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MeSH Review

Amyotrophic Lateral Sclerosis

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Disease relevance of Amyotrophic Lateral Sclerosis


Psychiatry related information on Amyotrophic Lateral Sclerosis


High impact information on Amyotrophic Lateral Sclerosis


Chemical compound and disease context of Amyotrophic Lateral Sclerosis


Biological context of Amyotrophic Lateral Sclerosis


Anatomical context of Amyotrophic Lateral Sclerosis


Gene context of Amyotrophic Lateral Sclerosis


Analytical, diagnostic and therapeutic context of Amyotrophic Lateral Sclerosis


  1. ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis. Greenway, M.J., Andersen, P.M., Russ, C., Ennis, S., Cashman, S., Donaghy, C., Patterson, V., Swingler, R., Kieran, D., Prehn, J., Morrison, K.E., Green, A., Acharya, K.R., Brown, R.H., Hardiman, O. Nat. Genet. (2006) [Pubmed]
  2. Protein aggregation and neurodegenerative disease. Ross, C.A., Poirier, M.A. Nat. Med. (2004) [Pubmed]
  3. The genetic epidemiology of neurodegenerative disease. Bertram, L., Tanzi, R.E. J. Clin. Invest. (2005) [Pubmed]
  4. A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor. Pollitt, S.K., Pallos, J., Shao, J., Desai, U.A., Ma, A.A., Thompson, L.M., Marsh, J.L., Diamond, M.I. Neuron (2003) [Pubmed]
  5. Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration? Trotti, D., Danbolt, N.C., Volterra, A. Trends Pharmacol. Sci. (1998) [Pubmed]
  6. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. Minghetti, L. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  7. Peripheral markers of glutamatergic dysfunction in neurological diseases: focus on ex vivo tools. Tremolizzo, L., Beretta, S., Ferrarese, C. Critical reviews in neurobiology. (2004) [Pubmed]
  8. Increase of glial fibrillary acidic protein fragments in the spinal cord of motor neuron degeneration mutant mouse. Fujita, K., Yamauchi, M., Matsui, T., Titani, K., Takahashi, H., Kato, T., Isomura, G., Ando, M., Nagata, Y. Brain Res. (1998) [Pubmed]
  9. Amyotrophic lateral sclerosis presenting with sleep hypopnea syndrome. Carre, P.C., Didier, A.P., Tiberge, Y.M., Arbus, L.J., Leophonte, P.J. Chest (1988) [Pubmed]
  10. Measurement of health-related quality of life in patients with amyotrophic lateral sclerosis in clinical trials of new therapies. Damiano, A.M., Patrick, D.L., Guzman, G.I., Gawel, M.J., Gelinas, D.F., Natter, H.M., Ingalls, K.K. Medical care. (1999) [Pubmed]
  11. Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. Selverstone Valentine, J., Doucette, P.A., Zittin Potter, S. Annu. Rev. Biochem. (2005) [Pubmed]
  12. Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse. Schmitt-John, T., Drepper, C., Mussmann, A., Hahn, P., Kuhlmann, M., Thiel, C., Hafner, M., Lengeling, A., Heimann, P., Jones, J.M., Meisler, M.H., Jockusch, H. Nat. Genet. (2005) [Pubmed]
  13. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Lambrechts, D., Storkebaum, E., Morimoto, M., Del-Favero, J., Desmet, F., Marklund, S.L., Wyns, S., Thijs, V., Andersson, J., van Marion, I., Al-Chalabi, A., Bornes, S., Musson, R., Hansen, V., Beckman, L., Adolfsson, R., Pall, H.S., Prats, H., Vermeire, S., Rutgeerts, P., Katayama, S., Awata, T., Leigh, N., Lang-Lazdunski, L., Dewerchin, M., Shaw, C., Moons, L., Vlietinck, R., Morrison, K.E., Robberecht, W., Van Broeckhoven, C., Collen, D., Andersen, P.M., Carmeliet, P. Nat. Genet. (2003) [Pubmed]
  14. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. Rothstein, J.D., Martin, L.J., Kuncl, R.W. N. Engl. J. Med. (1992) [Pubmed]
  15. Riluzole in amyotrophic lateral sclerosis. McKee, P., Fuller, G.N., Stevens, D.L. N. Engl. J. Med. (1994) [Pubmed]
  16. The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Yang, Y., Hentati, A., Deng, H.X., Dabbagh, O., Sasaki, T., Hirano, M., Hung, W.Y., Ouahchi, K., Yan, J., Azim, A.C., Cole, N., Gascon, G., Yagmour, A., Ben-Hamida, M., Pericak-Vance, M., Hentati, F., Siddique, T. Nat. Genet. (2001) [Pubmed]
  17. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Klivenyi, P., Ferrante, R.J., Matthews, R.T., Bogdanov, M.B., Klein, A.M., Andreassen, O.A., Mueller, G., Wermer, M., Kaddurah-Daouk, R., Beal, M.F. Nat. Med. (1999) [Pubmed]
  18. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Zhu, S., Stavrovskaya, I.G., Drozda, M., Kim, B.Y., Ona, V., Li, M., Sarang, S., Liu, A.S., Hartley, D.M., Wu, d.u. .C., Gullans, S., Ferrante, R.J., Przedborski, S., Kristal, B.S., Friedlander, R.M. Nature (2002) [Pubmed]
  19. Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Aebischer, P., Schluep, M., Déglon, N., Joseph, J.M., Hirt, L., Heyd, B., Goddard, M., Hammang, J.P., Zurn, A.D., Kato, A.C., Regli, F., Baetge, E.E. Nat. Med. (1996) [Pubmed]
  20. Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene. Eymard-Pierre, E., Lesca, G., Dollet, S., Santorelli, F.M., di Capua, M., Bertini, E., Boespflug-Tanguy, O. Am. J. Hum. Genet. (2002) [Pubmed]
  21. The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. Eubanks, J.H., Puranam, R.S., Kleckner, N.W., Bettler, B., Heinemann, S.F., McNamara, J.O. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  22. Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS. Drachman, D.B., Frank, K., Dykes-Hoberg, M., Teismann, P., Almer, G., Przedborski, S., Rothstein, J.D. Ann. Neurol. (2002) [Pubmed]
  23. Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex. Bristol, L.A., Rothstein, J.D. Ann. Neurol. (1996) [Pubmed]
  24. Regional changes of ciliary neurotrophic factor and nerve growth factor levels in post mortem spinal cord and cerebral cortex from patients with motor disease. Anand, P., Parrett, A., Martin, J., Zeman, S., Foley, P., Swash, M., Leigh, P.N., Cedarbaum, J.M., Lindsay, R.M., Williams-Chestnut, R.E. Nat. Med. (1995) [Pubmed]
  25. Pulmonary effects of thyrotropin-releasing hormone in amyotrophic lateral sclerosis. Braun, S.R., Sufit, R.L., Brooks, B.R. Lancet (1984) [Pubmed]
  26. Amyotrophic lateral sclerosis: amino acid levels in plasma and cerebrospinal fluid. Perry, T.L., Krieger, C., Hansen, S., Eisen, A. Ann. Neurol. (1990) [Pubmed]
  27. Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: a hypothesis. Plaitakis, A. Ann. Neurol. (1990) [Pubmed]
  28. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Nguyen, M.D., Larivière, R.C., Julien, J.P. Neuron (2001) [Pubmed]
  29. The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis. Khare, S.D., Caplow, M., Dokholyan, N.V. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  30. Early onset of severe familial amyotrophic lateral sclerosis with a SOD-1 mutation: potential impact of CNTF as a candidate modifier gene. Giess, R., Holtmann, B., Braga, M., Grimm, T., Müller-Myhsok, B., Toyka, K.V., Sendtner, M. Am. J. Hum. Genet. (2002) [Pubmed]
  31. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Rabizadeh, S., Gralla, E.B., Borchelt, D.R., Gwinn, R., Valentine, J.S., Sisodia, S., Wong, P., Lee, M., Hahn, H., Bredesen, D.E. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  32. Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL. Raoul, C., Buhler, E., Sadeghi, C., Jacquier, A., Aebischer, P., Pettmann, B., Henderson, C.E., Haase, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  33. Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors. Couratier, P., Hugon, J., Sindou, P., Vallat, J.M., Dumas, M. Lancet (1993) [Pubmed]
  34. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Matthews, R.T., Yang, L., Browne, S., Baik, M., Beal, M.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  35. Effects of riluzole on cortical excitability in patients with amyotrophic lateral sclerosis. Stefan, K., Kunesch, E., Benecke, R., Classen, J. Ann. Neurol. (2001) [Pubmed]
  36. Immunoassays fail to detect antibodies against neuronal calcium channels in amyotrophic lateral sclerosis serum. Arsac, C., Raymond, C., Martin-Moutot, N., Dargent, B., Couraud, F., Pouget, J., Seagar, M. Ann. Neurol. (1996) [Pubmed]
  37. Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF. Aebischer, P., Pochon, N.A., Heyd, B., Deglon, N., Joseph, J.M., Zurn, A.D., Baetge, E.E., Hammang, J.P., Goddard, M., Lysaght, M., Kaplan, F., Kato, A.C., Schluep, M., Hirt, L., Regli, F., Porchet, F., De Tribolet, N. Hum. Gene Ther. (1996) [Pubmed]
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