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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Longitudinal Studies

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Disease relevance of Longitudinal Studies


Psychiatry related information on Longitudinal Studies


High impact information on Longitudinal Studies

  • Cross-sectional population surveys have shown that HDL cholesterol is inversely related to plasma triglycerides, yet to our knowledge no longitudinal studies have shown that a decrease in elevated triglycerides will raise depressed HDL levels [11].
  • Few longitudinal studies have examined cocaine-exposed infants, however, and findings are contradictory because of methodologic limitations [12].
  • Longitudinal study will determine if glucose metabolic measures provide a means to monitor experimental treatment responses during the early phases of the disorder [13].
  • Long-term longitudinal studies are needed to determine the role of these two types of RFs in the pathogenesis of RA [14].
  • Cases and controls were taken from the longitudinal study of health in the Pima Indian population [15].

Chemical compound and disease context of Longitudinal Studies


Biological context of Longitudinal Studies


Anatomical context of Longitudinal Studies


Associations of Longitudinal Studies with chemical compounds

  • A longitudinal study was conducted in Sierra Leone to measure the impact of a single dose anthelminthic (400 mg albendazole) and daily iron-folate supplements (36 g iron and 5 mg folate) on haemoglobin (HG) concentration during pregnancy [31].
  • Evidence from randomized, controlled trials and from cross-sectional and longitudinal studies shows that estrogen-replacement therapy preferentially protects against a decline in verbal memory in healthy postmenopausal women and decreases the risk of AD [32].
  • A longitudinal study of workers involved in the manufacture of trimellitic anhydride has been in progress since 1977 [33].
  • We report similar findings in longitudinal studies of female Safari cats and demonstrate that the excessive skewing that develops with aging results from a third mechanism that has no pathologic consequence, hemizygous selection [34].
  • Longitudinal studies of three patients who received long term busulfan treatment did not show a significant change in the frequency of induced SCE [35].

Gene context of Longitudinal Studies


Analytical, diagnostic and therapeutic context of Longitudinal Studies


  1. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. Van Heek, M., Compton, D.S., France, C.F., Tedesco, R.P., Fawzi, A.B., Graziano, M.P., Sybertz, E.J., Strader, C.D., Davis, H.R. J. Clin. Invest. (1997) [Pubmed]
  2. HIV replication during the first weeks of life. Krivine, A., Firtion, G., Cao, L., Francoual, C., Henrion, R., Lebon, P. Lancet (1992) [Pubmed]
  3. Choline may be an essential nutrient in malnourished patients with cirrhosis. Chawla, R.K., Wolf, D.C., Kutner, M.H., Bonkovsky, H.L. Gastroenterology (1989) [Pubmed]
  4. Loss of circulating CD27+ memory B cells and CCR4+ T cells occurring in association with elevated EBV loads in XLP patients surviving primary EBV infection. Malbran, A., Belmonte, L., Ruibal-Ares, B., Baré, P., Massud, I., Parodi, C., Felippo, M., Hodinka, R., Haines, K., Nichols, K.E., de Bracco, M.M. Blood (2004) [Pubmed]
  5. Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific. Fox, J.G., Rogers, A.B., Ihrig, M., Taylor, N.S., Whary, M.T., Dockray, G., Varro, A., Wang, T.C. Cancer Res. (2003) [Pubmed]
  6. Primary affective disorder, clinical state change, and MHPG excretion: a longitudinal study. Pickar, D., Sweeney, D.R., Maas, J.W., Heninger, G.R. Arch. Gen. Psychiatry (1978) [Pubmed]
  7. Accelerated hippocampal atrophy in Alzheimer's disease with apolipoprotein E epsilon4 allele. Mori, E., Lee, K., Yasuda, M., Hashimoto, M., Kazui, H., Hirono, N., Matsui, M. Ann. Neurol. (2002) [Pubmed]
  8. Visuospatial deficit in dementia of the Alzheimer type. Kaskie, B., Storandt, M. Arch. Neurol. (1995) [Pubmed]
  9. The relationship between polycystic ovary syndrome and antiepileptic drugs: a review of the evidence. Rasgon, N. Journal of clinical psychopharmacology. (2004) [Pubmed]
  10. Relationship between drug abuse and intimate partner violence: a longitudinal study among women receiving methadone. El-Bassel, N., Gilbert, L., Wu, E., Go, H., Hill, J. American journal of public health. (2005) [Pubmed]
  11. Normalization on triglycerides in type IV hyperlipoproteinemia fails to correct low levels of high-density-lipoprotein cholesterol. Witztum, J.L., Dillingham, M.A., Giese, W., Bateman, J., Diekman, C., Blaufuss, E.K., Weidman, S., Schonfeld, G. N. Engl. J. Med. (1980) [Pubmed]
  12. Cognitive and motor outcomes of cocaine-exposed infants. Singer, L.T., Arendt, R., Minnes, S., Farkas, K., Salvator, A., Kirchner, H.L., Kliegman, R. JAMA (2002) [Pubmed]
  13. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. Small, G.W., Mazziotta, J.C., Collins, M.T., Baxter, L.R., Phelps, M.E., Mandelkern, M.A., Kaplan, A., La Rue, A., Adamson, C.F., Chang, L. JAMA (1995) [Pubmed]
  14. Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis. Burastero, S.E., Casali, P., Wilder, R.L., Notkins, A.L. J. Exp. Med. (1988) [Pubmed]
  15. Adiponectin and development of type 2 diabetes in the Pima Indian population. Lindsay, R.S., Funahashi, T., Hanson, R.L., Matsuzawa, Y., Tanaka, S., Tataranni, P.A., Knowler, W.C., Krakoff, J. Lancet (2002) [Pubmed]
  16. Fasting serum sulfate levels before and after development of osteoarthritis in participants of the veterans administration normative aging longitudinal study do not differ from levels in participants in whom osteoarthritis did not develop. Blinn, C.M., Dibbs, E.R., Hronowski, L.J., Vokonas, P.S., Silbert, J.E. Arthritis Rheum. (2005) [Pubmed]
  17. A multi-centre longitudinal study comparing the sensitivity of monthly MRI after standard and triple dose gadolinium-DTPA for monitoring disease activity in multiple sclerosis. Implications for phase II clinical trials. Filippi, M., Rovaris, M., Capra, R., Gasperini, C., Yousry, T.A., Sormani, M.P., Prandini, F., Horsfield, M.A., Martinelli, V., Bastianello, S., Kühne, I., Pozzilli, C., Comi, G. Brain (1998) [Pubmed]
  18. Insulin and glucose excursion following premeal insulin lispro or repaglinide in cystic fibrosis-related diabetes. Moran, A., Phillips, J., Milla, C. Diabetes Care (2001) [Pubmed]
  19. Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging. Baldereschi, M., Di Carlo, A., Lepore, V., Bracco, L., Maggi, S., Grigoletto, F., Scarlato, G., Amaducci, L. Neurology (1998) [Pubmed]
  20. The longitudinal study of adrenal maturation during gonadal suppression: evidence that adrenarche is a gradual process. Palmert, M.R., Hayden, D.L., Mansfield, M.J., Crigler, J.F., Crowley, W.F., Chandler, D.W., Boepple, P.A. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  21. Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study. Sears, M.R., Greene, J.M., Willan, A.R., Taylor, D.R., Flannery, E.M., Cowan, J.O., Herbison, G.P., Poulton, R. Lancet (2002) [Pubmed]
  22. Effects of diet and sexual maturation on low-density lipoprotein cholesterol during puberty: the Dietary Intervention Study in Children (DISC). Kwiterovich, P.O., Barton, B.A., McMahon, R.P., Obarzanek, E., Hunsberger, S., Simons-Morton, D., Kimm, S.Y., Friedman, L.A., Lasser, N., Robson, A., Lauer, R., Stevens, V., Van Horn, L., Gidding, S., Snetselaar, L., Hartmuller, V.W., Greenlick, M., Franklin, F. Circulation (1997) [Pubmed]
  23. Longitudinal study of hand bone densitometry in rheumatoid arthritis. Deodhar, A.A., Brabyn, J., Jones, P.W., Davis, M.J., Woolf, A.D. Arthritis Rheum. (1995) [Pubmed]
  24. Ambulatory blood pressure in the transition from normo- to microalbuminuria. A longitudinal study in IDDM patients. Poulsen, P.L., Hansen, K.W., Mogensen, C.E. Diabetes (1994) [Pubmed]
  25. Preterm birth and later insulin resistance: effects of birth weight and postnatal growth in a population based longitudinal study from birth into adult life Insulin resistance 19 years after preterm birth. Finken, M.J., Keijzer-Veen, M.G., Dekker, F.W., Frölich, M., Hille, E.T., Romijn, J.A., Wit, J.M. Diabetologia (2006) [Pubmed]
  26. The effect of thyroid hormone on skeletal integrity. Greenspan, S.L., Greenspan, F.S. Ann. Intern. Med. (1999) [Pubmed]
  27. Quantitative neuropathology and quantitative magnetic resonance imaging of the hippocampus in temporal lobe epilepsy. Van Paesschen, W., Revesz, T., Duncan, J.S., King, M.D., Connelly, A. Ann. Neurol. (1997) [Pubmed]
  28. Detection of blood-borne cells in colorectal cancer patients by nested reverse transcription-polymerase chain reaction for carcinoembryonic antigen messenger RNA: longitudinal analyses and demonstration of its potential importance as an adjunct to multiple serum markers. Guadagni, F., Kantor, J., Aloe, S., Carone, M.D., Spila, A., D'Alessandro, R., Abbolito, M.R., Cosimelli, M., Graziano, F., Carboni, F., Carlini, S., Perri, P., Sciarretta, F., Greiner, J.W., Kashmiri, S.V., Steinberg, S.M., Roselli, M., Schlom, J. Cancer Res. (2001) [Pubmed]
  29. Longitudinal study of central motor conduction time following stroke. 1. Natural history of central motor conduction. Heald, A., Bates, D., Cartlidge, N.E., French, J.M., Miller, S. Brain (1993) [Pubmed]
  30. The natural history of lymphocyte subsets infiltrating the pancreas of NOD mice. Signore, A., Pozzilli, P., Gale, E.A., Andreani, D., Beverley, P.C. Diabetologia (1989) [Pubmed]
  31. Anthelminthic treatment and haemoglobin concentrations during pregnancy. Torlesse, H., Hodges, M. Lancet (2000) [Pubmed]
  32. Estrogen and cognitive aging in women. Sherwin, B.B. Trends Pharmacol. Sci. (2002) [Pubmed]
  33. Syndromes in workers exposed to trimellitic anhydride. A longitudinal clinical and immunologic study. Zeiss, C.R., Wolkonsky, P., Chacon, R., Tuntland, P.A., Levitz, D., Prunzansky, J.J., Patterson, R. Ann. Intern. Med. (1983) [Pubmed]
  34. An X chromosome gene regulates hematopoietic stem cell kinetics. Abkowitz, J.L., Taboada, M., Shelton, G.H., Catlin, S.N., Guttorp, P., Kiklevich, J.V. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  35. Induction of sister chromatid exchanges and chromosomal aberrations by busulfan in Philadelphia chromosome-positive chronic myeloid leukemia and normal bone marrow. Becher, R., Prescher, G. Cancer Res. (1988) [Pubmed]
  36. Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia. Pastore, Y., Jedlickova, K., Guan, Y., Liu, E., Fahner, J., Hasle, H., Prchal, J.F., Prchal, J.T. Am. J. Hum. Genet. (2003) [Pubmed]
  37. Patterns of CDKN2A gene loss in sequential oral epithelial dysplasias and carcinomas. Shahnavaz, S.A., Bradley, G., Regezi, J.A., Thakker, N., Gao, L., Hogg, D., Jordan, R.C. Cancer Res. (2001) [Pubmed]
  38. Urinary VEGF and MMP levels as predictive markers of 1-year progression-free survival in cancer patients treated with radiation therapy: a longitudinal study of protein kinetics throughout tumor progression and therapy. Chan, L.W., Moses, M.A., Goley, E., Sproull, M., Muanza, T., Coleman, C.N., Figg, W.D., Albert, P.S., Ménard, C., Camphausen, K. J. Clin. Oncol. (2004) [Pubmed]
  39. Immunohistochemical staining for markers of future neoplastic progression in the larynx. Uhlman, D.L., Adams, G., Knapp, D., Aeppli, D.M., Niehans, G. Cancer Res. (1996) [Pubmed]
  40. Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population. Payton, A., Holland, F., Diggle, P., Rabbitt, P., Horan, M., Davidson, Y., Gibbons, L., Worthington, J., Ollier, W.E., Pendleton, N. Mol. Psychiatry (2003) [Pubmed]
  41. The work dynamics of the person with rheumatoid arthritis. Yelin, E., Henke, C., Epstein, W. Arthritis Rheum. (1987) [Pubmed]
  42. Documenting damage progression in a two-year longitudinal study of rheumatoid arthritis patients with established disease (the DAMAGE study cohort): is there an advantage in the use of magnetic resonance imaging as compared with plain radiography? Bird, P., Kirkham, B., Portek, I., Shnier, R., Joshua, F., Edmonds, J., Lassere, M. Arthritis Rheum. (2004) [Pubmed]
  43. Gastric parietal cell and other autoantibodies in the BB rat. Elder, M., Maclaren, N., Riley, W., McConnell, T. Diabetes (1982) [Pubmed]
  44. A longitudinal study of high and low avidity antibodies to double-stranded DNA in systemic lupus erythematosus. McGrath, H., Biundo, J.J. Arthritis Rheum. (1985) [Pubmed]
  45. Glucose metabolism in the first 3 years after renal transplantation in patients receiving tacrolimus versus cyclosporine-based immunosuppression. van Duijnhoven, E.M., Christiaans, M.H., Boots, J.M., Nieman, F.H., Wolffenbuttel, B.H., van Hooff, J.P. J. Am. Soc. Nephrol. (2002) [Pubmed]
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