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MeSH Review

Mechanoreceptors

 
 
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Disease relevance of Mechanoreceptors

 

Psychiatry related information on Mechanoreceptors

  • The aim of the present study was to test the hypothesis that afferent mechanoreceptor stimuli from the respiratory muscles contribute to the arousal response to CO2 from both non-rapid-eye-movement (NREM) and rapid-eye-movement (REM) sleep [6].
  • These results indicated that the individuals evaluated in this study with ACL injury and good functional and muscular performance did not have proprioceptive deficits, suggesting that the ligament mechanoreceptors, in some cases, might not contribute relevantly to proprioception [7].
 

High impact information on Mechanoreceptors

  • In D. melanogaster, a common proneural gene called atonal (ato) functions in the initial process of development of a number of segment-specific organs, including the compound eye, the auditory organ and the stretch receptor, suggesting that these organs share an evolutionary origin [8].
  • Here we show that disrupting the mouse BNC1 gene markedly reduces the sensitivity of a specific component of mechanosensation: low-threshold rapidly adapting mechanoreceptors [9].
  • Stretch receptors had currents that differed from those of P2X3 channels, and had no P2X3 immunoreactivity [10].
  • Using electrophysiology in BDNF-deficient mice, we show here that slowly adapting mechanoreceptors (SAM), but not other types of cutaneous afferents, require BDNF in postnatal life for normal mechanotransduction [11].
  • Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation [12].
 

Chemical compound and disease context of Mechanoreceptors

 

Biological context of Mechanoreceptors

 

Anatomical context of Mechanoreceptors

 

Associations of Mechanoreceptors with chemical compounds

  • Because TLESRs are considered to be triggered by activation of gastric mechanoreceptors, and because the gamma-aminobutyric acid type B (GABA(B))-receptor agonist baclofen is known to inhibit transmitter release from mechanosensitive afferents, the effects of baclofen on TLESRs in the dog were assessed [25].
  • The gastric phase can be generated by mechanoreceptors utilizing the cholinergic pathways, whereas the intestinal phase is nutrient-specific, partially atropine-sensitive, and independent of cholecystokinin [26].
  • To determine whether or not the digitalis-induced sympathoinhibition in the heart failure patients was simply due to an inotropic effect (stimulation of inhibitory cardiac mechanoreceptors), we studied the responses of seven additional patients with heart failure before and during administration of dobutamine (3.4 +/- 0.4 micrograms/kg/min) [27].
  • The same experiments were repeated after administration of propranolol (0.15 mg/kg i.v.), which is thought to decrease ventricular mechanoreceptor discharge [28].
  • To abolish the effect of rapidly adapting receptors, we used inhaled bupivacaine aerosol, and to abolish the effect of slowly adapting stretch receptor activity, we used sulfur dioxide insufflation [29].
 

Gene context of Mechanoreceptors

  • The results are consistent with the model that precursor cells intended to become BDNF-dependent mechanoreceptors instead differentiate into NT-3-dependent proprioceptive neurons [30].
  • Previous studies have shown that BDNF is required for the mechanical sensitivity of slowly adapting (SA) mechanoreceptors but not for the postnatal survival of myelinated cutaneous afferent fibers [31].
  • In contrast, the receptive properties of SA mechanoreceptors were not impaired in animals lacking NT4 [31].
  • Conversely, ectopic expression of ceh-17 in the mechanoreceptors, several of which are known to pioneer their tract, leads to exaggerated longitudinal axonal outgrowth [32].
  • This suggests that PECAM-1 may not function as a major mechanoreceptor for activation of MAPK and AKT in ECs and that there are likely to be other mechanoreceptors in ECs functioning to detect shear stress and trigger intercellular signals [33].
 

Analytical, diagnostic and therapeutic context of Mechanoreceptors

References

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  18. Effects of aerosol-applied capsaicin, histamine and prostaglandin E2 on airway sensory receptors of anaesthetized cats. Mohammed, S.P., Higenbottam, T.W., Adcock, J.J. J. Physiol. (Lond.) (1993) [Pubmed]
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