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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Autoradiography

  • The blood-to-brain transfer of [14C]alpha-aminoisobutyric acid was investigated by quantitative autoradiography in normal rabbits and rabbits with acute liver failure induced by the selective hepatotoxin galactosamine [1].
  • The intracellular migration of G protein in vesicular stomatitis virus-infected cells was visualized by light and electron microscope radioautography after a 2-min pulse with [3H]mannose followed by nonradioactive chase for various intervals [2].
  • In vivo administration of 3H-labeled PK 11195 [1-(2-chlorophenyl-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide] or [3H]flunitrazepam with 5 mg of clonazepam per kg to rats with intracranial C6 gliomas resulted in high levels of tritiated-drug binding to the tumor as shown by quantitative autoradiography [3].
  • The genes were microinjected into the nuclei of TK-deficient (tk-) cells, and expression of the genes was determined by immunofluorescence staining for the simian virus 40 large tumor antigen and by [3H]thymidine incorporation followed by autoradiography for HSV TK [4].
  • Up to 80% of mouse Ltk- cells transfected with the herpes simplex virus thymidine kinase gene expressed thymidine kinase as measured by autoradiography [5].

Psychiatry related information on Autoradiography


High impact information on Autoradiography


Chemical compound and disease context of Autoradiography


Biological context of Autoradiography


Anatomical context of Autoradiography


Associations of Autoradiography with chemical compounds


Gene context of Autoradiography

  • Autoradiography showed that the vast majority of the synoviocytes within the cultures possessed IL-1 receptors [36].
  • METHODS: Visualization and quantification of 125I-Bolton-Hunter sulfated CCK octapeptide (125I-BH-CCK-8) binding to tissue sections of the human pancreas and gallbladder were performed by storage phosphor autoradiography [37].
  • The analog photocrosslinks specifically to the recombinant hPTH/PTHrP receptor stably transfected into human embryonic kidney cells (HEK-293/C-21 cells, approximately 400,000 receptors per cell), generating a diffuse approximately 87-kDa band on SDS/PAGE autoradiography [38].
  • Distribution of AT1 and AT2 receptors was determined by competition with losartan and PD123177, respectively, and the density of the receptors was quantified by emulsion autoradiography [39].
  • Quantitative autoradiography with subtype-selective radioligands revealed similar small proportions of ETB receptors in the diseased and normal arterial media [40].

Analytical, diagnostic and therapeutic context of Autoradiography


  1. Increased blood-brain transfer in a rabbit model of acute liver failure. Horowitz, M.E., Schafer, D.F., Molnar, P., Jones, E.A., Blasberg, R.G., Patlak, C.S., Waggoner, J., Fenstermacher, J.D. Gastroenterology (1983) [Pubmed]
  2. Intracellular transport of the transmembrane glycoprotein G of vesicular stomatitis virus through the Golgi apparatus as visualized by electron microscope radioautography. Bergeron, J.J., Kotwal, G.J., Levine, G., Bilan, P., Rachubinski, R., Hamilton, M., Shore, G.C., Ghosh, H.P. J. Cell Biol. (1982) [Pubmed]
  3. Imaging of a glioma using peripheral benzodiazepine receptor ligands. Starosta-Rubinstein, S., Ciliax, B.J., Penney, J.B., McKeever, P., Young, A.B. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  4. Effect of methylation on expression of microinjected genes. Waechter, D.E., Baserga, R. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  5. Short-term, high-efficiency expression of transfected DNA. Sussman, D.J., Milman, G. Mol. Cell. Biol. (1984) [Pubmed]
  6. Carbachol stimulates [35S]guanylyl 5'-(gamma-thio)-triphosphate binding in rapid eye movement sleep-related brainstem nuclei of rat. Capece, M.L., Baghdoyan, H.A., Lydic, R. J. Neurosci. (1998) [Pubmed]
  7. 125I-galanin binding sites in Alzheimer's disease: increases in hippocampal subfields and a decrease in the caudate nucleus. Rodríguez-Puertas, R., Nilsson, S., Pascual, J., Pazos, A., Hökfelt, T. J. Neurochem. (1997) [Pubmed]
  8. Mouse brain c-fos mRNA distribution following a single electroconvulsive shock. Daval, J.L., Nakajima, T., Gleiter, C.H., Post, R.M., Marangos, P.J. J. Neurochem. (1989) [Pubmed]
  9. The problem of antipsychotic treatment for functional imaging in Huntington's disease: receptor binding, gene expression and locomotor activity after sub-chronic administration and wash-out of haloperidol in the rat. Besret, L., Page, K.J., Dunnett, S.B. Brain Res. (2000) [Pubmed]
  10. Robust amplification and ethidium-visible detection of the fragile X syndrome CGG repeat using Pfu polymerase. Chong, S.S., Eichler, E.E., Nelson, D.L., Hughes, M.R. Am. J. Med. Genet. (1994) [Pubmed]
  11. Vitamin D: recent advances. DeLuca, H.F., Schnoes, H.K. Annu. Rev. Biochem. (1983) [Pubmed]
  12. Inhibition of thymidine kinase gene expression by anti-sense RNA: a molecular approach to genetic analysis. Izant, J.G., Weintraub, H. Cell (1984) [Pubmed]
  13. Loss of reiterated DNA sequences during serial passage of human diploid fibroblasts. Shmookler Reis, R.J., Goldstein, S. Cell (1980) [Pubmed]
  14. Organization of human delta--and beta-globin genes in cellular DNA and the presence of intragenic inserts. Mears, J.G., Ramirez, F., Leibowitz, D., Bank, A. Cell (1978) [Pubmed]
  15. The temporal structure of S phase. Klevecz, R.R., Keniston, B.A. Cell (1975) [Pubmed]
  16. Time course of increased collateral arterial and venous endothelial cell turnover after renal artery stenosis in the rat. Ilich, N., Hollenberg, N.K., Williams, D.H., Abrams, H.L. Circ. Res. (1979) [Pubmed]
  17. Regional cerebral glucose utilization reveals widespread abnormalities in the motor system of the rat mutant dystonic. Brown, L.L., Lorden, J.F. J. Neurosci. (1989) [Pubmed]
  18. Regional blood-to-tissue transport in ethylnitrosourea-induced brain tumors. Blasberg, R.G., Kobayashi, T., Horowitz, M., Rice, J.M., Groothuis, D., Molnar, P., Fenstermacher, J.D. Ann. Neurol. (1983) [Pubmed]
  19. Autoradiographic localization of glycoprotein in human breast cancer cells maintained in organ culture after incubation with (3H)fucose or (3H)glucosamine. Dermer, G.B., Sherwin, R.P. Cancer Res. (1975) [Pubmed]
  20. Regional blood flow in ethylnitrosourea-induced brain tumors. Blasberg, R.G., Kobayashi, T., Horowitz, M., Rice, J.M., Groothuis, D., Molnar, P., Fenstermacher, J.D. Ann. Neurol. (1983) [Pubmed]
  21. Electron microscopic autoradiographic localization of opioid receptors in rat neostriatum. Hamel, E., Beaudet, A. Nature (1984) [Pubmed]
  22. Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Bravo, R., Frank, R., Blundell, P.A., Macdonald-Bravo, H. Nature (1987) [Pubmed]
  23. Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS. Mantyh, P.W., Pinnock, R.D., Downes, C.P., Goedert, M., Hunt, S.P. Nature (1984) [Pubmed]
  24. Decreased rate of DNA-chain growth in human basal cell carcinoma. Heenen, M., Galand, P. Nature (1980) [Pubmed]
  25. Vascular smooth muscle cell kinetics: a new assay for studying patterns of cellular proliferation in vivo. Goldberg, I.D., Stemerman, M.B., Schnipper, L.E., Ransil, B.J., Crooks, G.W., Fuhro, R.L. Science (1979) [Pubmed]
  26. Development of orientation columns in cat striate cortex revealed by 2-deoxyglucose autoradiography. Thompson, I.D., Kossut, M., Blakemore, C. Nature (1983) [Pubmed]
  27. Corticotropin-releasing factor receptors in rat forebrain: autoradiographic identification. De Souza, E.B., Perrin, M.H., Insel, T.R., Rivier, J., Vale, W.W., Kuhar, M.J. Science (1984) [Pubmed]
  28. Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin A. Renston, R.H., Jones, A.L., Christiansen, W.D., Hradek, G.T., Underdown, B.J. Science (1980) [Pubmed]
  29. Chitin synthetase distribution on the yeast plasma membrane. Duran, A., Cabib, E., Bowers, B. Science (1979) [Pubmed]
  30. Pulsing electromagnetic fields induce cellular transcription. Goodman, R., Bassett, C.A., Henderson, A.S. Science (1983) [Pubmed]
  31. Localization of D-2 dopamine receptors to intrinsic striatal neurones by quantitative autoradiography. Trugman, J.M., Geary, W.A., Wooten, G.F. Nature (1986) [Pubmed]
  32. Acceptors for botulinum neurotoxin reside on motor nerve terminals and mediate its internalization. Dolly, J.O., Black, J., Williams, R.S., Melling, J. Nature (1984) [Pubmed]
  33. Androgen receptors in the brain: what are we measuring? Sheridan, P.J. Endocr. Rev. (1983) [Pubmed]
  34. DNA synthesis and mitosis in adult amphibian cardiac muscle cells in vitro. Nag, A.C., Healy, C.J., Cheng, M. Science (1979) [Pubmed]
  35. Brain dopamine and serotonin receptor sites revealed by digital subtraction autoradiography. Altar, C.A., O'Neil, S., Walter, R.J., Marshall, J.F. Science (1985) [Pubmed]
  36. Identification of a high-affinity receptor for interleukin 1 alpha and interleukin 1 beta on cultured human rheumatoid synovial cells. Chin, J., Rupp, E., Cameron, P.M., MacNaul, K.L., Lotke, P.A., Tocci, M.J., Schmidt, J.A., Bayne, E.K. J. Clin. Invest. (1988) [Pubmed]
  37. Cholecystokinin receptors in human pancreas and gallbladder muscle: a comparative study. Tang, C., Biemond, I., Lamers, C.B. Gastroenterology (1996) [Pubmed]
  38. Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking. Zhou, A.T., Bessalle, R., Bisello, A., Nakamoto, C., Rosenblatt, M., Suva, L.J., Chorev, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  39. Characterization of angiotensin II receptor subtypes in rat heart. Sechi, L.A., Griffin, C.A., Grady, E.F., Kalinyak, J.E., Schambelan, M. Circ. Res. (1992) [Pubmed]
  40. Endothelin peptide and receptors in human atherosclerotic coronary artery and aorta. Bacon, C.R., Cary, N.R., Davenport, A.P. Circ. Res. (1996) [Pubmed]
  41. Isolation and partial characterization of a specific alpha-fetoprotein receptor on human monocytes. Suzuki, Y., Zeng, C.Q., Alpert, E. J. Clin. Invest. (1992) [Pubmed]
  42. gamma-Aminobutyric acid localization and function as modulator of cholinergic neurotransmission in rat antral mucosal/submucosal fragments. Harty, R.F., Boharski, M.G., Bochna, G.S., Carr, T.A., Eagan, P.E., Rings, M., Lassiter, D.C., Pour, M.P., Schafer, D.F., Markin, R.S. Gastroenterology (1991) [Pubmed]
  43. 21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. Winqvist, O., Karlsson, F.A., Kämpe, O. Lancet (1992) [Pubmed]
  44. Autoradiographic study of the regional distribution of gastric blood flow in portal hypertensive rats. Geraghty, J.G., Angerson, W.J., Carter, D.C. Gastroenterology (1989) [Pubmed]
  45. Purified thick filaments from the nematode Caenorhabditis elegans: evidence for multiple proteins associated with core structures. Epstein, H.F., Berliner, G.C., Casey, D.L., Ortiz, I. J. Cell Biol. (1988) [Pubmed]
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