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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Chromatography, Liquid

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Disease relevance of Chromatography, Liquid

  • Its identity was confirmed by three independent techniques: (i) by measuring the retention times on two different high-performance liquid-chromatography columns, (ii) by dehydration to N-nitrosomorpholine, and (iii) by preparation of the O-methyl ether derivative [1].
  • High-performance liquid chromatography showed lower levels of dopamine in the muscularis externa (but not mucosa) in four Parkinson's disease patients than in four controls (7.3 [5.1] vs 24.2 [4.6] nmol per g protein), but levels of dopamine metabolites were similar in the two groups [2].
  • To ascertain whether or not such an association is present, we measured the serum concentration of retinol with high performance liquid chromatography, and correlated the results with concurrent quantified HIV-1 RNA concentrations in cervicovaginal lavage fluid in 301 women infected with the virus [3].
  • Myocardial blood flow was assessed by a well counter, correlated with the extent of fibrosis expressed as collagen per total tissue proteins obtained from 4-hydroxyproline and glycine as determined by high-performance liquid chromatography [4].
  • We have isolated and characterized modified TnI products in isolated rat hearts after 0, 15, or 60 minutes of ischemia followed by 45 minutes of reperfusion using affinity chromatography with cardiac troponin C (TnC) and an anti-TnI antibody, immunological mapping, reversed-phase high-performance liquid chromatography, and mass spectrometry [5].

Psychiatry related information on Chromatography, Liquid


High impact information on Chromatography, Liquid


Chemical compound and disease context of Chromatography, Liquid


Biological context of Chromatography, Liquid


Anatomical context of Chromatography, Liquid


Associations of Chromatography, Liquid with chemical compounds

  • We found, using high-pressure liquid chromatography (HPLC), that both techniques produced a substantial reduction in the level of cortical NA [31].
  • Radiolabeled all-trans retinol and high-performance liquid chromatography have now been used to demonstrate the existence of an eye-specific, membrane-bound enzyme (retinol isomerase) that converts all-trans to 11-cis retinol in the dark [32].
  • Trace amounts of glycine, serine, and alanine were detected in the carbonate component of the martian meteorite ALH84001 by high-performance liquid chromatography [33].
  • Fractions from ethanol extracts of the Walker 256 carcinoma were isolated by silica column chromatography and C18 reversed-phase high-performance liquid chromatography [34].
  • These effects may be due in part to the action of leukotrienes D4 and C4, which were identified by bioassay and high-pressure liquid chromatography in the lung effluent after stimulation by platelet-activating factor [35].

Gene context of Chromatography, Liquid


Analytical, diagnostic and therapeutic context of Chromatography, Liquid


  1. N-Nitrosodiethanolamine in synthetic cutting fluids: a part-per-hundred impurity. Fan, T.Y., Morrison, J., Rounbehler, D.P., Ross, R., Fine, D.H., Miles, W., Sen, N.P. Science (1977) [Pubmed]
  2. Dopaminergic defect of enteric nervous system in Parkinson's disease patients with chronic constipation. Singaram, C., Ashraf, W., Gaumnitz, E.A., Torbey, C., Sengupta, A., Pfeiffer, R., Quigley, E.M. Lancet (1995) [Pubmed]
  3. Vitamin A deficiency and genital viral burden in women infected with HIV-1. French, A.L., Cohen, M.H., Gange, S.J., Burger, H., Gao, W., Semba, R.D., Meyer, W.A., Robison, E., Anastos, K. Lancet (2002) [Pubmed]
  4. Myocardial blood flow distribution in patients with ischemic heart disease or dilated cardiomyopathy undergoing heart transplantation. Parodi, O., De Maria, R., Oltrona, L., Testa, R., Sambuceti, G., Roghi, A., Merli, M., Belingheri, L., Accinni, R., Spinelli, F. Circulation (1993) [Pubmed]
  5. Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury. McDonough, J.L., Arrell, D.K., Van Eyk, J.E. Circ. Res. (1999) [Pubmed]
  6. Comparative sequencing and association studies of aromatic L-amino acid decarboxylase in schizophrenia and bipolar disorder. Speight, G., Turic, D., Austin, J., Hoogendoorn, B., Cardno, A.G., Jones, L., Murphy, K.C., Sanders, R., McCarthy, G., Jones, I., McCandless, F., McGuffin, P., Craddock, N., Owen, M.J., Buckland, P., O'Donovan, M.C. Mol. Psychiatry (2000) [Pubmed]
  7. Determination of HP 749, a potential therapeutic agent for Alzheimer's disease, in plasma by high-performance liquid chromatography. Hsu, R.S., DiLeo, E.M., Chesson, S.M., Klein, J.T., Effland, R.C. J. Chromatogr. (1991) [Pubmed]
  8. CSF monoamine metabolites in patients and controls: support for a bimodal distribution in major affective disorders. Westenberg, H.G., Verhoeven, W.M. Acta psychiatrica Scandinavica. (1988) [Pubmed]
  9. Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness. Kamimori, G.H., Penetar, D.M., Headley, D.B., Thorne, D.R., Otterstetter, R., Belenky, G. Eur. J. Clin. Pharmacol. (2000) [Pubmed]
  10. Alkaline opening of imidazole ring of 7-methylguanosine. 2. Further studies on reaction mechanisms and products. Chetsanga, C.J., Makaroff, C. Chem. Biol. Interact. (1982) [Pubmed]
  11. Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors. Virgolini, I., Raderer, M., Kurtaran, A., Angelberger, P., Banyai, S., Yang, Q., Li, S., Banyai, M., Pidlich, J., Niederle, B., Scheithauer, W., Valent, P. N. Engl. J. Med. (1994) [Pubmed]
  12. An investigation of the cause of the eosinophilia-myalgia syndrome associated with tryptophan use. Belongia, E.A., Hedberg, C.W., Gleich, G.J., White, K.E., Mayeno, A.N., Loegering, D.A., Dunnette, S.L., Pirie, P.L., MacDonald, K.L., Osterholm, M.T. N. Engl. J. Med. (1990) [Pubmed]
  13. Peptide leukotriene release after antigen challenge in patients sensitive to ragweed. Creticos, P.S., Peters, S.P., Adkinson, N.F., Naclerio, R.M., Hayes, E.C., Norman, P.S., Lichtenstein, L.M. N. Engl. J. Med. (1984) [Pubmed]
  14. Familial hyperinsulinemia due to a structurally abnormal insulin. Definition of an emerging new clinical syndrome. Haneda, M., Polonsky, K.S., Bergenstal, R.M., Jaspan, J.B., Shoelson, S.E., Blix, P.M., Chan, S.J., Kwok, S.C., Wishner, W.B., Zeidler, A. N. Engl. J. Med. (1984) [Pubmed]
  15. A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon. Mallat, A., Pavoine, C., Dufour, M., Lotersztajn, S., Bataille, D., Pecker, F. Nature (1987) [Pubmed]
  16. Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Fellay, J., Marzolini, C., Meaden, E.R., Back, D.J., Buclin, T., Chave, J.P., Decosterd, L.A., Furrer, H., Opravil, M., Pantaleo, G., Retelska, D., Ruiz, L., Schinkel, A.H., Vernazza, P., Eap, C.B., Telenti, A. Lancet (2002) [Pubmed]
  17. Differentiation-associated expression of prostaglandin H and thromboxane A synthases in monocytoid leukemia cell lines. Sanduja, S.K., Mehta, K., Xu, X.M., Hsu, S.M., Sanduja, R., Wu, K.K. Blood (1991) [Pubmed]
  18. Prostaglandin synthesis by glomeruli isolated from rats with glycerol-induced acute renal failure. Sraer, J.D., Moulonguet-Doleris, L., Delarue, F., Sraer, J., Ardaillou, R. Circ. Res. (1981) [Pubmed]
  19. Two distinct tumor cell growth-inhibiting factors from a human rhabdomyosarcoma cell line. Fryling, C.M., Iwata, K.K., Johnson, P.A., Knott, W.B., Todaro, G.J. Cancer Res. (1985) [Pubmed]
  20. Pharmacokinetics of 4'-deoxy-4'-iodo-doxorubicin in plasma and tissues of tumor-bearing mice compared with doxorubicin. Formelli, F., Carsana, R., Pollini, C. Cancer Res. (1987) [Pubmed]
  21. Pharmacogenetic explanation for excessive beta-blockade following timolol eye drops. Potential for oral-ophthalmic drug interaction. Edeki, T.I., He, H., Wood, A.J. JAMA (1995) [Pubmed]
  22. Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues. Stevenson, F.T., Bursten, S.L., Locksley, R.M., Lovett, D.H. J. Exp. Med. (1992) [Pubmed]
  23. Fatty acid amide hydrolase controls mouse intestinal motility in vivo. Capasso, R., Matias, I., Lutz, B., Borrelli, F., Capasso, F., Marsicano, G., Mascolo, N., Petrosino, S., Monory, K., Valenti, M., Di Marzo, V., Izzo, A.A. Gastroenterology (2005) [Pubmed]
  24. Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome. de Morais, S.M., Uetrecht, J.P., Wells, P.G. Gastroenterology (1992) [Pubmed]
  25. Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA. Ozawa, N., Guengerich, F.P. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  26. IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells. Razin, E., Mencia-Huerta, J.M., Stevens, R.L., Lewis, R.A., Liu, F.T., Corey, E., Austen, K.F. J. Exp. Med. (1983) [Pubmed]
  27. Immunity in human schistosomiasis mansoni. Regulation of protective immune mechanisms by IgM blocking antibodies. Khalife, J., Capron, M., Capron, A., Grzych, J.M., Butterworth, A.E., Dunne, D.W., Ouma, J.H. J. Exp. Med. (1986) [Pubmed]
  28. Physiologic relevance of the membrane attack complex inhibitory protein CD59 in human seminal plasma: CD59 is present on extracellular organelles (prostasomes), binds cell membranes, and inhibits complement-mediated lysis. Rooney, I.A., Atkinson, J.P., Krul, E.S., Schonfeld, G., Polakoski, K., Saffitz, J.E., Morgan, B.P. J. Exp. Med. (1993) [Pubmed]
  29. Effects of butylated hydroxyanisole on the metabolism of benzo[a]pyrene by mouse liver microsomes. Lam, L.K., Wattenberg, L.W. J. Natl. Cancer Inst. (1977) [Pubmed]
  30. Retinol esterification by microsomes from the mucosa of human small intestine. Evidence for acyl-Coenzyme A retinol acyltransferase activity. Helgerud, P., Petersen, L.B., Norum, K.R. J. Clin. Invest. (1983) [Pubmed]
  31. Two methods of catecholamine depletion in kitten visual cortex yield different effects on plasticity. Bear, M.F., Paradiso, M.A., Schwartz, M., Nelson, S.B., Carnes, K.M., Daniels, J.D. Nature (1983) [Pubmed]
  32. The visual cycle operates via an isomerase acting on all-trans retinol in the pigment epithelium. Bridges, C.D., Alvarez, R.A. Science (1987) [Pubmed]
  33. A search for endogenous amino acids in martian meteorite ALH84001. Bada, J.L., Glavin, D.P., McDonald, G.D., Becker, L. Science (1998) [Pubmed]
  34. Chemical identification of a tumor-derived angiogenic factor. Kull, F.C., Brent, D.A., Parikh, I., Cuatrecasas, P. Science (1987) [Pubmed]
  35. Nonimmunological production of leukotrienes induced by platelet-activating factor. Voelkel, N.F., Worthen, S., Reeves, J.T., Henson, P.M., Murphy, R.C. Science (1982) [Pubmed]
  36. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. Van Damme, J., Proost, P., Lenaerts, J.P., Opdenakker, G. J. Exp. Med. (1992) [Pubmed]
  37. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Friso, S., Choi, S.W., Girelli, D., Mason, J.B., Dolnikowski, G.G., Bagley, P.J., Olivieri, O., Jacques, P.F., Rosenberg, I.H., Corrocher, R., Selhub, J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  38. Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor. Westermark, B., Johnsson, A., Paulsson, Y., Betsholtz, C., Heldin, C.H., Herlyn, M., Rodeck, U., Koprowski, H. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  39. Variegate porphyria in Western Europe: identification of PPOX gene mutations in 104 families, extent of allelic heterogeneity, and absence of correlation between phenotype and type of mutation. Whatley, S.D., Puy, H., Morgan, R.R., Robreau, A.M., Roberts, A.G., Nordmann, Y., Elder, G.H., Deybach, J.C. Am. J. Hum. Genet. (1999) [Pubmed]
  40. Carbonic anhydrase II deficiency: diagnosis and carrier detection using differential enzyme inhibition and inactivation. Sundaram, V., Rumbolo, P., Grubb, J., Strisciuglio, P., Sly, W.S. Am. J. Hum. Genet. (1986) [Pubmed]
  41. Circulating atrial natriuretic peptides in conscious rats: regulation of release by multiple factors. Eskay, R., Zukowska-Grojec, Z., Haass, M., Dave, J.R., Zamir, N. Science (1986) [Pubmed]
  42. Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin. Stone-Wolff, D.S., Yip, Y.K., Kelker, H.C., Le, J., Henriksen-Destefano, D., Rubin, B.Y., Rinderknecht, E., Aggarwal, B.B., Vilcek, J. J. Exp. Med. (1984) [Pubmed]
  43. Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation. Wright, S.C., Wei, Q.S., Zhong, J., Zheng, H., Kinder, D.H., Larrick, J.W. J. Exp. Med. (1994) [Pubmed]
  44. A new monoclonal antibody, mAb 4A12, identifies a role for the glycosaminoglycan (GAG) binding domain of RANTES in the antiviral effect against HIV-1 and intracellular Ca2+ signaling. Burns, J.M., Gallo, R.C., DeVico, A.L., Lewis, G.K. J. Exp. Med. (1998) [Pubmed]
  45. Production of chemotactic activity for polymorphonuclear leukocytes by cultured rat hepatocytes exposed to ethanol. Perez, H.D., Roll, F.J., Bissell, D.M., Shak, S., Goldstein, I.M. J. Clin. Invest. (1984) [Pubmed]
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