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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Binding Sites

 
 
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Disease relevance of Binding Sites

 

Psychiatry related information on Binding Sites

 

High impact information on Binding Sites

  • This suggests a model of the RAG protein active site in which two divalent metal ions serve alternating and opposite roles as activators of attacking hydroxyl groups and stabilizers of oxyanion leaving groups [11].
  • TRX is a small multifunctional protein that has a redox-active disulfide/dithiol within the conserved active site sequence: Cys-Gly-Pro-Cys [12].
  • The degenerate binding indicated that the binding site of MHC proteins must have a significant number of conserved features [13].
  • These binding sites are insensitive to the effects of guanine nucleotides and appear to be rapidly internalized [14].
  • Prolyl hydroxylation generates a binding site for a ubiquitin ligase complex containing the von Hippel-Lindau (VHL) tumor suppressor protein, which results in HIFalpha destruction [15].
 

Chemical compound and disease context of Binding Sites

 

Biological context of Binding Sites

 

Anatomical context of Binding Sites

 

Associations of Binding Sites with chemical compounds

 

Gene context of Binding Sites

  • The CETP contains binding sites for cholesteryl ester and triglycerides and probably acts by a carrier-mediated mechanism [36].
  • Our results suggest that RAP1 may be a transcriptional regulator that can play a role in either repression or activation of transcription, depending upon the context of its binding site [37].
  • Mutation of the active site of caspase-9 attenuated the activation of caspase-3 and cellular apoptotic response in vivo, indicating that caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP [38].
  • Stimulation depended upon GAL4 binding sites inserted in the template [39].
  • Highly conserved FGF-D2 and FGF-linker (between D2-D3) interfaces define a general binding site for all FGF-FGFR complexes [40].
 

Analytical, diagnostic and therapeutic context of Binding Sites

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