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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

DNA Damage

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Disease relevance of DNA Damage


Psychiatry related information on DNA Damage


High impact information on DNA Damage


Chemical compound and disease context of DNA Damage


Biological context of DNA Damage

  • Hence, p53 is not the only mediator of apoptosis provoked by DNA damage [20].
  • Phosphorylation of Dun1 increases in response to DNA damage in a Dun1-dependent manner, suggesting an increase in autophosphorylation activity [21].
  • Activation of the p53 transcription factor in response to a variety of cellular stresses, including DNA damage and oncogene activation, initiates a program of gene expression that blocks the proliferative expansion of damaged cells [22].
  • Surprisingly, both yKu and the chromatin-associated Rap1 and SIR proteins are released from telomeres in a RAD9-dependent response to DNA damage. yKu is recruited rapidly to double-strand cuts, while low levels of SIR proteins are detected near cleavage sites at later time points [23].
  • Here we report that RNA polymerase (pol) III transcription is repressed in response to DNA damage by downregulation of TFIIIB, the core component of the pol III transcriptional machinery [24].

Anatomical context of DNA Damage


Associations of DNA Damage with chemical compounds


Gene context of DNA Damage

  • EP300 acetylation of TP53 in response to DNA damage regulates its DNA-binding and transcription functions [35].
  • Although cells that lack BRCA1 have an abnormal response to DNA damage, the exact role of BRCA1 in this process has remained unclear [36].
  • These results provide novel insight into regulation of p21 protein and its role in the cellular response to DNA damage [37].
  • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage [36].
  • Deletion of SET1 increases the viability of mec3delta mutants after DNA damage (in a process that is mostly independent of Rad53p kinase, which has a central role in checkpoint control) but does not significantly affect cell-cycle progression [38].

Analytical, diagnostic and therapeutic context of DNA Damage


  1. A novel ubiquitin ligase is deficient in Fanconi anemia. Meetei, A.R., de Winter, J.P., Medhurst, A.L., Wallisch, M., Waisfisz, Q., van de Vrugt, H.J., Oostra, A.B., Yan, Z., Ling, C., Bishop, C.E., Hoatlin, M.E., Joenje, H., Wang, W. Nat. Genet. (2003) [Pubmed]
  2. Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy. Takashima, H., Boerkoel, C.F., John, J., Saifi, G.M., Salih, M.A., Armstrong, D., Mao, Y., Quiocho, F.A., Roa, B.B., Nakagawa, M., Stockton, D.W., Lupski, J.R. Nat. Genet. (2002) [Pubmed]
  3. A chromatin remodelling complex involved in transcription and DNA processing. Shen, X., Mizuguchi, G., Hamiche, A., Wu, C. Nature (2000) [Pubmed]
  4. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Seoane, J., Le, H.V., Massagué, J. Nature (2002) [Pubmed]
  5. A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. Lutzker, S.G., Levine, A.J. Nat. Med. (1996) [Pubmed]
  6. Alzheimer's disease cells exhibit defective repair of alkylating agent-induced DNA damage. Robison, S.H., Munzer, J.S., Tandan, R., Bradley, W.G. Ann. Neurol. (1987) [Pubmed]
  7. Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases? Chuang, D.M. Critical reviews in neurobiology. (2004) [Pubmed]
  8. Psychological mediation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-drinking workers. Irie, M., Asami, S., Nagata, S., Miyata, M., Kasai, H. Psychotherapy and psychosomatics. (2002) [Pubmed]
  9. Oxidative DNA damage in the aging mouse brain. Cardozo-Pelaez, F., Song, S., Parthasarathy, A., Hazzi, C., Naidu, K., Sanchez-Ramos, J. Mov. Disord. (1999) [Pubmed]
  10. Depressive state relates to female oxidative DNA damage via neutrophil activation. Irie, M., Asami, S., Ikeda, M., Kasai, H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  11. The genetic defect in ataxia-telangiectasia. Lavin, M.F., Shiloh, Y. Annu. Rev. Immunol. (1997) [Pubmed]
  12. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Meetei, A.R., Medhurst, A.L., Ling, C., Xue, Y., Singh, T.R., Bier, P., Steltenpool, J., Stone, S., Dokal, I., Mathew, C.G., Hoatlin, M., Joenje, H., de Winter, J.P., Wang, W. Nat. Genet. (2005) [Pubmed]
  13. hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Moumen, A., Masterson, P., O'Connor, M.J., Jackson, S.P. Cell (2005) [Pubmed]
  14. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Stucki, M., Clapperton, J.A., Mohammad, D., Yaffe, M.B., Smerdon, S.J., Jackson, S.P. Cell (2005) [Pubmed]
  15. DNA damage and oxygen radical toxicity. Imlay, J.A., Linn, S. Science (1988) [Pubmed]
  16. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Imlay, J.A., Chin, S.M., Linn, S. Science (1988) [Pubmed]
  17. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Wink, D.A., Kasprzak, K.S., Maragos, C.M., Elespuru, R.K., Misra, M., Dunams, T.M., Cebula, T.A., Koch, W.H., Andrews, A.W., Allen, J.S. Science (1991) [Pubmed]
  18. Estrogen and DNA damage: the silent source of breast cancer? Miller, K. J. Natl. Cancer Inst. (2003) [Pubmed]
  19. Stem cell factor stimulates neurogenesis in vitro and in vivo. Jin, K., Mao, X.O., Sun, Y., Xie, L., Greenberg, D.A. J. Clin. Invest. (2002) [Pubmed]
  20. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Strasser, A., Harris, A.W., Jacks, T., Cory, S. Cell (1994) [Pubmed]
  21. DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Zhou, Z., Elledge, S.J. Cell (1993) [Pubmed]
  22. p53: good cop/bad cop. Sharpless, N.E., DePinho, R.A. Cell (2002) [Pubmed]
  23. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Martin, S.G., Laroche, T., Suka, N., Grunstein, M., Gasser, S.M. Cell (1999) [Pubmed]
  24. TATA binding protein-associated CK2 transduces DNA damage signals to the RNA polymerase III transcriptional machinery. Ghavidel, A., Schultz, M.C. Cell (2001) [Pubmed]
  25. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Lincoln, A.J., Wickramasinghe, D., Stein, P., Schultz, R.M., Palko, M.E., De Miguel, M.P., Tessarollo, L., Donovan, P.J. Nat. Genet. (2002) [Pubmed]
  26. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Li, K., Li, Y., Shelton, J.M., Richardson, J.A., Spencer, E., Chen, Z.J., Wang, X., Williams, R.S. Cell (2000) [Pubmed]
  27. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Lee, J.S., Collins, K.M., Brown, A.L., Lee, C.H., Chung, J.H. Nature (2000) [Pubmed]
  28. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Gowen, L.C., Avrutskaya, A.V., Latour, A.M., Koller, B.H., Leadon, S.A. Science (1998) [Pubmed]
  29. The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Wang, X.W., Vermeulen, W., Coursen, J.D., Gibson, M., Lupold, S.E., Forrester, K., Xu, G., Elmore, L., Yeh, H., Hoeijmakers, J.H., Harris, C.C. Genes Dev. (1996) [Pubmed]
  30. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Shieh, S.Y., Ikeda, M., Taya, Y., Prives, C. Cell (1997) [Pubmed]
  31. Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Sanders, S.L., Portoso, M., Mata, J., Bähler, J., Allshire, R.C., Kouzarides, T. Cell (2004) [Pubmed]
  32. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Gozani, O., Karuman, P., Jones, D.R., Ivanov, D., Cha, J., Lugovskoy, A.A., Baird, C.L., Zhu, H., Field, S.J., Lessnick, S.L., Villasenor, J., Mehrotra, B., Chen, J., Rao, V.R., Brugge, J.S., Ferguson, C.G., Payrastre, B., Myszka, D.G., Cantley, L.C., Wagner, G., Divecha, N., Prestwich, G.D., Yuan, J. Cell (2003) [Pubmed]
  33. Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins. Ohndorf, U.M., Rould, M.A., He, Q., Pabo, C.O., Lippard, S.J. Nature (1999) [Pubmed]
  34. The octadecanoid signalling pathway in plants mediates a response to ultraviolet radiation. Conconi, A., Smerdon, M.J., Howe, G.A., Ryan, C.A. Nature (1996) [Pubmed]
  35. Mutations truncating the EP300 acetylase in human cancers. Gayther, S.A., Batley, S.J., Linger, L., Bannister, A., Thorpe, K., Chin, S.F., Daigo, Y., Russell, P., Wilson, A., Sowter, H.M., Delhanty, J.D., Ponder, B.A., Kouzarides, T., Caldas, C. Nat. Genet. (2000) [Pubmed]
  36. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Yarden, R.I., Pardo-Reoyo, S., Sgagias, M., Cowan, K.H., Brody, L.C. Nat. Genet. (2002) [Pubmed]
  37. UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair. Bendjennat, M., Boulaire, J., Jascur, T., Brickner, H., Barbier, V., Sarasin, A., Fotedar, A., Fotedar, R. Cell (2003) [Pubmed]
  38. Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions. Corda, Y., Schramke, V., Longhese, M.P., Smokvina, T., Paciotti, V., Brevet, V., Gilson, E., Géli, V. Nat. Genet. (1999) [Pubmed]
  39. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Sanchez, Y., Desany, B.A., Jones, W.J., Liu, Q., Wang, B., Elledge, S.J. Science (1996) [Pubmed]
  40. Action of DNA repair endonuclease ERCC1/XPF in living cells. Houtsmuller, A.B., Rademakers, S., Nigg, A.L., Hoogstraten, D., Hoeijmakers, J.H., Vermeulen, W. Science (1999) [Pubmed]
  41. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1. Kasibhatla, S., Brunner, T., Genestier, L., Echeverri, F., Mahboubi, A., Green, D.R. Mol. Cell (1998) [Pubmed]
  42. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage. Strano, S., Monti, O., Pediconi, N., Baccarini, A., Fontemaggi, G., Lapi, E., Mantovani, F., Damalas, A., Citro, G., Sacchi, A., Del Sal, G., Levrero, M., Blandino, G. Mol. Cell (2005) [Pubmed]
  43. p53 is associated with cellular microtubules and is transported to the nucleus by dynein. Giannakakou, P., Sackett, D.L., Ward, Y., Webster, K.R., Blagosklonny, M.V., Fojo, T. Nat. Cell Biol. (2000) [Pubmed]
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