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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

In Vitro

 
 
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Disease relevance of In Vitro

 

Psychiatry related information on In Vitro

 

High impact information on In Vitro

  • In this review we discuss some of the chemokines' biological effects in vivo and in vitro, described in the last few years, and the implications of these findings when considering chemokine receptors as therapeutic targets [11].
  • However, the molecular details as to how FcRn traffics within cells have yet to be fully understood, although in vitro systems have been developed for this purpose [12].
  • In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro [13].
  • Non-MHC Ir genes also contribute to the control of in vitro CTL responses to H-Y [14].
  • In vitro and biochemical experiments have implicated tyrosine kinases as key components of many of these signaling pathways [15].
 

Chemical compound and disease context of In Vitro

 

Biological context of In Vitro

  • In any event, the vastly different properties of the Eco SSB-binding modes must be considered in studies of DNA replication, recombination, and repair in vitro [21].
  • Substrates for telomerase are single-stranded oligonucleotides in vitro and chromosome ends in vivo [22].
  • Here we report the in vitro and in vivo consequences of converting these sites to alanine residues, which eliminates phosphorylation at these positions, or to aspartate residues, which mimics the negative charge state of the phosphorylated molecule [23].
  • For this function, p66Shc utilizes reducing equivalents of the mitochondrial electron transfer chain through the oxidation of cytochrome c. Redox-defective mutants of p66Shc are unable to induce mitochondrial ROS generation and swelling in vitro or to mediate mitochondrial apoptosis in vivo [24].
  • We demonstrate that So and Eya (1) regulate common steps in eye development including cell proliferation, patterning, and neuronal development; (2) synergize in inducing ectopic eyes; and (3) interact in yeast and in vitro through evolutionarily conserved domains [25].
 

Anatomical context of In Vitro

 

Associations of In Vitro with chemical compounds

  • The influence of thyroid hormone on estrogen actions has been demonstrated both in vivo and in vitro [31].
  • Oxysterols are variously metabolized to esters, bile acids, steroid hormones, cholesterol, or other sterols through pathways that may differ according to the type of cell and mode of experimentation (in vitro, in vivo, cell culture) [32].
  • The effects of caffeine and anesthetic agents on MHS and normal muscle are also discussed to better understand the basis for the in vitro clinical test for this disorder and mechanisms responsible for the initiation and maintenance of MH episodes in susceptible individuals [33].
  • They also block tubuloglomerular feedback responses in vivo and the vasoconstrictor response to elevations in tissue PO(2) both in vivo and in vitro [34].
  • Cells isolated from tumors formed at nonpermissive temperatures and recultured in vitro displayed temperature-dependent hexose transport and colony formation in agar similar to the orginal parent cell inoculum [35].
 

Gene context of In Vitro

 

Analytical, diagnostic and therapeutic context of In Vitro

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