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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Mice, Nude

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Disease relevance of Mice, Nude


Psychiatry related information on Mice, Nude

  • In addition, either the individual or pooled RB+ clones did form malignant tumors in nude mice but usually with a longer latency period and lower frequency [6].
  • Our purpose was to determine the therapeutic efficacy of a selective-spectrum MMPI, ONO-4817 (inhibits MMP-2 and MMP-9 but not MMP-1), against established lung micrometastasis in combination with a cytotoxic anticancer drug, DOC, in a nude mouse model [7].

High impact information on Mice, Nude

  • Inactivation of p38 MAPK (the product of Mapk14) in vivo by gene targeting or by PPM1D overexpression expedited tumor formation after injection of mouse embryo fibroblasts (MEFs) expressing E1A+Ras into nude mice [8].
  • Restoration of TSLC1 expression to normal or higher levels suppresses tumor formation by A549 cells in nude mice [9].
  • The defect was not corrected by grafting of Klf4-/- skin onto nude mice [10].
  • Furthermore, normal RLE cells are rapidly transformed when Bog is continuously overexpressed and form hepatoblastoma-like tumours when transplanted into nude mice [11].
  • Recent work has identified a mouse gene (tsg101) whose inactivation in fibroblasts results in cellular transformation and the ability to produce metastatic tumors in nude mice [12].

Chemical compound and disease context of Mice, Nude


Biological context of Mice, Nude


Anatomical context of Mice, Nude


Associations of Mice, Nude with chemical compounds


Gene context of Mice, Nude

  • Simultaneous adenoviral transfer of p16 and p53 genes leads to inhibition of tumor growth in nude mice [33].
  • One representative human TNF mutant retains its antitumour activity in nude mice carrying tumours derived from human cancers [34].
  • Moreover, mouse asialo-IFN-beta profoundly reduced viremia in vivo in HBV-transfected athymic nude mice, in contrast to conventional IFN-beta, which had no substantial effect [35].
  • Cells expressing mox1 have a transformed appearance, show anchorage-independent growth and produce tumours in athymic mice [36].
  • Transcription of the alpha chain gene was not induced in the NK cell-abundant athymic mice after IL-2 treatment [37].

Analytical, diagnostic and therapeutic context of Mice, Nude


  1. The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Oh, J., Takahashi, R., Kondo, S., Mizoguchi, A., Adachi, E., Sasahara, R.M., Nishimura, S., Imamura, Y., Kitayama, H., Alexander, D.B., Ide, C., Horan, T.P., Arakawa, T., Yoshida, H., Nishikawa, S., Itoh, Y., Seiki, M., Itohara, S., Takahashi, C., Noda, M. Cell (2001) [Pubmed]
  2. Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y., Inoue, S. Nature (2002) [Pubmed]
  3. A polymeric form of fibronectin has antimetastatic effects against multiple tumor types. Pasqualini, R., Bourdoulous, S., Koivunen, E., Woods, V.L., Ruoslahti, E. Nat. Med. (1996) [Pubmed]
  4. Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Murray, G.I., Duncan, M.E., O'Neil, P., Melvin, W.T., Fothergill, J.E. Nat. Med. (1996) [Pubmed]
  5. A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo. DeFeo-Jones, D., Garsky, V.M., Wong, B.K., Feng, D.M., Bolyar, T., Haskell, K., Kiefer, D.M., Leander, K., McAvoy, E., Lumma, P., Wai, J., Senderak, E.T., Motzel, S.L., Keenan, K., Van Zwieten, M., Lin, J.H., Freidinger, R., Huff, J., Oliff, A., Jones, R.E. Nat. Med. (2000) [Pubmed]
  6. Further characterization of retinoblastoma gene-mediated cell growth and tumor suppression in human cancer cells. Zhou, Y., Li, J., Xu, K., Hu, S.X., Benedict, W.F., Xu, H.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. A third-generation matrix metalloproteinase (MMP) inhibitor (ONO-4817) combined with docetaxel suppresses progression of lung micrometastasis of MMP-expressing tumor cells in nude mice. Yamamoto, A., Yano, S., Shiraga, M., Ogawa, H., Goto, H., Miki, T., Zhang, H., Sone, S. Int. J. Cancer (2003) [Pubmed]
  8. Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity. Bulavin, D.V., Demidov, O.N., Saito, S., Kauraniemi, P., Phillips, C., Amundson, S.A., Ambrosino, C., Sauter, G., Nebreda, A.R., Anderson, C.W., Kallioniemi, A., Fornace, A.J., Appella, E. Nat. Genet. (2002) [Pubmed]
  9. TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Kuramochi, M., Fukuhara, H., Nobukuni, T., Kanbe, T., Maruyama, T., Ghosh, H.P., Pletcher, M., Isomura, M., Onizuka, M., Kitamura, T., Sekiya, T., Reeves, R.H., Murakami, Y. Nat. Genet. (2001) [Pubmed]
  10. Klf4 is a transcription factor required for establishing the barrier function of the skin. Segre, J.A., Bauer, C., Fuchs, E. Nat. Genet. (1999) [Pubmed]
  11. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Woitach, J.T., Zhang, M., Niu, C.H., Thorgeirsson, S.S. Nat. Genet. (1998) [Pubmed]
  12. The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer. Li, L., Li, X., Francke, U., Cohen, S.N. Cell (1997) [Pubmed]
  13. Human endometrial adenocarcinoma transplanted into nude mice: growth regulation by estradiol. Satyaswaroop, P.G., Zaino, R.J., Mortel, R. Science (1983) [Pubmed]
  14. Subclass-restricted IgG polyclonal antibody production in mice injected with lipid A-rich lipopolysaccharides. Izui, S., Eisenberg, R.A., Dixon, F.J. J. Exp. Med. (1981) [Pubmed]
  15. DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology. Labrie, F., Luu-The, V., Labrie, C., Simard, J. Frontiers in neuroendocrinology. (2001) [Pubmed]
  16. Functional analysis of influenza-specific helper T cell clones in vivo. T cells specific for internal viral proteins provide cognate help for B cell responses to hemagglutinin. Scherle, P.A., Gerhard, W. J. Exp. Med. (1986) [Pubmed]
  17. Eradication of established human melanoma tumors in nude mice by antibody-directed effector cells. Schulz, G., Staffileno, L.K., Reisfeld, R.A., Dennert, G. J. Exp. Med. (1985) [Pubmed]
  18. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, I., Grignani, F., Pawson, T., Pelicci, P.G. Cell (1992) [Pubmed]
  19. Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals. Keath, E.J., Caimi, P.G., Cole, M.D. Cell (1984) [Pubmed]
  20. The v-fms oncogene induces factor independence and tumorigenicity in CSF-1 dependent macrophage cell line. Wheeler, E.F., Rettenmier, C.W., Look, A.T., Sherr, C.J. Nature (1986) [Pubmed]
  21. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Zou, Z., Anisowicz, A., Hendrix, M.J., Thor, A., Neveu, M., Sheng, S., Rafidi, K., Seftor, E., Sager, R. Science (1994) [Pubmed]
  22. Failure of T cell receptor V beta negative selection in an athymic environment. Hodes, R.J., Sharrow, S.O., Solomon, A. Science (1989) [Pubmed]
  23. Gain of function mutations in p53. Dittmer, D., Pati, S., Zambetti, G., Chu, S., Teresky, A.K., Moore, M., Finlay, C., Levine, A.J. Nat. Genet. (1993) [Pubmed]
  24. Differential genetic susceptibility of cultured human skin fibroblasts to transformation by Kirsten murine sarcoma virus. Pfeffer, L.M., Kopelovich, L. Cell (1977) [Pubmed]
  25. Comparative growth of bovine lymphosarcoma cells and lymphoid cells infected with Theileria parva in athymic (nude) mice. Irvin, A.D., Brown, C.G., Kanhai, G.K., Stagg, D.A. Nature (1975) [Pubmed]
  26. Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia. Bos, J.L., Toksoz, D., Marshall, C.J., Verlaan-de Vries, M., Veeneman, G.H., van der Eb, A.J., van Boom, J.H., Janssen, J.W., Steenvoorden, A.C. Nature (1985) [Pubmed]
  27. Vascular endothelial growth factor: basic science and clinical progress. Ferrara, N. Endocr. Rev. (2004) [Pubmed]
  28. Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth. Dickson, R.B., McManaway, M.E., Lippman, M.E. Science (1986) [Pubmed]
  29. Sensitivity to carcinogenesis in nude mice: skin tumors caused by transplacental exposure to ethylnitrosourea. Anderson, L.M., Last-Barney, K., Budinger, J.M. Science (1982) [Pubmed]
  30. Murine model for human secondary amyloidosis: genetic variability of the acute-phase serum protein SAA response to endotoxins and casein. McAdam, K.P., Sipe, J.D. J. Exp. Med. (1976) [Pubmed]
  31. Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivo. Bukowski, J.F., Warner, J.F., Dennert, G., Welsh, R.M. J. Exp. Med. (1985) [Pubmed]
  32. Thymus-like activities of sulphur derivatives on T-cell differentiation. Renoux, G., Renoux, M. J. Exp. Med. (1977) [Pubmed]
  33. Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death. Sandig, V., Brand, K., Herwig, S., Lukas, J., Bartek, J., Strauss, M. Nat. Med. (1997) [Pubmed]
  34. Human TNF mutants with selective activity on the p55 receptor. Van Ostade, X., Vandenabeele, P., Everaerdt, B., Loetscher, H., Gentz, R., Brockhaus, M., Lesslauer, W., Tavernier, J., Brouckaert, P., Fiers, W. Nature (1993) [Pubmed]
  35. Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon. Eto, T., Takahashi, H. Nat. Med. (1999) [Pubmed]
  36. Cell transformation by the superoxide-generating oxidase Mox1. Suh, Y.A., Arnold, R.S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A.B., Griendling, K.K., Lambeth, J.D. Nature (1999) [Pubmed]
  37. Interleukin 2-induced proliferation of murine natural killer cells in vivo. Biron, C.A., Young, H.A., Kasaian, M.T. J. Exp. Med. (1990) [Pubmed]
  38. Eradication of adenovirus E1-induced tumors by E1A-specific cytotoxic T lymphocytes. Kast, W.M., Offringa, R., Peters, P.J., Voordouw, A.C., Meloen, R.H., van der Eb, A.J., Melief, C.J. Cell (1989) [Pubmed]
  39. In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Chan, B.M., Matsuura, N., Takada, Y., Zetter, B.R., Hemler, M.E. Science (1991) [Pubmed]
  40. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. Ghiringhelli, F., Ménard, C., Terme, M., Flament, C., Taieb, J., Chaput, N., Puig, P.E., Novault, S., Escudier, B., Vivier, E., Lecesne, A., Robert, C., Blay, J.Y., Bernard, J., Caillat-Zucman, S., Freitas, A., Tursz, T., Wagner-Ballon, O., Capron, C., Vainchencker, W., Martin, F., Zitvogel, L. J. Exp. Med. (2005) [Pubmed]
  41. Enhanced success rate of transplantation with human tumors in cyclophosphamide-treated nude mice. Braakhuis, B.J., Nauta, M.M., Romijn, J.C., Rutgers, D.H., Smink, T. J. Natl. Cancer Inst. (1986) [Pubmed]
  42. Effects of cimetidine on tumor growth and immune function in nude mice bearing human ovarian carcinoma. Kikuchi, Y., Oomori, K., Kizawa, I., Kato, K. J. Natl. Cancer Inst. (1985) [Pubmed]
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