunier, P.J., Reginster, J.Y. N. Engl. J. Med. (2001) [Pubmed]
  24. Reduced graft rejection with good HLA-A and B matching in high-risk corneal transplantation. Sanfilippo, F., MacQueen, J.M., Vaughn, W.K., Foulks, G.N. N. Engl. J. Med. (1986) [Pubmed]
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