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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

HIV

 
 
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Disease relevance of HIV

 

Psychiatry related information on HIV

 

High impact information on HIV

  • The chemokine field has also received considerable attention since chemokine receptors were found to act as co-receptors for HIV infection (1) [11].
  • The selectivity of CD4+ cell destruction is due to the specific binding of gp120, the external envelope glycoprotein of HIV, to CD4, initiating viral entry [12].
  • HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into multivesicular bodies (MVB) [13].
  • We now show that HIV Gag p6 contains a second region involved in L domain function that binds AIP1, a homolog of the yeast class E Vps protein Bro1 [14].
  • Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection [15].
 

Chemical compound and disease context of HIV

 

Biological context of HIV

 

Anatomical context of HIV

  • During 10 to 68 months of observation, none of the four patients had evidence of infection with HIV type 1 or 2 or human T-cell lymphotropic virus type I or II on the basis of epidemiologic, serologic, or polymerase-chain-reaction studies or culture, nor was there any detectable reverse transcriptase activity [26].
  • Amphotropic retrovirus vectors were used to express the HIV envelope glycoprotein in a human CD4+ cell line [27].
  • We show here that expression of HIV envelope proteins allows syncytium formation between cells expressing human but not chimpanzee or macaque CD4 [28].
  • To produce concentrations of zidovudine (AZT) in plasma and cerebrospinal fluid that would provide constant inhibition of the replication of human immunodeficiency virus (HIV), we gave AZT by continuous intravenous infusion to 21 children ranging in age from 14 months to 12 years who had acquired HIV infection through transfusions or perinatally [29].
  • This sCD4 retains the structural and biological properties of CD4 on the cell surface, binds to the envelope glycoprotein (gp110) of HIV and inhibits the binding of virus to CD4+ lymphocytes, resulting in a striking inhibition of virus infectivity [30].
 

Gene context of HIV

  • Here, we show that the beta-chemokine receptor CKR-5 serves as a cofactor for M-tropic HIV viruses [31].
  • Entry of human immunodeficiency virus type 1 (HIV-1) into target cells requires both CD4 (ref. 1, 2) and one of a growing number of G-protein-coupled seven-transmembrane receptors [32].
  • These results indicate that the increased turnover of CD8+ T cells in HIV-infected subjects is mediated by the HIV envelope protein through the CXCR4 chemokine receptor [33].
  • HIV infection of MVECs stimulated surface expression of CD40 and allowed preferential induction of the vascular cell adhesion molecule VCAM-1 after CD40 triggering [34].
  • Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4 [35].
 

Analytical, diagnostic and therapeutic context of HIV

References

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