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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Multivariate Analysis

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Disease relevance of Multivariate Analysis


Psychiatry related information on Multivariate Analysis


High impact information on Multivariate Analysis

  • In a multivariate analysis, hydroxyephedrine retention was the only independent determinant of the exercise-induced increase in the ejection fraction [11].
  • In multivariate analysis, the presence or absence of a 17p deletion, the presence or absence of an 11q deletion, age, Binet stage, the serum lactate dehydrogenase level, and the white-cell count gave significant prognostic information [12].
  • Disparities in class II HLA alleles of the DRB1, DQA1, DQB1, DPA1, and DPB1 loci were not identified as significant risk factors for acute GVHD or death in the multivariate analysis [13].
  • When age and sex were controlled for in a multivariate analysis, low urinary iodine, high serum thyrotropin, and low serum thyroxine-binding globulin values were associated with an increased risk of Kashin-Beck disease, but a low serum selenium concentration was not [14].
  • Multivariate analysis incorporating prognostic factors from the international prognostic index demonstrated that p53 mutations had independent effects on the rates of complete remission and survival [15].

Chemical compound and disease context of Multivariate Analysis


Biological context of Multivariate Analysis

  • Multivariate analysis showed that the third heart sound was the strongest correlate of the response to digoxin (P less than 0.0001) [21].
  • Moreover, in both univariate and multivariate analyses, losses involving both chromosomes 1p and 19q were strongly associated with longer overall survival, whereas CDKN2A gene deletions and ring enhancement (i.e., contrast enhancement forming a rim around the tumor) on neuroimaging were associated with a significantly worse prognosis [22].
  • In multivariate analysis, there was a clear gene dosage effect of the H+ allele on HDL [23].
  • In chronic and accelerated phases of CML, CE was not associated with significant differences in major or complete cytogenetic response rates, but it was an independent poor prognostic factor for survival by multivariate analyses in both chronic (P =.005) and accelerated phase (P =.03) [24].
  • Donor MBL2 coding mutations and recipient HYA haplotype were independently associated with infection in multivariate analysis [25].

Anatomical context of Multivariate Analysis


Associations of Multivariate Analysis with chemical compounds


Gene context of Multivariate Analysis


Analytical, diagnostic and therapeutic context of Multivariate Analysis


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  14. Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status. Moreno-Reyes, R., Suetens, C., Mathieu, F., Begaux, F., Zhu, D., Rivera, M.T., Boelaert, M., Nève, J., Perlmutter, N., Vanderpas, J. N. Engl. J. Med. (1998) [Pubmed]
  15. Mutations of the p53 gene as a prognostic factor in aggressive B-cell lymphoma. Ichikawa, A., Kinoshita, T., Watanabe, T., Kato, H., Nagai, H., Tsushita, K., Saito, H., Hotta, T. N. Engl. J. Med. (1997) [Pubmed]
  16. Noninvasive prediction of fibrosis in C282Y homozygous hemochromatosis. Guyader, D., Jacquelinet, C., Moirand, R., Turlin, B., Mendler, M.H., Chaperon, J., David, V., Brissot, P., Adams, P., Deugnier, Y. Gastroenterology (1998) [Pubmed]
  17. Long-term instability of fasting plasma glucose, a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: the Verona Diabetes Study. Muggeo, M., Verlato, G., Bonora, E., Zoppini, G., Corbellini, M., de Marco, R. Circulation (1997) [Pubmed]
  18. Natural history of hypertrophic cardiomyopathy. A population-based study, 1976 through 1990. Cannan, C.R., Reeder, G.S., Bailey, K.R., Melton, L.J., Gersh, B.J. Circulation (1995) [Pubmed]
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  20. Multivariate analysis of prognostic factors in metastatic breast cancer. Hortobagyi, G.N., Smith, T.L., Legha, S.S., Swenerton, K.D., Gehan, E.A., Yap, H.Y., Buzdar, A.U., Blumenschein, G.R. J. Clin. Oncol. (1983) [Pubmed]
  21. Heart failure in outpatients: a randomized trial of digoxin versus placebo. Lee, D.C., Johnson, R.A., Bingham, J.B., Leahy, M., Dinsmore, R.E., Goroll, A.H., Newell, J.B., Strauss, H.W., Haber, E. N. Engl. J. Med. (1982) [Pubmed]
  22. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. Cairncross, J.G., Ueki, K., Zlatescu, M.C., Lisle, D.K., Finkelstein, D.M., Hammond, R.R., Silver, J.S., Stark, P.C., Macdonald, D.R., Ino, Y., Ramsay, D.A., Louis, D.N. J. Natl. Cancer Inst. (1998) [Pubmed]
  23. Polymorphisms in the lipoprotein lipase gene and their associations with plasma lipid concentrations in 40-year-old Danish men. Gerdes, C., Gerdes, L.U., Hansen, P.S., Faergeman, O. Circulation (1995) [Pubmed]
  24. Prognostic significance of cytogenetic clonal evolution in patients with chronic myelogenous leukemia on imatinib mesylate therapy. Cortes, J.E., Talpaz, M., Giles, F., O'Brien, S., Rios, M.B., Shan, J., Garcia-Manero, G., Faderl, S., Thomas, D.A., Wierda, W., Ferrajoli, A., Jeha, S., Kantarjian, H.M. Blood (2003) [Pubmed]
  25. Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation. Mullighan, C.G., Heatley, S., Doherty, K., Szabo, F., Grigg, A., Hughes, T.P., Schwarer, A.P., Szer, J., Tait, B.D., Bik To, L., Bardy, P.G. Blood (2002) [Pubmed]
  26. Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Mycoses Study Group and AIDS Clinical Trials Group. van der Horst, C.M., Saag, M.S., Cloud, G.A., Hamill, R.J., Graybill, J.R., Sobel, J.D., Johnson, P.C., Tuazon, C.U., Kerkering, T., Moskovitz, B.L., Powderly, W.G., Dismukes, W.E. N. Engl. J. Med. (1997) [Pubmed]
  27. p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation. Chang, H., Qi, C., Yi, Q.L., Reece, D., Stewart, A.K. Blood (2005) [Pubmed]
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