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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

DNA Damage

 
 
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Disease relevance of DNA Damage

 

Psychiatry related information on DNA Damage

 

High impact information on DNA Damage

 

Chemical compound and disease context of DNA Damage

 

Biological context of DNA Damage

  • Hence, p53 is not the only mediator of apoptosis provoked by DNA damage [20].
  • Phosphorylation of Dun1 increases in response to DNA damage in a Dun1-dependent manner, suggesting an increase in autophosphorylation activity [21].
  • Activation of the p53 transcription factor in response to a variety of cellular stresses, including DNA damage and oncogene activation, initiates a program of gene expression that blocks the proliferative expansion of damaged cells [22].
  • Surprisingly, both yKu and the chromatin-associated Rap1 and SIR proteins are released from telomeres in a RAD9-dependent response to DNA damage. yKu is recruited rapidly to double-strand cuts, while low levels of SIR proteins are detected near cleavage sites at later time points [23].
  • Here we report that RNA polymerase (pol) III transcription is repressed in response to DNA damage by downregulation of TFIIIB, the core component of the pol III transcriptional machinery [24].
 

Anatomical context of DNA Damage

 

Associations of DNA Damage with chemical compounds

 

Gene context of DNA Damage

  • EP300 acetylation of TP53 in response to DNA damage regulates its DNA-binding and transcription functions [35].
  • Although cells that lack BRCA1 have an abnormal response to DNA damage, the exact role of BRCA1 in this process has remained unclear [36].
  • These results provide novel insight into regulation of p21 protein and its role in the cellular response to DNA damage [37].
  • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage [36].
  • Deletion of SET1 increases the viability of mec3delta mutants after DNA damage (in a process that is mostly independent of Rad53p kinase, which has a central role in checkpoint control) but does not significantly affect cell-cycle progression [38].
 

Analytical, diagnostic and therapeutic context of DNA Damage

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