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MeSH Review

Lung Compliance

 
 
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Disease relevance of Lung Compliance

 

High impact information on Lung Compliance

  • Samples exposed to FeCl2 + H2O2 had significantly diminished surface tension lowering ability in vivo as indicated by their reduced ability to improve lung compliance of surfactant-deficient fetal rabbits [6].
  • Lung compliance, pulmonary function, surfactant pool size, glucose and FFA levels were significantly decreased in adrenalectomized animals [7].
  • Complete deficiency of SP-B in mice and humans results in lethal, neonatal respiratory distress syndrome and is characterized by a virtual absence of lung compliance, highly disorganized lamellar bodies, and greatly diminished levels of SP-C mature peptide; in contrast, lung structure and function in SP-C null mice is normal [8].
  • Lung morphology, surfactant proteins B-D, lung tissue, alveolar phospholipid pool sizes and composition, and lung compliance in SP-A(-/-) mice were unaltered [9].
  • Eighteen patients with progressive pulmonary dysfunction, diminished vital capacity (VC), and/or decreased static lung compliance (Cst) were treated with cyclophosphamide and corticosteroids for 1 year [10].
 

Chemical compound and disease context of Lung Compliance

  • The data show that conventional doses of furosemide can (1) cause metabolic alkalosis and reduce ventilation; (2) increase the PaCO2, which reflects changes in acid-base status and not changes in lung function; and (3) increase lung compliance, perhaps by decreasing lung water [11].
  • Our data show that alpha 1-AT treatment prevented the reduced lung compliance observed in the untreated hyperoxia-exposed neonatal rats, as well as the right ventricular hypertrophy and the associated vascular changes of medial hypertrophy of muscular arteries and muscularization of distal arteries [12].
  • The relative activities of three bronchoconstrictive mediators of anaphylaxis, prostaglandin (PG) D2, PGF2 alpha and histamine, were investigated in anesthetized dogs using two different measures of peripheral lung reactivity: resistance to flow through collateral airways (Rcoll) and dynamic lung compliance (Cdyn) [13].
  • 4 These results may suggest that TXA2 is responsible for the endotoxin-induced pulmonary arterial hypertension but that some other arachidonic acid derivative (prostaglandin F2 alpha) is responsible for the reduced lung compliance that follows the acute administration of E. coli endotoxin [14].
  • Therefore, we measured EELV, total lung resistance (RL), dynamic lung compliance (Cdyn), DE, and minute ventilation (VE) in anesthetized rats during normoxia and hypoxia (10% O(2)) before (control) and after administration of atropine or saline [15].
 

Biological context of Lung Compliance

 

Anatomical context of Lung Compliance

  • During the study, percent change from baseline of peak airway pressure, total lung compliance of the lung and chest wall, and blood lactate levels appeared to be significantly smaller in dogs pretreated with CoQ10 than in controls [21].
  • RESULTS: Endotoxin caused decreases in peripheral leukocyte counts, lung compliance, and arterial oxygen tension, and increases in the lung wet-to dry-weight ratio, polymorphonuclear cell counts in BALF, and albumin, C3a, C5a, tumor necrosis factor alpha, interleukin-1 beta, and thromboxane B2 concentrations in BALF [22].
  • Stimulation of pulmonary C-fibers (PCs) by capsaicin and of rapidly adapting receptors (RARs) by reduced lung compliance reflexly increases airway submucosal gland secretion in dogs [23].
  • In this genetic mouse model of obesity, the results suggested that respiratory complications associated with the obese phenotype, including rapid breathing pattern at baseline, diminished lung compliance, and abnormal respiratory muscle adaptations, are attenuated with prolonged leptin treatment [24].
  • Effects of atropine on the responses of rapidly adapting pulmonary stretch receptors and dynamic lung compliance to sodium cyanide-induced hyperpnea [25].
 

Associations of Lung Compliance with chemical compounds

 

Gene context of Lung Compliance

 

Analytical, diagnostic and therapeutic context of Lung Compliance

References

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  21. Effects of coenzyme Q10 in hemorrhagic shock. Yamada, M. Crit. Care Med. (1990) [Pubmed]
  22. Effect of lidocaine pretreatment on endotoxin-induced lung injury in rabbits. Mikawa, K., Maekawa, N., Nishina, K., Takao, Y., Yaku, H., Obara, H. Anesthesiology (1994) [Pubmed]
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  24. Leptin attenuates respiratory complications associated with the obese phenotype. Tankersley, C.G., O'Donnell, C., Daood, M.J., Watchko, J.F., Mitzner, W., Schwartz, A., Smith, P. J. Appl. Physiol. (1998) [Pubmed]
  25. Effects of atropine on the responses of rapidly adapting pulmonary stretch receptors and dynamic lung compliance to sodium cyanide-induced hyperpnea. Matsumoto, S., Yamasaki, M., Nagayama, T., Kanno, T., Shimizu, T. J. Auton. Nerv. Syst. (1993) [Pubmed]
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